Endometrial hormone receptor expression was altered during ovarian stimulation cycles and was independent from serum E2 levels.
All the papers from the September 2013 issue of Fertility and Sterility.
Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols
Vitrification protocols containing 1,2-propanediol induced significant DNA damage on mouse oocytes before cooling and after warming.
Dead spermatozoa in raw semen samples impair in vitro fertilization outcomes of frozen-thawed spermatozoa
A high proportion of dead spermatozoa in raw semen samples increases the generation of endogenous reactive oxygen species and nuclear DNA fragmentation when frozen-thawed, impairing IVF ability and embryo development.
A randomized trial comparing the endometrial effects of daily subcutaneous administration of 25 mg and 50 mg progesterone in aqueous preparation
In mock donor-egg assisted reproduction technology cycles, daily subcutaneous administration of 25 mg or 50 mg progesterone reproduces the physiologic secretory transformation of the endometrium seen in the luteal phase.
Combined use of multiplex ligation-dependent probe amplification and automatic sequencing for identification of KAL1 defects in patients with Kallmann syndrome
KAL1 mutations are associated with a more severe phenotype. KAL1 exon deletions are especially frequent and more accurately detected by MLPA, as spurious pseudogene amplification can occur in absence of KAL1.
Children born after assisted reproduction show no consistent deficits in any specific neurodevelopmental outcomes, at any age. The neurodevelopment is overall comparable to that of children born after spontaneous conception.
A content analysis of posthumous sperm procurement protocols with considerations for developing an institutional policy
Through a content analysis of nine existing posthumous sperm procurement (PSP) policies, we identified the major components important to a thorough protocol and developed two competing models for PSP policies.
Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study
In a prospective cohort study in subfertile women with elevated basal FSH levels, AMH is identified as a marker for actual fertility.
Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome
There is no evidence of abnormal endometrial integrin expression in women with recurrent implantation failure. The expression of integrins a1, a4, and aVb3 have no prognostic value in subsequent IVF treatment.
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure
The endometrial receptivity array identifies the personalized window of implantation in patients with repeated implantation failure of endometrial origin and guides personalized embryo transfer as a treatment.
Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction
Genomewide gene expression profiling of cells recovered by uterine aspiration can identify robust candidate endometrial receptivity biomarkers while not disrupting implantation, enabling future validation by direct association with clinical outcome.
Adenomyosis shows an estrogen-dependent disruption of sympathetic nerve fibers, which seems to be cycle independent.
Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation
Among 536 midlife women assessed annually over 8 years, an adverse adipokine profile was associated with more vasomotor symptoms, particularly hot flashes, early in the menopause transition.
A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of gestational diabetes mellitus, particularly in heavier women.
Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis
Ovarian preservation has no statistically significant impact on the overall survival of young patients with early-stage endometrial cancer.
Reduced levels of hemopexin in the peritoneal fluid of patients with endometriosis compared with controls might indicate altered heme and iron metabolism in the peritoneal fluid of patients with endometriosis.
Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells
Treatment of endometriotic cells with histone deacetylase inhibitors romidepsin and SAHA reduce expression of GPER and the specific GPER antagonist (G-15) inhibits their proliferation.
Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior
Ectopic endometrial stromal cells from patients with endometriosis have similar immunophenotype but exhibit altered proliferation, invasion, adhesion, and cytokine production compared with their eutopic counterparts, suggesting the involvement of epigenome in their behavior.
Learning curve of hysteroscopic placement of tubal sterilization microinserts in 15 gynecologists in the Netherlands
A prospective, multicenter study to assess the learning curve of hysteroscopic sterilization in 15 gynecologists in the Netherlands showed a statistically significant decrease of procedure time with increasing experience.
Individual identification of oocyte dymorphisms may be a prognostic tool for blastocyst development and quality.
Early luteal phase endocrine profile is affected by the mode of triggering final oocyte maturation and the luteal phase support used in recombinant follicle-stimulating hormone–gonadotropin-releasing hormone antagonist in vitro fertilization cycles
In oocyte donors triggered with a bolus of GnRHa, gonadotropin and steroid levels during the early luteal phase differed significantly according to the type of luteal phase support used after triggering.
Review of public national assisted reproductive technology surveillance shows increasing exclusion of outcomes for cycles initiated between 2005 and 2010.
Bed rest after embryo transfer negatively affects in vitro fertilization: a randomized controlled clinical trial
Immediate ambulation after embryo transfer in in vitro fertilization obtained higher live-born infant rates than bed rest, which denotes the negative effect of bed rest after embryo transfer on treatment outcome.
An analysis of ketorolac use after oocyte retrieval over a 5-year period in a population undergoing in vitro fertilization found no differences in pregnancy outcomes.
Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer
A prospective series of 100 consecutive cycles using CCS demonstrated that the blastocyst selected by day 5 morphology has a substantial risk of aneuploidy.
Oocyte efficiency: does live birth rate differ when analyzing cryopreserved and fresh oocytes on a per-oocyte basis?
The biological efficiency of oocyte cryopreservation is comparable to fresh in vitro fertilization when live-birth rate is analyzed per mature oocyte retrieved.
Does intracytoplasmic sperm injection improve the fertilization rate and decrease the total fertilization failure rate in couples with well-defined unexplained infertility? A systematic review and meta-analysis
This meta-analysis of couples with well defined unexplained infertility undergoing IVF favors the use of intracytoplasmic sperm injection to increase fertilization rates and decrease the risk of total fertilization failure.
Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial
A randomized controlled trial demonstrates that blastocyst biopsy followed by rapid quantitative real-time polymerase chain reaction–based comprehensive chromosome screening and fresh embryo transfer significantly increases implantation and delivery rates.
Commentary on “Isolation of spermatozoa with low levels of fragmented DNA with the use of flow cytometry and sorting” by Ribeiro et al.
Isolation of spermatozoa with low levels of fragmented DNA with the use of flow cytometry and sorting
By combining the staining of apoptotic and dead spermatozoa with YO-PRO 1 and cytometric cell sorting, we obtained highly enriched populations of viable spermatozoa with reduced DNA fragmentation.
Impact of chemotherapy and radiotherapy for testicular germ cell tumors on spermatogenesis and sperm DNA: a multicenter prospective study from the CECOS network
Adjuvant treatments for testicular germ cell tumors have drastic effects on spermatogenesis and sperm chromatin quality; pretreatment values were recovered >12 months after >2 BEP cycles or after radiotherapy.
Varicocelectomy is associated with changes in the seminal plasma protein profile. These proteins may be important in the follow-up of patients with varicocele.
Claudin-11 and connexin-43 display altered spatial patterns of organization in men with primary seminiferous tubule failure compared with controls
Claudin-11 and connexin-43 protein organization is impaired in men with primary seminiferous tubule failure compared with controls, suggesting that disorganization of the Sertoli cell junctions is involved in spermatogenic failure.
Reflections on “A content analysis of posthumous sperm procurement protocols with considerations for developing an institutional policy” by Bahm et al.
Reflections on “Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction” by Chan et al.
Reflections on “Blastocyst biopsy with comprehensive chromosome screening and fresh embryo transfer significantly increases in vitro fertilization implantation and delivery rates: a randomized controlled trial” by Scott et al.
Reflections on “Increased risk of cancer among azoospermic men” by Eisenberg et al.
This document discusses the ethical considerations of cross-border reproductive care.
Appropriate use of medical therapy of early ectopic pregnancies is discussed.