Reflections on “Evaluation of targeted next-generation sequencing-based preimplantation genetic diagnosis of monogenic disease” by Treff et al.
Proteomic analysis and sperm physiopathology: the two-dimensional difference in gel electrophoresis approach
Reflections on Hamada et al. “Two-Dimensional Differential In-Gel Electrophoresis-based proteomics of male gametes in relation to oxidative stress”
This Practice Committee opinion provides a revised definition of experimental procedures.
In vitro fertilization and risk of breast and gynecologic cancers: a retrospective cohort study within the Israeli Maccabi Healthcare Services
Among 87,403 infertile women, IVF was not significantly associated with breast or gynecologic cancers. Among women receiving four or more cycles, ovarian cancer was nonsignificantly elevated, supporting further risk monitoring.
In vitro maturation may be an attractive option in patients suffering from ovarian resistance to FSH and for preserving fertility in combination with ovarian tissue cryopreservation.
Pregnancies achieved after cryopreservation of in vitro and in vivo matured oocytes are not associated with adverse pregnancy outcomes and may represent a novel strategy of fertility preservation.
In vitro maturation, including FSH priming, recovery of oocytes from 12-mm follicles, and using single blastocyst transfer, is safe and provides pregnancy rates up to 40% in patients with PCO.
In normo-ovulatory women, in vitro maturation does not result in success rates similar to conventional ovarian stimulation regimens. However, it represents a milder approach to assisted reproduction treatment and an alternative intervention for specific conditions.
A discussion is presented concerning the health of IVM infants.