Clinical application of uterus transplantation requires a full discussion of the medical, ethical, and social problems before its use in patients.
All the papers from the July 2013 issue of Fertility and Sterility.
Identification of a novel sperm motility–stimulating protein from caprine serum: its characterization and functional significance
A sperm forward motility–stimulating protein was purified from goat serum and characterized. The research provides a potential nonsteroidal biomolecule and its antibody that may solve some global reproductive problems.
Natural male aging negatively affects both in vivo and in vitro reproductive outcomes in an outbred murine model.
Effect of vitrification on promoter CpG island methylation patterns and expression levels of DNA methyltransferase 1o, histone acetyltransferase 1, and deacetylase 1 in metaphase II mouse oocytes
Vitrification does not significantly affect the methylation patterns of the CpG islands in the Dnmt1o, Hat1, and Hdac1 promoters in mouse metaphase II oocytes, but reduces expression of Dnmt1o mRNA.
Resistin decreases insulin-like growth factor I–induced steroid production and insulin-like growth factor I receptor signaling in human granulosa cells
Human ovarian follicles express resistin, which decreases insulin-like growth factor I (IGF-I)-induced steroid production, P450scc and P450 aromatase protein levels, and IGF-I receptor signaling pathways in primary human granulosa cells.
Mitochondria are significantly activated in growthrestricted fetuses, which may be a response to adverse intrauterine environments rather than to genetic factors.
Estrogen receptor β agonist diarylpropionitrile inhibits lipopolysaccharide-induced regulated on activation normal T cell expressed and secreted (RANTES) production in macrophages by repressing nuclear factor κB activation
Inhibition of lipopolysaccharide-induced RANTES production by estrogen receptor b agonist diarylpropionitrile in the macrophage cell line RAW264.7 may be mediated via repression of nuclear factor kB activation.
Role of angiotensin II and angiotensin-(1–7) in diabetes-induced oxidative DNA damage in the corpus cavernosum
Diabetes induces oxidative DNA damage in the corpus cavernosum. Angiotensin-(1–7), a counter-regulator of angiotensin II signaling, significantly attenuates DNA damage and structural changes in the corpus cavernosum.
In subfertile women with anovulation we evaluated the prevalence of additional fertility-reducing factors and the diagnostic and prognostic capacity of fertility tests.
Phenotypic comparison of Caucasian and Asian women with polycystic ovary syndrome: a cross-sectional study
Caucasian and Asian women with polycystic ovary syndrome living in the same geographic region have a similar prevalence of hirsutism and other markers for androgen excess.
Is the fertile window extended in women with polycystic ovary syndrome? Utilizing the Society for Assisted Reproductive Technology registry to assess the impact of reproductive aging on live-birth rate
Below the age of 40, women with polycystic ovary syndrome have higher clinical pregnancy and live-birth rates after in vitro fertilization compared with women with tubal factor infertility. After 40, despite a higher oocyte yield, there is no difference in pregnancy outcomes.
Functional neuroimaging of emotional processing in women with polycystic ovary syndrome: a case-control pilot study
Functional magnetic resonance imaging of limbic activation with emotional processing differed between healthy women and women with insulinresistant polycystic ovary syndrome.
Influences on endometrial development during intrauterine insemination: clinical experience of 2,929 patients with unexplained infertility
There is increasing awareness of the importance of endometrial development in infertile patients. In a large unexplained infertility population, we describe the factors affecting adverse endometrial development during IUI cycles.
Several factors, such as genetic, epigenetic, steroids, growth factors, cytokines, chemokines, and extracellular matrix components, have been identified in myometrial and leiomyoma biology that are hereby reviewed and discussed.
Preservation of human ovarian follicles within tissue frozen by vitrification in a xeno-free closed system using only ethylene glycol as a permeating cryoprotectant
Clinical-grade vitrification of human ovarian tissue in fertility preservation, with the use of only one permeating cryoprotectant, ethylene glycol, in a closed system results in intact follicular ultrastructure.
Bisphenol A and phthalates and endometriosis: the Endometriosis: Natural History, Diagnosis and Outcomes Study
Several phthalates but not bisphenol A were associated with incident endometriosis in the population cohort, whereas two phthalates emerged in sensitivity analyses for the operative cohort
In this systematic meta-analysis of both cohort and case-control studies, published through September 2012, we found an increased risk for cancer among children born after fertility treatment.
Effect of maternal chronic disease on obstetric complications in twin pregnancies in a United States cohort
Among twin pregnancies, maternal chronic disease was associated with additional risk of earlier delivery and cesarean section after spontaneous labor, but not with other obstetric complications.
Leptin and its receptor (ObR) are induced in ovarian endometriomas. There was positive correlation between ObR and adiponectin expression. The leptin-ObR system was associated with adiponectin gene expression in endometriotic cells.
Altered circulating levels of matrix metalloproteinases 2 and 9 and their inhibitors and effect of progesterone supplementation in women with endometriosis undergoing in vitro fertilization
Overexpression of matrix metalloproteinases (MMPs) 2 and 9 and decrease in tissue inhibitor of MMP (TIMP) 1 were associated with poor IVF outcome in women with endometriosis. Progesterone supplementation following IVF improved the MMP-9/TIMP-1 imbalance significantly in these women.