Therapeutic effects of three different oral contraceptive pills are comparable after 6 months of treatment. After 12 months, the cyproterone containing pill shows greater antiandrogenic effect. Effects on metabolic parameters are identical.
Hepatotoxicity is a rare but possible event when using low- and ultralow-dose regimens of flutamide for hyperandrogenic treatment. We need larger studies in order to identify risk patterns for hepatotoxicity development.
Anovulatory women with polycystic ovary syndrome (PCOS) and matched control subjects were followed for 5 years. Women with PCOS who had normal menses after 5 years had significantly lower initial serum antimullerian hormone levels.
This study evaluated the effect of tinzaparin and enoxaparin on extravillous trophoblast (EVTC) invasive properties. The observed beneficial effect of low molecular weight heparins (LMWHs) on EVTC invasiveness and on heparin binding-EGF and Cyr61 expression/secretion suggested a possible biological rationale for the clinical use of LMWHs in placental-mediated pregnancy complications.
Chlormadinone acetate down-regulated cyclo-oxygenase-2 messenger RNA expression and suppressed prostaglandin F2a production ex vivo in an interleukin-1b–stimulated human endometrial explants model, whereas the glucocorticoid reference compound dexamethasone showed no effect.
The levels of H3K4me3 and H3K27me3 show dynamic changes during human oocyte maturation and embryonic development. Asymmetric distribution of H3K27me3 exists in human zygote pronuclei, whereas H3K4me3 is always uniform.
Systematic analysis of 102 websites of IVF clinic and egg donor agency websites demonstrate considerable lack of compliance with ASRM's ethical guidelines regarding trait-based compensation, presentation of risks, and recruitment age minimums.
Women with reduced ovarian reserve or advanced maternal age have altered follicular cell metabolism, which is reflected in follicular fluid composition. This may represent a mechanism for reduced oocyte quality.
Hypothesizing that a combination of polymorphic variants of major endocrine constituents of the menstrual cycle determines ovarian reserve, only the ESR1-PvuII polymorphism was found to be a potential candidate for early prediction of premature ovarian aging in female infertility.
Endometrial cannabinoid receptor type 1 expression during the progesterone-dominant secretory phase is minimal in women with endometriosis, and exposure of endometrial cells to TCDD similarly disrupts cannabinoid signaling.
Endosalpingiosis appears to affect postmenopausal women at a rate much higher than previously reported. Endosalpingiosis and endometriosis occur concurrently in 34% of endosalpingiosis cases; however, the two diseases have different clinical presentations.
Prospective longitudinal evaluation of preconception stress biomarkers in relation to the secondary sex ratio demonstrated a significant association between preconception cortisol concentration and decreased odds of a male birth.
Type A personality (i.e., time urgency, job involvement, competitiveness) independently predicted hormone therapy use among 1,803 postmenopausal women of the French GAZEL Cohort Study, before and after the WHI publication.
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