All the papers from the August 2013 issue of Fertility and Sterility.
Optimal in vitro fertilization in 2020 should reduce treatment burden and enhance care delivery for patients and staff
Optimal IVF for 2020 should include a way of reducing treatment burden and enhancing care delivery for patients and staff and empower people to optimize their chances of achieving parenthood.
In the human assisted reproduction laboratory, should equipment, utensils, and consumables, as well as culture and embryo selection strategies, be systematically evaluated before being introduced into routine u
This review summarizes key economic considerations of assisted reproductive technology (ART) treatment from a global perspective, highlighting how significant differences in costs and funding arrangements globally influence access to treatment and clinical practice.
Costa Rica's absolute ban on in vitro fertilization deemed a human rights violation: implications for U.S. assisted reproductive technology policy and “personhood” initiatives
IVF was illegal in Costa Rica until overturned by the Inter-American Court of Human Rights. This provides support for those opposed to current efforts in the U.S. to declare personhood upon fertilization or conception.]
This opinion of the ASRM Ethics Committee analyzes the ethical issues raised by assisted reproduction program fee structures in which patients pay more initially but receive a partial refund if treatment fails.
This document discusses the ethical issues surrounding donation of embryos or oocytes to women of advanced age.
This document reviews the mechanism of clomiphene citrate action, use in women with anovulatory and unexplained infertility, administration, side effects, and alternatives.
Reflections on “Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers” by Herwig et al.
Reflections on “Efficacy of intrauterine inseminations as a training modality for performing embryo transfer in reproductive endocrinology and infertility fellowship programs” by Shah et al.
Proteomic analysis of seminal plasma from infertile patients with oligoasthenoteratozoospermia due to oxidative stress and comparison with fertile volunteers
The largest proteomic data set to date of seminal plasma from idiopathic oligoasthenoteratozoospermia (iOAT) and fertile subjects is presented, with 46 proteins implicated in oxidative stress and immune response in iOAT.
One out of five patients with prostate cancer considered preoperative sperm banking to be very important, and most wanted a dedicated service for preoperative sperm cryopreservation.
Effects of combined antioxidant supplementation on human sperm motility and morphology during sperm manipulation in vitro
Combined treatment with taurine, cysteine, and glutathione improves the quality of human sperm by decreasing the rate of reduction in sperm motility during in vitro manipulation.
Sperm vacuoles negatively affect outcomes in intracytoplasmic morphologically selected sperm injection in terms of pregnancy, implantation, and live-birth rates
The presence of sperm vacuoles does not affect fertilization rate and embryo quality but significantly influences pregnancy, implantation, and live-birth rates.
Efficacy of intrauterine inseminations as a training modality for performing embryo transfer in reproductive endocrinology and infertility fellowship programs
Pregnancy rates for the first 100 ETs performed by reproductive endocrinology and infertility fellows were unchanged after an IUI training requirement. The substantial variation noted among fellows decreased as more ETs were completed.
Utilization and success rates of unstimulated in vitro fertilization in the United States: an analysis of the Society for Assisted Reproductive Technology database
This is the first report, based on the SART database, of utilization and outcomes of unstimulated (natural cycle) IVF in the United States. Natural cycle IVF should be considered as a therapy for infertile couples.
Comparative analysis of fetal and neonatal outcomes of pregnancies from fresh and cryopreserved/thawed oocytes in the same group of patients
This is an analysis of fetal and neonatal outcomes from fresh and thawed oocyte cycles in the same group of 855 patients.
Reduced oxygen tension improves embryo quality but not clinical pregnancy rates: a randomized clinical study into ovum donation cycles
The use of reduced oxygen tension during in vitro culture improves embryo quality but does not affect ongoing pregnancy rates in ovum donation cycles.
A case of pelvic actinomycosis complicated by bilateral tuboovarian abscesses after assisted reproduction was treated with intravenous antibiotics and computed tomography-guided drainage of the pelvic abscesses, resulting in full recovery.
Improving embryo selection using a computer-automated time-lapse image analysis test plus day 3 morphology: results from a prospective multicenter trial
Noninvasive computer-automated measurement of cell cycle times, in combination with standard morphological evaluation, significantly improves day 3 embryo selection compared with standard morphological evaluation alone.
