October 2012

All the papers from the October 2012 issue of Fertility and Sterility.

Emerging nonanticoagulant role of low molecular weight heparins on extravillous trophoblast functions and on Heparin Binding Epidermal Growth Factor and Cystein Rich angiogenic inducer 61 expression

This study evaluated the effect of tinzaparin and enoxaparin on extravillous trophoblast (EVTC) invasive properties. The observed beneficial effect of low molecular weight heparins (LMWHs) on EVTC invasiveness and on heparin binding-EGF and Cyr61 expression/secretion suggested a possible biological rationale for the clinical use of LMWHs in placental-mediated pregnancy complications.

The CC allele of the PvuII polymorphic variant in intron 1 of the α estrogen receptor gene is significantly more prevalent among infertile women at risk of premature ovarian aging

Hypothesizing that a combination of polymorphic variants of major endocrine constituents of the menstrual cycle determines ovarian reserve, only the ESR1-PvuII polymorphism was found to be a potential candidate for early prediction of premature ovarian aging in female infertility.

What is Endosalpingiosis

Endosalpingiosis appears to affect postmenopausal women at a rate much higher than previously reported. Endosalpingiosis and endometriosis occur concurrently in 34% of endosalpingiosis cases; however, the two diseases have different clinical presentations.

Synchronization of Ovarian Stimulation with Follicle Wave Emergence in Patients undergoing in vitro fertilization with a Prior Suboptimal Response A Randomized Controlled Trial

Synchronizing ovarian stimulation with follicle wave emergence in patients with a prior suboptimal response resulted in an increase in the number of follicles that developed and serum E2 concentrations; however, corresponding improvements in oocyte, embryo, and pregnancy outcomes were not observed.