A high proportion of dead spermatozoa in raw semen samples increases the generation of endogenous reactive oxygen species and nuclear DNA fragmentation when frozen-thawed, impairing IVF ability and embryo development.
In mock donor-egg assisted reproduction technology cycles, daily subcutaneous administration of 25 mg or 50 mg progesterone reproduces the physiologic secretory transformation of the endometrium seen in the luteal phase.
KAL1 mutations are associated with a more severe phenotype. KAL1 exon deletions are especially frequent and more accurately detected by MLPA, as spurious pseudogene amplification can occur in absence of KAL1.
Children born after assisted reproduction show no consistent deficits in any specific neurodevelopmental outcomes, at any age. The neurodevelopment is overall comparable to that of children born after spontaneous conception.
Through a content analysis of nine existing posthumous sperm procurement (PSP) policies, we identified the major components important to a thorough protocol and developed two competing models for PSP policies.
There is no evidence of abnormal endometrial integrin expression in women with recurrent implantation failure. The expression of integrins a1, a4, and aVb3 have no prognostic value in subsequent IVF treatment.
The endometrial receptivity array identifies the personalized window of implantation in patients with repeated implantation failure of endometrial origin and guides personalized embryo transfer as a treatment.
Genomewide gene expression profiling of cells recovered by uterine aspiration can identify robust candidate endometrial receptivity biomarkers while not disrupting implantation, enabling future validation by direct association with clinical outcome.
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of gestational diabetes mellitus, particularly in heavier women.
Reduced levels of hemopexin in the peritoneal fluid of patients with endometriosis compared with controls might indicate altered heme and iron metabolism in the peritoneal fluid of patients with endometriosis.
Ectopic endometrial stromal cells from patients with endometriosis have similar immunophenotype but exhibit altered proliferation, invasion, adhesion, and cytokine production compared with their eutopic counterparts, suggesting the involvement of epigenome in their behavior.
A prospective, multicenter study to assess the learning curve of hysteroscopic sterilization in 15 gynecologists in the Netherlands showed a statistically significant decrease of procedure time with increasing experience.
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