March 2013

Polycystic ovary syndrome offspring display increased oxidative stress markers comparable to gestational diabetes offspring

The present study demonstrated that in PCOS neonates, the oxidative stress status was similar to that of GDM neonates and strongly associated with their mothers’ oxidative status.

Fertility and Sterility

Mar 01, 2013

March 2013

Psoriatic patients have an increased risk of polycystic ovary syndrome Results of a cross sectional analysis

This study is a cross-sectional analysis to determine the prevalence of PCOS in patients with psoriasis. The prevalence of PCOS in women with psoriasis is about 47%.

Fertility and Sterility

Mar 01, 2013

March 2013

A novel mouse model that closely mimics human uterine leiomyomas

Ex vivo expanded myoma cells or transformed and immortalized by SV40ER lose in vivo tumorigenicity. Injections of uncultured primary myoma cells produce stable xenografts with unique similarity to human fibroids.

Fertility and Sterility

Mar 01, 2013

March 2013

Inhibition of ghrelin signaling improves the reproductive phenotype of male ob/ob mouse

Ghrelin signaling is involved in the reproductive phenotype of ob/ob mouse.

Fertility and Sterility

Mar 01, 2013

March 2013

Immature myeloid cells derived from mouse placentas and malignant tumors demonstrate similar proangiogenic transcriptional signatures

Immature myeloid cells derived from placentas and tumors show similar molecular signatures. This common gene expression pattern may indicate that these cells share the same origins and functions.

Fertility and Sterility

Mar 01, 2013

March 2013

Modulation of microvascular permeability in the preovulatory rat ovary by an ovulatory gonadotropin stimulus

Preovulatory gonadotropin stimulation induces changes in ovarian permeability, with an increase in the radii of the small and large pores and a threefold increase in the large pore fraction of the hydraulic conductance.

Fertility and Sterility

Mar 01, 2013

March 2013

In vitro development and chromosome constitution of embryos derived from monopronucleated zygotes after intracytoplasmic sperm injection

All human embryos derived from monopronucleated zygotes after intracytoplasmic sperm injection are chromosomally abnormal and should be discarded for reproductive purposes.

Fertility and Sterility

Mar 01, 2013

March 2013

Letrozole increases ovarian growth and CYP17A1 gene expression

Letrozole increases ovarian size and androgen production and upregulates Cyp17a1 messenger RNA expression in the rat ovary.

Fertility and Sterility

Mar 01, 2013

March 2013

Dynamic alterations in the expression and localization of ACTL7a during capacitation in mouse spermatozoa

The expression of ACTL7a is up-regulated via the protein kinase A pathway and undergoes remodeling during the early period of capacitation in mouse spermatozoa.

Fertility and Sterility

Mar 01, 2013

March 2013

Targeting of syndecan-1 by micro-ribonucleic acid miR-10b modulates invasiveness of endometriotic cells via dysregulation of the proteolytic milieu and interleukin-6 secretion

Syndecan-1 inhibits invasiveness of epithelial endometriotic cells by modulating matrix metalloproteinases MMP-2 and MMP-9, plasminogen activator inhibitor-1, and interleukin-6 and is regulated by the microRNA miR-10b, both possible novel targets for therapeutic approaches.

Fertility and Sterility

Mar 01, 2013

March 2013

Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus

In a rat model of allogeneic uterus transplantation, the immunosuppressant tacrolimus effectively prevented uterine rejection, and expression patterns of inflammation-/implantation-related proteins of the uteri were similar to those of controls.

Fertility and Sterility

Mar 01, 2013

March 2013

MicroRNA expression in the human blastocyst

Human blastocysts express microRNAs, many of which are important for embryonic and stem cell development. Differential expression of microRNAs based on ploidy and sex were discovered.

Fertility and Sterility

Mar 01, 2013

March 2013

Mouse strain and quality control testing: improved sensitivity of the mouse embryo assay with embryos from outbred mice

Embryos from outbred mice are sensitive to in vitro toxins and may provide a more reliable measure of quality for undefined culture components such as mineral oil.

Fertility and Sterility

Mar 01, 2013

March 2013

The other side of the fertility coin: a comparison of childless men’s and women’s knowledge of fertility and assisted reproductive technology

An online questionnaire assessed fertility and ART knowledge of 599 childless men. These findings were compared to a sample of childless women. Significant knowledge gaps were identified.

