June 2013

The international agreement study on the diagnosis of the septate uterus at office hysteroscopy in infertile patients

The agreement on the hysteroscopic diagnosis of septate uterus was found to be poor. Clear definitions are needed to use hysteroscopy as a reliable screening tool for uterine cavity abnormalities.

Fertility and Sterility

Jun 01, 2013

June 2013

Fertility rate and subsequent pregnancy outcomes after conservative surgical techniques in postpartum haemorrhage 15 years of literature

In conservative surgical treatment of PPH, pelvic vessel embolization and compressive sutures are associated not only with high rates of subsequent fertility but also with placental disorders, intrauterine growth restriction, cesarean delivery, and PPH recurrence.

Fertility and Sterility

Jun 01, 2013

June 2013

Optimal waiting period for subsequent fertility treatment after various hysteroscopic surgeries

The duration of endometrial wound healing is different after various hysteroscopic surgeries. It can be clearly observed with postoperative monthly office hysteroscopic examinations.

Fertility and Sterility

Jun 01, 2013

June 2013

Neuroendocrine recovery initiated by cognitive behavioral therapy in women with functional hypothalamic amenorrhea a randomized controlled trial

Cognitive behavior therapy not only restored ovarian function in women with functional hypothalamic amenorrhea (FHA) but it also lowered cortisol levels and improved neuroendocrine and metabolic concomitants of FHA.

Fertility and Sterility

Jun 01, 2013

June 2013

Small glutamine rich tetratricopeptide repeat containing protein alpha is present in human ovaries but may not be differentially expressed in relation to polycystic ovary syndrome

Small glutamine-rich tetratricopeptide repeat–containing protein alpha is expressed in human ovarian tissues and has the potential to modulate androgen receptor signaling, but expression levels may not be abnormal in polycystic ovary syndrome.

Fertility and Sterility

Jun 01, 2013

June 2013

Peripubertal changes in circulating antimüllerian hormone levels in girls

Rate of ovarian primordial follicle recruitment increases prepubertally then declines again following the onset of puberty, while ovarian follicle activity continues to increase. These changes seem to track with the age of menarche.

Fertility and Sterility

Jun 01, 2013

June 2013

Involvement of the ganglion cholinergic receptors in gonadotropin-releasing hormone, catecholamines, and progesterone release in the rat ovary

Ganglionic cholinergic stimulation produces changes in ovarian release of progesterone, gonadotropin-releasing hormone, noradrenaline, and adrenaline; the ovarian nerve plexus regulates these mechanisms through the release of different neurotransmitters.

Fertility and Sterility

Jun 01, 2013

June 2013

Detection and quantification of maternal-effect gene transcripts in mouse second polar bodies: potential markers of embryo developmental competence

Differences in gene expression in individual second polar bodies may be potential markers for minimally invasive testing of embryo developmental competence.

Fertility and Sterility

Jun 01, 2013

June 2013

Granulocyte colony-stimulating factor with or without stem cell factor extends time to premature ovarian insufficiency in female mice treated with alkylating chemotherapy

Treatment of mice with G-CSF with or without SCF protects ovarian follicle pool and extends time to premature ovarian insufficiency in mice treated with alkylating chemotherapy.

Fertility and Sterility

Jun 01, 2013

June 2013

Levels and associations among self-esteem, fertility distress, coping, and reaction to potentially being a genetic carrier in women with diminished ovarian reserve

Among 62 women with diminished ovarian reserve, self-esteem significantly predicted fertility distress both directly and indirectly through emotional reactions to potentially being a fragile X premutation carrier.

Fertility and Sterility

Jun 01, 2013

June 2013

Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study

Data from a large U.S. case-control study of ovarian tumors revealed no significant association between fertility drug use and the risk of developing ovarian tumors among infertile women.

Fertility and Sterility

Jun 01, 2013

June 2013

Time costs of fertility care: the hidden hardship of building a family

A total of 319 couples seeking fertility treatment spent an average of 125 hours obtaining care. This burden significantly adds to the financial and mental stress of pursuing fertility treatment.

Fertility and Sterility

Jun 01, 2013

June 2013

Novel hormone treatment of benign metastasizing leiomyoma an analysis of five cases and literature review

Gonadotropin-releasing hormone agonist and/or an aromatase inhibitor treatment stabilized or improved disease in patients with benign metastasizing leiomyoma; a selective progesterone receptor modulator was associated with improved symptoms despite increasing fibroid size.

