In utero exposures were not associated with a visualized endometriosis diagnosis in either an operative or population cohort of women in contrast to earlier evidence.

In the first experimental model of deep nodular endometriosis, lesions similar to endometriotic nodules were induced, and they invaded surrounding organs in more than 40% of cases.

In a Danish national register study on 523,757 women, an association between birth weight 4,500 g and an increased risk of PCOS in adult life was found in offspring of nondiabetic women.

African American women with fibroids have larger and more numerous fibroids compared with white women. Racial differences were not explained by a higher prevalence of known risk factors.

Children born to mothers who had more than two miscarriages, fertility problems, or prolonged time to pregnancy, had significantly higher risks of asthma during childhood. Maternal subfertility exposes offspring to an increased risk of asthma.

The kinase insert domain-containing receptor 604T/C polymorphism is associated with recurrent spontaneous abortion (RSA) in Korean women, whereas the 1719A/T polymorphism that is associated with RSA in Taiwanese Han women is not associated with RSA in Korean women.

This study identified a 12-gene signature in human cumulus cells predictive of pregnancy across multiple clinics. The positive predictive value of our test was 81% with an area under the receiver operating characteristic of 0.763  0.079.

With the use of time-lapse monitoring, to evaluate human embryo development, we describe a stage-dependent adverse response to atmospheric oxygen.

Neonatal and maternal outcomes were dramatically better for women undergoing two IVF singleton pregnancies compared with one IVF twin pregnancy.

Delayed administration of GnRH antagonist in a flexible protocol is associated with an attenuated pattern of ovarian response to stimulation but has no effect on implantation and pregnancy rates.

Testosterone therapy has a reversible suppression of spermatogenesis. Selective estrogen receptor modulators represent an alternative therapy for men who desire to maintain future potential fertility. Human chorionic gonadotropin therapy may be considered.

Density gradient and washing can remove HCV RNA or HIV RNA from microsurgical epididymal sperm aspiration or testicular sperm extraction samples obtained from HCV- or HIV-infected azoospermic men before ICSI.

Cationic surfactants show promise as womancontrolled spermicides. We show that, besides effects on vitality and motility, at lower concentrations they impair sperm function at various levels, not necessarily by acting as surfactants.

Asthenozoospermic spermatozoa exhibited a modification in plasma membrane rheology, and a reduced immunohistochemical expression of ezrin, Cdc42, CD9, F-actin, and b-tubulin, which could contribute to sperm functional impairment.

We discuss evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk.

Raman microspectroscopy scanning of single live sperm is able to distinguish the human zona pellucida–bound sperm from unbound sperm.

Reflections on “Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus” by Akhi et al.

Reflections on “Induction of endometriotic nodules in an experimental baboon model mimicking human deep nodular lesions” by Donnez et al.

Reflections on “The treatment of hypogonadism in men of reproductive age” by Kim et al.

This document describes the basics of sperm DNA integrity; assesses the evidence pertaining to the clinical utility of sperm DNA integrity testing; and targets areas that require more study.