A double-blind, randomized, placebo-controlled trial on the effects of metformin on serum levels of 8-hydroxy-20-deoxyguanosine (8-OHdG) in women with polycystic ovary syndrome showed levels were statistically significantly reduced versus placebo.
Young women with polycystic ovary syndrome and subclinical hypothyroidism present higher serum levels of low-density lipoprotein cholesterol with no changes in other lipid profile parameters, insulin resistance, or phenotypic manifestations.
In rats with cyclophosphamide-induced asthenozoospermia, CatSper1 and sperm motility were significantly reduced, whereas Sheng-Jing-San treatment restored the cyclophosphamide-induced down-regulation of CatSper1 and improved the sperm motility.
Nucleolar channel systems appear uniformly throughout the upper endometrial cavity, excluding the lower uterine segment, and preferentially in the functional luminal layers of the endometrium, indicating uniform secretory transformation.
In an established model of spontaneous adhesive disease associatedwith experimental human endometriosis in nude mice, development of adhesions was significantly reduced in animals provided with an antiinflammatory diet containing fish oil.
Microarray data revealed altered expression of several novel invasion-associated molecules in leukemia inhibitory factor (LIF)-treated HTR-8/SVneo cells, wherein silencing of pappalysin 1 reduced LIF-mediated invasion.
The study demonstrated that a specific survivin mRNA and protein are expressed in human oocytes and embryos. Embryos secrete survivin into culture media, and survivin concentrations are positively correlated with embryo cleavage rates.
In the same set of endometrial biopsies, the accuracy of the endometrial receptivity array diagnostic tool was superior to dating by endometrial histology, and was reproducible in the same patients 29–40 months later.
Sonographic lower uterine segment evaluation may be a good noninvasive, repeatable, safe technique for defining profile risk of uterine dehiscence or worse in women with previous cesarean section, especially more than 18 months later.
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