Prediction of an excessive response in in vitro fertilization from patient characteristics and ovarian reserve tests and comparison in subgroups: an individual patient data meta-analysis
This IPD meta-analysis demonstrates that AFC and AMH add value to age in predicting excessive response to ovarian hyperstimulation and that the accuracy of some ovarian reserve tests is affected by age.
Predictors of ovarian response in women treated with corifollitropin alfa for in vitro fertilization/intracytoplasmic sperm injection
We discuss how antimullerian hormone level and antral follicle count are the best predictors for low and excessive responses in women treated with corifollitropin alfa in an antagonist protocol.
Use of a combined oral contraceptive or progestin-only contraceptives did not affect the amount of infant milk intake and growth from 6 to 9 weeks of age.
Trends and determinants of use of long-acting reversible contraception use among young women in France: results from three national surveys conducted between 2000 and 2010
Long-acting reversible contraceptive use remains low among young women with little progress in the last decade, pointing to the failure of family planning policies in altering contraceptive norms in Franc
Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy
Nasal epithelial adrenomedullin expression is decreased in tubal ectopic pregnancy, which is associated with reduced ciliary beat frequency, and this may help predict the risk of tubal ectopic pregnancy.
Ovarian damage after laparoscopic endometrioma excision is more severe in ovaries from which an endometrioma 4 cm in diameter has been excised.
Obesity was associated with PCOS in adolescents. Studies based on diagnosis codes only may underestimate the prevalence of PCOS and overestimate the magnitude of the association between obesity and PCOS.
Inverse associations were observed between serum bisphenol-A (BPA) concentration and androstenedione, free testosterone, and free androgen index and a positive association between serum BPA concentration and sex hormone-binding globulin.
The impact of culture conditions on early follicle recruitment and growth from human ovarian cortex biopsies in vitro
The use of a dynamic fluidic culture system for standardized ovarian cortex biopsies enables both follicle survival and initiation of the earliest follicle development to be better achieved.
Age-specific probability of live birth with oocyte cryopreservation: an individual patient data meta-analysis
Age-specific probabilities of live birth calculated in this report would enable more accurate counseling and informed decisions for infertile women considering oocyte cryopreservation.
Menopause was independently associated with the presence of leukoaraiosis after adjusting for age and vascular risk factors.
Comparative serum proteomic analysis of adenomyosis using the isobaric tags for relative and absolute quantitation technique
We identified 25 serum proteins (4 down-regulated, 21 up-regulated) that were differentially expressed between adenomyosis patients and healthy women using iTRAQ labeling technology; 3 of these proteins were also analyzed using Western blotting.
Coital frequency and infertility: which male factors predict less frequent coitus among infertile couples?
The coital frequency of infertile couples was studied. Median monthly coitus was 7 and the lowest quartile was <5. Older age and erectile dysfunction were independent predictors of less frequent coitus in this population. Authors
One-year follow-up of serum antimüllerian hormone levels in patients with cystectomy: are different sequential changes due to different mechanisms causing damage to the ovarian reserve?
After cystectomy for endometriomas, the decreased serum antimullerian hormone level can recover; removal of the ovarian cortex may be involved in the ovarian reserve decrease just after surgery.
Conceiving of change: a brief intervention increases young adults' knowledge of fertility and the effectiveness of in vitro fertilization
After an educational intervention, university students in Australia had significantly increased knowledge of fertility and IVF effectiveness and significantly decreased desired ages at commencement and completion of childbearing.
Effect of mood states and infertility stress on patients' attitudes toward embryo transfer and multiple pregnancy
Changes in mood during IVF treatment are associated with changes in perceived risk and in attitudes toward multiple pregnancy, but they do not necessarily result in a shift in transfer preferences.
Transforming growth factor β1 and its receptor soluble endoglin are altered in polycystic ovary syndrome during controlled ovarian stimulation
Increased transforming growth factor-b1 and decreased levels of its receptor, soluble endoglin are found in women with polycystic ovarian syndrome (PCOS) and may be implicated in PCOS pathogenesis and its increased risk for ovarian hyperstimulation.
Variability in protein quality used for embryo culture: embryotoxicity of the stabilizer octanoic acid
Octanoic acid, a stabilizer in albumin preparations, inhibits embryo development; because concentrations of octanoic acid vary among lots, it is a defined embryo toxin for routine screening.