Pituitary Origin of Persistently Elevated Human Chorionic Gonadotropin in a Patient with Gonadal Failure

During sympathetic stimulation with a mental stress test, young patients with the classic PCOS phenotype showed lower heart rate variability response versus a healthy control group, after adjustment for age.

Only 48% of LH surges in ovulating women are single peaks of <5 days. The variants are associated with significant differences in follicle size and hormone levels.

The high plasma testosterone levels in swimmers did not have a detectable effect on bone mass acquisition. Among various factors, menstrual disorders may reduce the potentially favorable effect of androgens on bone.

The levels of follicular fluid and serum hepatocyte growth factor (HGF) and the expression of c-Met in polycystic ovary syndrome were determined along with the importance of HGF/c-Met signaling in fertilization success.

G-protein-coupled estrogen receptor-30 (GPR30) is highly expressed in uterine leiomyoma tissue and localized in the nuclei of leiomyoma cells; 17b-estradiol increases GPR30 expression in cultured leiomyoma smooth muscle cells.

Progestin-induced heart and neural crest derivatives expressed transcript 2 contributes to fibulin-1 expression in human endometrial stromal cells.

Vitrification of prepubertal mouse ovaries did not affect the methylation profile of Snrpn-DMR or their development and fertility potential.

Oxytocin receptor (OTR) levels in myometrial cells correlate with the severity of dysmenorrhea and uterine contractility in women with adenomyosis, and both trichostatin A and andrographolide dose-dependently inhibit OTR expression.

A live birth was obtained after frozen/thawed ovarian tissue autologous transplantation in a patient with precocious ovarian failure after chemotherapy and bone marrow transplantation.

Serum interleukin-19 and -22 are decreased in ovarian endometrioma. They may be involved in the pathogenesis of endometriosis.

Women with rectovaginal endometriosis were judged more physically attractive than women with peritoneal or ovarian endometriosis and than women with other benign gynecological conditions.

The high prevalence of maternal hypovitaminosis D in women who are pregnant during winter months in northern latitudes may have detrimental effects on fetal skeletal growth.

Cigarette smoking is not associated with quantitative differences in ciliation or ciliogenesis factor expression in human oviducts, suggesting other pathophysiologic mechanisms underlie the increased risk of ectopic pregnancy in women who smoke.

A scoring system aid in triage of women at risk for ectopic pregnancy validated in a racially, geographically diverse cohort, with comparable test characteristics for viable intrauterine and nonviable pregnancies.

The risk for antiphospholipid syndrome is the same after two, not necessarily consecutive, miscarriages, as for women with three or more miscarriages.

Aberrant expression of proinflammatory, anti-inflammatory, and angiogenic cytokines alters the endometrial milieu, affecting the endometrial development and receptivity during implantation window in women with idiopathic recurrent spontaneous miscarriage.

Endometrin monotherapy provided comparable pregnancy rates (PRs) in fresh autologous and fresh donor oocyte cycles. The addition of P in oil to Endometrin improved PRs in frozen transfer cycles.

Interval transfer of cryopreserved embryos derived from prior in vitro fertilization stimulation with elevated peak estradiol level reduces the risk of adverse obstetric outcomes.

The performance of twin pregnancies after fetal reduction procedure was tested in a prospective cohort study. Our work supports a lack of causative relationship between fetal reduction and pregnancy endpoint.

In vitro fertilization outcomes may be improved by performing frozen instead of fresh embryo transfer. These results could be explained by avoiding the deleterious effects of controlled ovarian hyperstimulation on endometrial receptivity.

No association was demonstrated between follicle-stimulating hormone receptor gene variants and ovarian response in women undergoing in vitro fertilization treatment, but clinically relevant differences cannot be ruled out.

The effects of clomiphene citrate on testicular function and steroidogenic enzyme gene expression were investigated in rats estrogenized with estradiol-3-benzoate.

Serum INSL3 correlates with intratesticular testosterone during hCG administration. Measurement of serum INSL3 may be a useful biomarker of intratesticular testosterone during hCG treatment of infertile men.

This clinical study demonstrates the significant association between HPV sperm infection and ASAs and their clearance time in infertile patients.

This study provides the first evidence that inflammasome proteins are present in human 24 semen, and suggests that the inflammatory innate immune response contributes to 25 abnormal semen quality in SCI men.

Examination of total levels and localisation patterns of PLCζ in control and patient sperm. Sperm from control and OAD males exhibited significant variance in total levels and localization patterns of PLCζ protein.

Perfringolysin O selectively permeabilizes the plasma membrane of human spermatozoa and can be used to assess changes in the amount and distribution of the active cholesterol fraction present in this membrane.

Normal semen analysis may not reflect important alterations in protein levels in the seminal plasma. A classic proteomics approach shows that unbalanced apoptosis may prevent normal spermatogenesis in the adolescent varicocele.

Defective protein kinase A and C pathways are commonly associated with disordered ZP–induced acrosome reaction in normozoospermic infertile men with normal sperm-ZP binding.

Oocytes expressing mutant sperm phospholipase Cz (PLCz) fail to activate, but microinjection of wild-type human PLCz rescues failed activation and triggers embryo development.

The CT genotype of GNB3 gene was more prevalent in patients with erectile dysfunction. The interaction between the T allele and erectile dysfunction was significant (P¼.004).

Reflections on “Elective cryopreservation of all embryos with subsequent cryothaw embryo transfer in patients at risk for ovarian hyperstimulation syndrome reduces the risk of adverse obstetric outcomes: a preliminary study” by Imudia et al.

Reflections on “Serum insulin-like factor 3 is highly correlated with intratesticular testosterone in normal men with acute, experimental gonadotropin deficiency stimulated with low-dose human chorionic gonadotropin: a randomized, controlled trial” by Roth et al.

Reflections on Zylbersztejn DS et al. “Proteomic analysis of seminal plasma in adolescents with and without varicocele”

This document contains the definitions for infertility and recurrent pregnancy loss as defined by the Practice Committee of the American Society for Reproductive Medicine.

This document provides the latest recommendations for evaluation of potential sperm, oocyte, and embryo donors.

Criteria for number of embryos to transfer A committee opinion

Evidence indicates that vitrification and warming of unfertilized oocytes followed by fertilization, commonly by intracytoplasmic sperm injection (ICSI), result in subsequent pregnancy rates which are acceptable and this technique should no longer be considered experimental.

A review of potential risks to offspring as well as the impact on fertility of advancing male age and a discussion of mechanisms by which male age may impact sperm.