May 2013

Variation in antimüllerian hormone concentration during the menstrual cycle may change the clinical classification of the ovarian response

Antimüllerian hormone varies according to the stage of the menstrual cycle, and the day of blood collection may alter the clinical classification of ovarian response in women seeking fertility therapy.

Fertility and Sterility

May 01, 2013

May 2013

Faster thrombin generation in women with polycystic ovary syndrome compared with healthy controls matched for age and body mass index

Young and overweight women with PCOS generated thrombin faster than paired controls matched for age and body mass index.

Fertility and Sterility

May 01, 2013

May 2013

Seasonal effects on vitamin D status influence outcomes of lifestyle intervention in overweight and obese women with polycystic ovary syndrome

Overweight and obese women with polycystic ovary syndrome who increased their serum 25-hydroxyvitamin D levels more during lifestyle intervention achieved greater improvement in waist circumference and cholesterol.

Fertility and Sterility

May 01, 2013

May 2013

Evaluating reported candidate gene associations with polycystic ovary syndrome

Variants associated with PCOS in the previously published literature failed to replicate in this case–control association study and meta-analysis.

Fertility and Sterility

May 01, 2013

May 2013

Tubo ovarian dysplasia in relationship with ovulation induction in rats

In a study on tubo-ovarian dysplasia, rats exposed to ovulation stimulation protocols exhibited tubal and ovarian histopathologic and immunohistochemical abnormalities with a dose effect different from those of genetic origin.

Fertility and Sterility

May 01, 2013

May 2013

Differential effects of CpG TLR9 axis on pregnancy outcome in nonobese diabetic mice and wild type controls

CpG-driven innate immune activation can cause activation and amplification of macrophages followed by their migration to the fetomaternal microenvironment, up-regulated tumor necrosis factor-a production, and consequent adverse outcomes of pregnancy.

Fertility and Sterility

May 01, 2013

May 2013

Human chorionic gonadotropin controls luteal vascular permeability via vascular endothelial growth factor by down-regulation of a cascade of adhesion proteins

Junctional proteins regulate vascular permeability in the human corpus luteum. We demonstrate that vascular endothelial cadherin, nectin 2, and claudin 5 are involved in this regulation in a mutually interacting manner.

Fertility and Sterility

May 01, 2013

May 2013

Lapatinib inhibits meiotic maturation of porcine oocyte-cumulus complexes cultured in vitro in gonadotropin-supplemented medium

Lapatinib, which is used in breast cancer treatment, inhibits resumption of meiosis in porcine oocyte-cumulus complexes.

Fertility and Sterility

May 01, 2013

May 2013

Egg Donor Informed Consent Tool (EDICT): development and validation of a new informed consent tool for oocyte donors

We describe the development of a new valid reliable tool (Egg Donor Informed Consent Tool [EDICT]) for assessing oocyte donors’ understanding of the process and risks associated with oocyte donation.

Fertility and Sterility

May 01, 2013

May 2013

Falsely elevated serum antimüllerian hormone level in a context of heterophilic interference

A case of falsely elevated serum AMH level due to heterophilic interference in an infertile 37-year-old woman with rheumatoid arthritis is reported for the first time.

Fertility and Sterility

May 01, 2013

May 2013

Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation

Women who carry a BRCA mutation experience menopause earlier, on average, than women who do not have a mutation, but the difference does not appear to affect fertility.

Fertility and Sterility

May 01, 2013

May 2013

The KAL1 pVal610Ile mutation is a recessive mutation causing Kallmann syndrome

A missense mutation of KAL1, c.1828G>A, led to pVal610Ile substitution in two brothers with Kallmann syndrome; their mother is heterozygous for this missense mutation encoded by the single-nucleotide polymorphism rs2229013.

Fertility and Sterility

May 01, 2013

May 2013

In vitro fertilization outcome in women with unoperated bilateral endometriomas

The presence of bilateral endometriomas at the time of IVF affects responsiveness to hyperstimulation but does not affect the quality of the oocytes retrieved and the chances of pregnancy.

