Cleavage-stage biopsy significantly impairs human embryonic implantation potential while blastocyst biopsy does not: a randomized and paired clinical trial
A paired randomized trial demonstrated a 39% relative reduction in implantation rates of embryos after cleavage-stage biopsy. In contrast, blastocyst biopsy had no adverse effect.
Is neonatal uterine bleeding involved in the pathogenesis of endometriosis as a source of stem cells?
Endometrial bleeding in the neonate, an event totally neglected by modern investigators, may play a role in the pathogenesis of at least early onset endometriosis and represent a potential source of endometrial stem cells. The bleeding is a well-established phenomenon occurring at the end of the first week, but is more often occult than visible. The structure and functional obstruction of the endocervical canal in the fetus at term suggest increased likelihood of retrograde flow of the endometrial shedding.
Pregnancies and deliveries per fresh cycle are no longer adequate indicators of in vitro fertilization program quality: how should registries adapt?
The author of this Conceptions article suggests changes in the structure of clinic-specific reporting.
Comprehensive chromosome screening of trophectoderm with vitrification facilitates elective single-embryo transfer for infertile women with advanced maternal age
Comprehensive chromosome screening of trophectoderm with vitrification and later transfer in an unstimulated cycle may be the key to providing elective single-embryo transfer for the older woman undergoing IVF.
Contemporary biopsy for preimplantation genetic testing is most safely and effectively accomplished via trophectoderm biopsy at the blastocyst stage.
The different technologies available for 24-chromosome copy number analysis at the single-cell level for preimplantation genetic screening are compared.
Aneuploidy screening of all chromosomes (preimplantation genetic screening) at each stage of embryo development, the techniques available, and the advantages and disadvantages of each technique are reviewed.