Fertility and Sterility

Mar 01, 2013

March 2013

Do infertile women and their partners have equal experiences with fertility care?

In fertility care, we should listen to both members of the infertile couple. Our results show that experiences with patient-centered fertility care are only slightly different within the couple.

Fertility and Sterility

Mar 01, 2013

March 2013

Egg banking in the United States Current status of commercially available cryopreserved oocytes

Cryopreserved donor oocytes are widely available from commercial “egg banks” (CEBs); with over 3,000 oocytes currently in storage and 600 pregnancies already conceived. Most CEBs use the vitrification cryopreservation technique.

Fertility and Sterility

Mar 01, 2013

March 2013

CBX2 gene analysis in patients with 46 XY and 46 XX gonadal disorders of sex development

CBX2 gene disruption, described in one case of 46,XY ovarian disorder of sex development (DSD), is not a common cause of other gonadal DSD forms.

Fertility and Sterility

Mar 01, 2013

March 2013

PROKR2 mutations in autosomal recessive Kallmann syndrome

Report describes two brothers with two homozygous PROKR2 missense changes and Kallmann syndrome, and their healthy heterozygous carrier parents.

Fertility and Sterility

Mar 01, 2013

March 2013

Investigation of gene expression profiles before and after embryonic genome activation and assessment of functional pathways at the human metaphase II oocyte and blastocyst stage

Gene expression profiling at the human oocyte and blastocyst stage has identified similarities and differences in processes before and after embryonic genome activation.

Fertility and Sterility

Mar 01, 2013

March 2013

Parental attitudes toward fertility preservation in boys with cancer: context of different risk levels of infertility and success rates of fertility restoration

Parents of boys with cancer want some sort of fertility preservation, even if the risks of infertility or the success rates in restoring fertility were 20%.

Fertility and Sterility

Mar 01, 2013

March 2013

In utero exposures and endometriosis: the Endometriosis, Natural History, Disease, Outcome (ENDO) Study

In utero exposures were not associated with a visualized endometriosis diagnosis in either an operative or population cohort of women in contrast to earlier evidence.

Fertility and Sterility

Mar 01, 2013

March 2013

Induction of endometriotic nodules in an experimental baboon model mimicking human deep nodular lesions

In the first experimental model of deep nodular endometriosis, lesions similar to endometriotic nodules were induced, and they invaded surrounding organs in more than 40% of cases.

Fertility and Sterility

Mar 01, 2013

March 2013

Birth weight and polycystic ovary syndrome in adult life: a register-based study on 523,757 Danish women born 1973–1991

In a Danish national register study on 523,757 women, an association between birth weight 4,500 g and an increased risk of PCOS in adult life was found in offspring of nondiabetic women.

Fertility and Sterility

Mar 01, 2013

March 2013

Comparison of characteristics of fibroids in African American and white women undergoing premenopausal hysterectomy

African American women with fibroids have larger and more numerous fibroids compared with white women. Racial differences were not explained by a higher prevalence of known risk factors.

Fertility and Sterility

Mar 01, 2013

March 2013

Maternal fecundity and asthma among offspring—is the risk programmed preconceptionally? Retrospective observational study

Children born to mothers who had more than two miscarriages, fertility problems, or prolonged time to pregnancy, had significantly higher risks of asthma during childhood. Maternal subfertility exposes offspring to an increased risk of asthma.

Fertility and Sterility

Mar 01, 2013

March 2013

Association of kinase insert domain containing receptor KDR gene polymorphisms with idiopathic recurrent spontaneous abortion in Korean women

The kinase insert domain-containing receptor 604T/C polymorphism is associated with recurrent spontaneous abortion (RSA) in Korean women, whereas the 1719A/T polymorphism that is associated with RSA in Taiwanese Han women is not associated with RSA in Korean women.

Fertility and Sterility

Mar 01, 2013

March 2013

Identification of a novel gene set in human cumulus cells predictive of an oocyte's pregnancy potential

This study identified a 12-gene signature in human cumulus cells predictive of pregnancy across multiple clinics. The positive predictive value of our test was 81% with an area under the receiver operating characteristic of 0.763  0.079.