Fertility and Sterility

May 01, 2013

May 2013

Possible involvement of signal transducer and activator of transcription-3 in cell–cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis

We demonstrate the significance of macrophages in the development of endometriosis and the involvement of signal transducer and activator of transcription-3 in interactions between endometrial stromal cells and macrophages.

Fertility and Sterility

May 01, 2013

May 2013

Postoperative digestive function after radical versus conservative surgical philosophy for deep endometriosis infiltrating the rectum

Women managed in accordance with a conservative surgical philosophy for rectal endometriosis seem to have better digestive outcomes when compared with those managed by the radical approach.

Fertility and Sterility

May 01, 2013

May 2013

Economic evaluation studies in reproductive medicine: a systematic review of methodologic quality

Although quality standards have been set for economic studies, there is considerable room for improvement in such studies in reproductive medicine.

Fertility and Sterility

May 01, 2013

May 2013

Intrauterine exposure to diesel exhaust diminishes adult ovarian reserve

Intrauterine exposure to acceptable levels of diesel exhaust diminishes ovarian reserve of sexually mature mice. The authors recommend more careful examination of the environmental guidelines in humans.

Fertility and Sterility

May 01, 2013

May 2013

Association of methionine synthase and thymidylate synthase genetic polymorphisms with idiopathic recurrent pregnancy loss

The MTR 2756AA and MTR 2756A–TS 6bp allele combination may contribute to prevalence of recurrent pregnancy loss (RPL) in Korean women.

Fertility and Sterility

May 01, 2013

May 2013

Methylation status of imprinted genes DLK1-GTL2, MEST (PEG1), ZAC (PLAGL1), and LINE-1 elements in spermatozoa of normozoospermic men, unlike H19 imprinting control regions, is not associated with idiopathic recurrent spontaneous miscarriages

Spermatozoa of normozoospermic men in idiopathic recurrrent spontaneous miscarriage do not reveal aberrations in DNA methylation at intergenic differentially methylated regions, MEST, ZAC, and LINE-1 CpG islands.

Fertility and Sterility

May 01, 2013

May 2013

Y chromosome azoospermia factor region microdeletions are not associated with idiopathic recurrent spontaneous abortion in a Slovenian population association study and literature review

Azoospermia factor region microdeletions were not detected in Slovenian men with IRSA. Our comparisons with previous studies show that Y chromosome microdeletions are most likely not associated with IRSA.

Fertility and Sterility

May 01, 2013

May 2013

The influence of female and male body mass index on live births after assisted reproductive technology treatment a nationwide register based cohort study

Both female and male body mass indices (BMI) is important for the outcome of in vitro fertilization/intracytoplasmic sperm injection treatments. Increased female and male BMIs negatively affect the chance of live birth, especially after IVF.

Fertility and Sterility

May 01, 2013

May 2013

Antimüllerian hormone in gonadotropin releasing-hormone antagonist cycles: prediction of ovarian response and cumulative treatment outcome in good-prognosis patients

AMH predicts oocyte yield and poor and excessive ovarian response in GnRH antagonist cycles and is associated with increased cumulative live-birth rates after single-blastocyst transfer in fresh and cryopreserved cycles.

Fertility and Sterility

May 01, 2013

May 2013

Perinatal outcomes in 375 children born after oocyte donation: a Danish national cohort study

Children born after oocyte donation have a higher risk of preterm birth and low birth weight than after standard in vitro fertilization, mainly due to the risk of preeclampsia.

Fertility and Sterility

May 01, 2013

May 2013

Number of supernumerary vitrified blastocysts is positively correlated with implantation and live birth in single-blastocyst embryo transfers

The number of supernumerary vitrified blastocysts correlates positively with the odds of implantation and live birth in single-blastocyst transfers.

Fertility and Sterility

May 01, 2013

May 2013

Outcome of cryotransfer of embryos developed from vitrified oocytes: double vitrification has no impact on delivery rates

The delivery rate after vitrification of embryos derived from vitrified oocytes is not impaired by double vitrification.

