Of the 1,345 couples who consulted for male factor infertility, 407 patients discontinued treatment principally due to painfulness of treatment and its ineffectiveness. Of these patients, 20% finally succeeded in having a child.
Dropping out of couples from fertility treatment is well known. An observational retrospective cohort study was performed to evaluate whether prognostic profiles differed between couples who drop out and couples that continue IUI.
An incidental finding of a 46,XX SRY-negative phenotype was discovered during routine infertility investigations. We describe the case and propose clinical management guidance for the comprehensive management of this rare condition.
Spermatogonia-specific apoptosis does not explain the stem cell loss observed after intratesticular tissue grafting. Probably, hypoxia during the first days after transplantation induces degeneration of tubules in the center of the graft.
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.
Because DNA fragmentation, hyaluronan-binding ability, and induced hyperactivity of spermatozoa correlate with the fertilization rate after in vitro fertilization, blastocyst formation can be predicted by the sperm DNA fragmentation rate
For assessing sperm morphology, Testsimplets gives a statistically significantly lower number of normal forms, so its clinical application is not recommended over Diff-Quik, the quickest recommended technique.
Reflections on “Preimplantation genetic screening using fluorescence in situ hybridization in patients with repetitive implantation failure and advanced maternal age: two randomized trials” by Rubio et al.
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