Falsely elevated serum antimüllerian hormone level in a context of heterophilic interference

A case of falsely elevated serum AMH level due to heterophilic interference in an infertile 37-year-old woman with rheumatoid arthritis is reported for the first time.

0
0
Like 0 Comment

Authors

Hélène Cappy, M.D., Pascal Pigny, Ph.D., Maryse Leroy-Billiard, M.D., Didier Dewailly, M.D., Sophie Catteau-Jonard, Ph.D.

Volume 99, Issue 6, Pages 1729-1732, May 2013

Abstract

Objective:

To describe a case of falsely elevated serum antimüllerian hormone (AMH) level in an infertile 37-year-old woman suffering from rheumatoid arthritis.

Design:

Case report.

Setting:

Lille University IVF center.

Patient:

A 37-year-old woman with rheumatoid arthritis demonstrating a high serum AMH level (74.5 ng/mL) and a low antral follicle count.

Intervention:

Assay with a Heterophilic Blocking Tube (HBT) to avoid heterophilic interference.

Main Outcome Measure(s):

Serum AMH level, ultrasound antral follicle count, hormonal assays on the 4th day of a spontaneous cycle.

Results:

The results of the infertility work-up were as follows: serum AMH: 74.5 ng/mL (15 fold the upper normal limit) (immunoassay: Immunotech®), LH: 3.2 IU/L, FSH: 4.5 IU/L, E2: 27 pg/mL, Prolactin: 10 ng/mL. The Antral Follicle Count (AFC: follicles from 2 to 9 mm) at ultrasound was 7 for both ovaries. As there were discrepancies between the serum AMH level and the results of the infertility work up using the bioassays, we suspected a case of falsely elevated AMH level due to heterophilic interference. A HBT® tube revealed a serum AMH level of 0.63 ng/mL.

Conclusion:

This case illustrates, for the first time, the possibility of falsely high serum AMH level due to heterophilic interference.

Read the full text at: http://www.fertstert.org/article/S0015-0282(12)02546-0/fulltext


Go to the profile of Fertility and Sterility

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.