Fertility and Sterility

May 01, 2013

May 2013

Cost-effectiveness comparison between pituitary down-regulation with a gonadotropin-releasing hormone agonist short regimen on alternate days and an antagonist protocol for assisted fertilization treatments

Although the controlled ovarian stimulation protocol with short GnRH agonist in alternate days may lower the cost of an individual IVF cycle, it requires more cycles to achieve pregnancy.

Fertility and Sterility

May 01, 2013

May 2013

Serum human chorionic gonadotropin levels on the day before oocyte retrieval do not correlate with oocyte maturity

Serum hCG levels on the day before oocyte retrieval do not correlate with oocyte maturity.

Fertility and Sterility

May 01, 2013

May 2013

A randomized clinical trial to evaluate the effect of granulocyte-macrophage colony-stimulating factor (GM-CSF) in embryo culture medium for in vitro fertilization

In a prospective randomized study, addition of recombinant granulocyte-macrophage colony-stimulating factor to IVF embryo culture medium was found to increase ongoing implantation rate at gestational week 12 and live birth rate.

Fertility and Sterility

May 01, 2013

May 2013

Glycoprotein 130 promotes human blastocyst development in vitro

Supplementation of glycoprotein 130 to culture media increased blastocyst formation of human pre-embryos.

Fertility and Sterility

May 01, 2013

May 2013

Genetic evaluation procedures at sperm banks in the United States

The genetic evaluation processes at sperm donor facilities were evaluated. Results show variability in the genetic education content and methods of obtaining informed consent from donor applicants.

Fertility and Sterility

May 01, 2013

May 2013

Effect of an isotonic lubricant on sperm collection and sperm quality

Use of isotonic lubricant is safe during collection of semen samples.

Fertility and Sterility

May 01, 2013

May 2013

Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity

Abnormal head shape of fresh motile spermatozoa evaluated by elliptic Fourier analysis reflected sperm DNA fragmentation, providing a rationale for selecting spermatozoa by microscopic shape assessment in the IMSI procedure.

Fertility and Sterility

May 01, 2013

May 2013

Association of state and trait anxiety to semen quality of in vitro fertilization patients: a controlled study

The relationship between semen quality and psychological conditions relative to state and trait anxiety was investigated among 94 volunteer men enrolled in an in vitro fertilization (IVF) program.

Fertility and Sterility

May 01, 2013

May 2013

Antimüllerian hormone: is the writing on the wall for antral follicle count?

Reflections on “Antimüllerian hormone in GnRH antagonist cycles: Prediction of ovarian response and cumulative treatment outcome in good-prognosis patients” by Arce et al.

Fertility and Sterility

May 01, 2013

May 2013

Oocyte donation and the therapeutic misconception

Reflections on “Egg donor informed consent tool (EDICT): Development and validation of a novel informed consent tool for oocyte donors” by Skillern et al.

Fertility and Sterility

May 01, 2013

May 2013

BRCA mutations and fertility: do not push the envelope!

Reflections on “Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation” by Finch et al.

Fertility and Sterility

May 01, 2013

May 2013

Obesity and poor reproductive outcome: female and male body weight matter

Reflections on “The influence of female and male body mass index on live-births after Assisted Reproductive Technology treatment – a nationwide register-based cohort study” by Petersen et al.

Fertility and Sterility

May 01, 2013

May 2013

The essentiality of biological plausibility

Reflections on “Y chromosome azoospermia factor region microdeletions are not associated with idiopathic recurrent spontaneous abortion in Slovenian population: association study and literature review” by Pereza et al.

Fertility and Sterility

May 01, 2013

May 2013

Does morphologic analysis of sperm provide functional value?

Reflections on “Evaluation of sperm head shape at high magnification revealed correlation of sperm DNA fragmentation with aberrant head ellipticity and angularity” by Utsuno et al.

Fertility and Sterility

May 01, 2013

May 2013

Pathogenesis, consequences, and control of peritoneal adhesions in gynecologic surgery: a committee opinion

Postoperative adhesions are a natural consequence of tissue trauma and healing; however, adherence to microsurgical principles and minimally invasive surgery may help to reduce postoperative adhesions.

Fertility and Sterility

May 01, 2013