Fertility and Sterility

Jun 01, 2013

June 2013

Genetic polymorphisms of serotonin transporter and receptor 1A could influence success during embryo implantation and maintenance of pregnancy

Exploratory genetic analysis of functional polymorphisms 5-HTTLPR and rs6295 reveals clinical implications during early pregnancy loss events in recipients undergoing IVF treatments using donated oocytes.

Fertility and Sterility

Jun 01, 2013

June 2013

Five years' experience using oocyte vitrification to preserve fertility for medical and nonmedical indications

Vitrification of oocytes is a reproducible, safe, and efficient method for fertility preservation in both oncological and nononcological patients, with a rapidly increasing demand and proven efficacy.

Fertility and Sterility

Jun 01, 2013

June 2013

Transcriptional changes in the expression of chemokines related to natural killer and T-regulatory cells in patients with deep infiltrative endometriosis

Natural killer and T-regulatory cells participate in the pathogenesis of endometriosis; establishing the role of certain chemokines in modulating this response represents a fundamental key to understanding the inflammatory response.

Fertility and Sterility

Jun 01, 2013

June 2013

Mitochondrial displacement loop alterations are associated with endometriosis

Mitochondrial displacement (D-) loop alterations may constitute an inheritable risk factor for endometriosis. The analysis of D-loop alterations might help to identify patients at high risk for disease outcome.

Fertility and Sterility

Jun 01, 2013

June 2013

The oncofetal protein IMP3: a novel biomarker and triage tool for premalignant atypical endometriotic lesions

Immunohistochemical staining for IMP3 is a simple, inexpensive, and sensitive test that can be used as a triage tool to discriminate between preneoplastic atypia and confounding benign conditions.

Fertility and Sterility

Jun 01, 2013

June 2013

Augmented epithelial multidrug resistance–associated protein 4 expression in peritoneal endometriosis: regulation by lipoxin A4

Multidrug resistance–associated protein 4 expression is augmented in peritoneal endometriotic lesions, where it localizes to glandular epithelial cells and is inhibited by lipoxin A4 in endometriotic epithelial cells in vitro.

Fertility and Sterility

Jun 01, 2013

June 2013

Volitional determinants and age-related decline in fecundability: a general population prospective cohort study in Denmark

Fecundability peaks around age 30 years and then declines, more steeply for nulliparous women. Men have a more modest decline with age. Volitional factors can offset some of the decline.

Fertility and Sterility

Jun 01, 2013

June 2013

Racial differences in fibroid prevalence and ultrasound findings in asymptomatic young women (18–30 years old): a pilot study

Racial differences in fibroid prevalence exist even in young asymptomatic women. Findings of thicker endometrium in black women warrant further investigation, given possible clinical implications.

Fertility and Sterility

Jun 01, 2013

June 2013

Comparison of embryo morphokinetics after in vitro fertilization-intracytoplasmic sperm injection in smoking and nonsmoking women

The comparison of embryo morphokinetics after IVF-ICSI cycles according to female smoking status showed that early embryo development is impaired by female smoking, leading to poor IVF outcome.

Fertility and Sterility

Jun 01, 2013

June 2013

Elective single embryo transfer trends and predictors of a good perinatal outcome—United States, 1999 to 2010

Elective single ET in the United States increased from 1999–2010. One-third of elective single ET among 35–37-year-olds resulted in a good perinatal outcome; transfer guidelines could be expanded.

Fertility and Sterility

Jun 01, 2013

June 2013

A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage

CGB5 promoter variants were associated with a modest but significant effect on reducing recurrent miscarriage (RM) risk. No common genetic variants in CGB5 and CGB8 were associated with increased RM susceptibility.

Fertility and Sterility

Jun 01, 2013

June 2013

Genetic variation in tissue inhibitors of metalloproteinases as a risk factor for idiopathic recurrent spontaneous abortion

There were no statistically significant differences in the distribution of genotype and allele frequencies of tissue inhibitors of metalloproteinases 1, 2, 3, and 4 gene polymorphisms between idiopathic recurrent spontaneous abortion couples and control subjects.

Fertility and Sterility

Jun 01, 2013

June 2013

Effect of prior birth and miscarriage frequency on the prevalence of acquired and congenital uterine anomalies in women with recurrent miscarriage: a cross-sectional study

Diagnostic imaging for congenital and acquired uterine anomalies should be recommended to women after two recurrent miscarriages, even if they have had a prior live birth.