Fertility and Sterility

Mar 01, 2013

March 2013

Effect of oxygen concentration on human embryo development evaluated by time-lapse monitoring

With the use of time-lapse monitoring, to evaluate human embryo development, we describe a stage-dependent adverse response to atmospheric oxygen.

Fertility and Sterility

Mar 01, 2013

March 2013

Neonatal and maternal outcomes comparing women undergoing two in vitro fertilization (IVF) singleton pregnancies and women undergoing one IVF twin pregnancy

Neonatal and maternal outcomes were dramatically better for women undergoing two IVF singleton pregnancies compared with one IVF twin pregnancy.

Fertility and Sterility

Mar 01, 2013

March 2013

The effect of delayed initiation of gonadotropin-releasing hormone antagonist in a flexible protocol on in vitro fertilization outcome

Delayed administration of GnRH antagonist in a flexible protocol is associated with an attenuated pattern of ovarian response to stimulation but has no effect on implantation and pregnancy rates.

Fertility and Sterility

Mar 01, 2013

March 2013

The treatment of hypogonadism in men of reproductive age

Testosterone therapy has a reversible suppression of spermatogenesis. Selective estrogen receptor modulators represent an alternative therapy for men who desire to maintain future potential fertility. Human chorionic gonadotropin therapy may be considered.

Fertility and Sterility

Mar 01, 2013

March 2013

Intracytoplasmic sperm injection with microsurgically retrieved spermatozoa in azoospermic men infected with human immunodeficiency virus 1 or hepatitis C virus The EP43 AZONECO ANRS study

Density gradient and washing can remove HCV RNA or HIV RNA from microsurgical epididymal sperm aspiration or testicular sperm extraction samples obtained from HCV- or HIV-infected azoospermic men before ICSI.

Fertility and Sterility

Mar 01, 2013

March 2013

In vitro effects of cationic compounds on functional human sperm parameters

Cationic surfactants show promise as womancontrolled spermicides. We show that, besides effects on vitality and motility, at lower concentrations they impair sperm function at various levels, not necessarily by acting as surfactants.

Fertility and Sterility

Mar 01, 2013

March 2013

Involvement of sperm plasma membrane and cytoskeletal proteins in human male infertility

Asthenozoospermic spermatozoa exhibited a modification in plasma membrane rheology, and a reduced immunohistochemical expression of ezrin, Cdc42, CD9, F-actin, and b-tubulin, which could contribute to sperm functional impairment.

Fertility and Sterility

Mar 01, 2013

March 2013

Null genotypes of GSTM1 and GSTT1 contribute to male factor infertility risk a meta analysis

We discuss evidence that the null of GSTM1 and GSTM1-GSTM1 increased the risk of male factor infertility, but the null genotype of GSTT1 was not associated with an increased infertility risk.

Fertility and Sterility

Mar 01, 2013

March 2013

Real-time Raman microspectroscopy scanning of the single live sperm bound to human zona pellucida

Raman microspectroscopy scanning of single live sperm is able to distinguish the human zona pellucida–bound sperm from unbound sperm.

Fertility and Sterility

Mar 01, 2013

March 2013

Ensuring the future of uterine transplantation

Reflections on “Uterine rejection after allogeneic uterus transplantation in the rat is effectively suppressed by tacrolimus” by Akhi et al.

Fertility and Sterility

Mar 01, 2013

March 2013

Is there added value in inducing endometriosis in baboons by laparotomic peritoneal grafting of uterine tissue obtained after hysterotomy?

Reflections on “Induction of endometriotic nodules in an experimental baboon model mimicking human deep nodular lesions” by Donnez et al.

Fertility and Sterility

Mar 01, 2013

March 2013

The treatment of hypogonadism in men of reproductive age

Reflections on “The treatment of hypogonadism in men of reproductive age” by Kim et al.

Fertility and Sterility

Mar 01, 2013

March 2013

The clinical utility of sperm DNA integrity testing: a guideline

This document describes the basics of sperm DNA integrity; assesses the evidence pertaining to the clinical utility of sperm DNA integrity testing; and targets areas that require more study.

Fertility and Sterility

Mar 01, 2013