Of the 1,345 couples who consulted for male factor infertility, 407 patients discontinued treatment principally due to painfulness of treatment and its ineffectiveness. Of these patients, 20% finally succeeded in having a child.
Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysi
The data of the present study clearly suggest that MTHFR A1298C polymorphism is a genetic risk factor for pregnancy loss, and it appears to be clinically important.
Antimüllerian hormone levels decrease in women using combined contraception independently of administration route
In young healthy, normal weight women, continuous use of combined contraception leads to a decrease in serum AMH levels independently of administration route.
Blastomere multinucleation has a negative impact on live birth.
Couples dropping out of a reimbursed intrauterine insemination program: what is their prognostic profile and why do they drop out?
Dropping out of couples from fertility treatment is well known. An observational retrospective cohort study was performed to evaluate whether prognostic profiles differed between couples who drop out and couples that continue IUI.
Intracytoplasmic morphologically selected sperm injection versus intracytoplasmic sperm injection: a step toward a clinical algorithm
Our group experience demonstrates a clinical advantage for IMSI procedure in patients who failed in their first ICSI or for patients who shifted between ICSI and IMSI modalities.
Trophectoderm grading, but not inner cell mass grading, significantly correlates with implantation and live birth for single-embryo transfers.
Consecutive gonadotropin-releasing hormone-antagonist in vitro fertilization cycles: does the elapsed time interval between successive treatments affect outcomes?
After IVF cycle failure, delaying consecutive IVF cycle start for two or more menstrual cycles is likely of no advantage compared with waiting only one endogenous menstrual cycle before proceeding.
A case report of an incidental finding of a 46,XX, SRY-negative male with masculine phenotype during standard fertility workup with review of the literature and proposed immediate and long-term management guidance
An incidental finding of a 46,XX SRY-negative phenotype was discovered during routine infertility investigations. We describe the case and propose clinical management guidance for the comprehensive management of this rare condition.
Spermatogonia-specific apoptosis does not explain the stem cell loss observed after intratesticular tissue grafting. Probably, hypoxia during the first days after transplantation induces degeneration of tubules in the center of the graft.
Obesity has an impact on semen quality, and adipokines appear to influence semen parameters potentially in conjunction with body mass index.
Altered microRNA expression profiles of human spermatozoa in patients with different spermatogenic impairments
Microarray and real-time polymerase chain reaction (PCR) studies reveal that microRNAs are differentially expressed in normal versus spermatogenically impaired males and have therapeutic potential for the development of biomarkers for male infertility.
The apoptotic pathway in fertile and subfertile men: a case-control and prospective study to examine the impact of merocyanine 540 bodies on ejaculated spermatozoa
The presence of merocyanine 540 staining bodies does not affect quantification of early and late apoptotic biomarkers in spermatozoa from fertile and subfertile men.
Are sperm DNA fragmentation, hyperactivation, and hyaluronan-binding ability predictive for fertilization and embryo development in in vitro fertilization and intracytoplasmic sperm injection?
Because DNA fragmentation, hyaluronan-binding ability, and induced hyperactivity of spermatozoa correlate with the fertilization rate after in vitro fertilization, blastocyst formation can be predicted by the sperm DNA fragmentation rate
For assessing sperm morphology, Testsimplets gives a statistically significantly lower number of normal forms, so its clinical application is not recommended over Diff-Quik, the quickest recommended technique.
Two-dimensional differential in-gel electrophoresis–based proteomics of male gametes in relation to oxidative stress
Proteomic analysis shows that differences in protein expression in spermatozoa producing higher levels of ROS may play a role in the pathophysiology of male infertility.
Sperm ROS formation and DNA damage as well as seminal plasma oxidative stress parameters were investigated in idiopathic infertile men. Intensive oxidative stress may have caused sperm dysfunction.
Reflections on “Standardization of laparoscopic pelvic examination” by Bedaiwy et al.
Interaction between oviductal epithelial cells and spermatozoa underlies a systems biology approach to treating infertility
Reflections on “Cell membrane proteins from oviductal epithelial cell line protect human spermatozoa from oxidative damage” by Chiu et al.