Fertility and Sterility

Jun 01, 2013

June 2013

Three-dimensional power Doppler study of endometrial and subendometrial microvascularization in women with intrauterine device–induced menorrhagia

Endometrial and subendometrial microvascularization was increased in women with IUD-induced menorrhagia, as evidenced by 3D power Doppler analysis; however, this finding has no predictive value before IUD insertion.

Fertility and Sterility

Jun 01, 2013

June 2013

Personalized prediction of first-cycle in vitro fertilization success

Personalized first-cycle IVF live birth predictions can better identify patients with good-to-excellent prognoses.

Fertility and Sterility

Jun 01, 2013

June 2013

Phenotypic differences in children conceived from fresh and thawed embryos in in vitro fertilization compared with naturally conceived children

Whether a fresh or thawed IVF embryo is transferred affects the height and growth factor and lipid profiles in childhood, so embryo derivation should be considered when assessing childhood outcomes.

Fertility and Sterility

Jun 01, 2013

June 2013

Prospective controlled study to evaluate laboratory and clinical outcomes of oocyte vitrification obtained in in vitro fertilization patients aged 30 to 39 years

In a sibling oocyte study conducted in infertile patients 30–39 years of age, oocyte vitrification had minimal negative impact on embryo development and subsequent clinical results.

Fertility and Sterility

Jun 01, 2013

June 2013

Estrogen-suppressed in vitro maturation: a novel approach to in vitro maturation

Estrogen-suppressed in vitro maturation eliminates the need for gonadotropin stimulation and cycle monitoring yet results in a 40% live-birth rate.

Fertility and Sterility

Jun 01, 2013

June 2013

Vasectomy demographics and postvasectomy desire for future children: results from a contemporary national survey

Various demographic factors were identified to influence vasectomy prevalence (6.6%), and 19.6% of vasectomized men desired future children, revealing a need for additional counseling on permanent contraceptive methods.

Fertility and Sterility

Jun 01, 2013

June 2013

Determinants of testosterone recovery after bariatric surgery: is it only a matter of reduction of body mass index?

Body mass index correlation with sex hormones is exponential for testosterone and power for sex hormone–binding globulin (SHBG). Bariatric surgery improves all parameters with a higher than expected (for corresponding weight loss) increase of total testosterone and SHBG.

Fertility and Sterility

Jun 01, 2013

June 2013

Intracytoplasmic sperm injection outcome of ejaculated versus extracted testicular spermatozoa in cryptozoospermic men

Testicular sperm extraction is justified in patients with cryptozoospermia who fail to conceive by ICSI using ejaculated spermatozoa, as it offers a higher pregnancy rate.

Fertility and Sterility

Jun 01, 2013

June 2013

Sperm DNA fragmentation in men with malignancy

This observational study of sperm DNA fragmentation in men with malignancy presenting for semen cryopreservation compared with men presenting for sperm donation found no difference in sperm DNA fragmentation indices.

Fertility and Sterility

Jun 01, 2013

June 2013

A novel in vitro sperm head decondensation protocol for rapid flow cytometric measurement of deoxyribonucleic acid content

This study establishes a simple method for in vitro sperm head decondensation, which allows an accurate detection of real sperm DNA content and direct quantification of diploid sperm.

Fertility and Sterility

Jun 01, 2013

June 2013

Interindividual concurrence in interpretation of findings of hysteroscopic videos

Reflections on “The international agreement study on the diagnosis of the septate uterus at office hysteroscopy in infertile patients” by Smit et al.

Fertility and Sterility

Jun 01, 2013

June 2013

Epithelial ovarian tumors and fertility drugs—are we asking the right questions?

Reflections on “Fertility drug use and the risk of ovarian tumors in infertile women: a case-control study” by Asante et al.

Fertility and Sterility

Jun 01, 2013

June 2013

The two health disparities of uterine fibroids

Reflections on “Racial differences in fibroid prevalence and ultrasound findings in asymptomatic young women (18-30 years old): A pilot study” by Marsh et al.

Fertility and Sterility

Jun 01, 2013

June 2013

Use of antimüllerian hormone: the risks of interpreting ovarian reserve markers in isolation

Reflections on “Why we may abandon basal follicle-stimulating hormone testing: A sea change in determining ovarian reserve using antimüllerian hormone” by Toner et al.

Fertility and Sterility

Jun 01, 2013