Endometrial hormone receptor expression was altered during ovarian stimulation cycles and was independent from serum E2 levels.
Genotoxicity assessment of mouse oocytes by comet assay before vitrification and after warming with three vitrification protocols
Vitrification protocols containing 1,2-propanediol induced significant DNA damage on mouse oocytes before cooling and after warming.
Dead spermatozoa in raw semen samples impair in vitro fertilization outcomes of frozen-thawed spermatozoa
A high proportion of dead spermatozoa in raw semen samples increases the generation of endogenous reactive oxygen species and nuclear DNA fragmentation when frozen-thawed, impairing IVF ability and embryo development.
A randomized trial comparing the endometrial effects of daily subcutaneous administration of 25 mg and 50 mg progesterone in aqueous preparation
In mock donor-egg assisted reproduction technology cycles, daily subcutaneous administration of 25 mg or 50 mg progesterone reproduces the physiologic secretory transformation of the endometrium seen in the luteal phase.
Combined use of multiplex ligation-dependent probe amplification and automatic sequencing for identification of KAL1 defects in patients with Kallmann syndrome
KAL1 mutations are associated with a more severe phenotype. KAL1 exon deletions are especially frequent and more accurately detected by MLPA, as spurious pseudogene amplification can occur in absence of KAL1.
Children born after assisted reproduction show no consistent deficits in any specific neurodevelopmental outcomes, at any age. The neurodevelopment is overall comparable to that of children born after spontaneous conception.
A content analysis of posthumous sperm procurement protocols with considerations for developing an institutional policy
Through a content analysis of nine existing posthumous sperm procurement (PSP) policies, we identified the major components important to a thorough protocol and developed two competing models for PSP policies.
Antimüllerian hormone as predictor of reproductive outcome in subfertile women with elevated basal follicle-stimulating hormone levels: a follow-up study
In a prospective cohort study in subfertile women with elevated basal FSH levels, AMH is identified as a marker for actual fertility.
Endometrial integrin expression in women with recurrent implantation failure after in vitro fertilization and its relationship to pregnancy outcome
There is no evidence of abnormal endometrial integrin expression in women with recurrent implantation failure. The expression of integrins a1, a4, and aVb3 have no prognostic value in subsequent IVF treatment.
The endometrial receptivity array for diagnosis and personalized embryo transfer as a treatment for patients with repeated implantation failure
The endometrial receptivity array identifies the personalized window of implantation in patients with repeated implantation failure of endometrial origin and guides personalized embryo transfer as a treatment.
Discovery of biomarkers of endometrial receptivity through a minimally invasive approach: a validation study with implications for assisted reproduction
Genomewide gene expression profiling of cells recovered by uterine aspiration can identify robust candidate endometrial receptivity biomarkers while not disrupting implantation, enabling future validation by direct association with clinical outcome.
Adenomyosis shows an estrogen-dependent disruption of sympathetic nerve fibers, which seems to be cycle independent.
Adipokines, adiposity, and vasomotor symptoms during the menopause transition: findings from the Study of Women's Health Across the Nation
Among 536 midlife women assessed annually over 8 years, an adverse adipokine profile was associated with more vasomotor symptoms, particularly hot flashes, early in the menopause transition.
A common gene variant in STK11 is associated with metabolic risk markers and diabetes during gestation
In pregnant women, the G allele for the rs8111699 variant in STK11 is associated with a more favorable metabolic phenotype and may protect against the development of gestational diabetes mellitus, particularly in heavier women.
Safety of ovarian preservation in young patients with early-stage endometrial cancer: a retrospective study and meta-analysis
Ovarian preservation has no statistically significant impact on the overall survival of young patients with early-stage endometrial cancer.
Reduced levels of hemopexin in the peritoneal fluid of patients with endometriosis compared with controls might indicate altered heme and iron metabolism in the peritoneal fluid of patients with endometriosis.
Histone deacetylase inhibitors down-regulate G-protein-coupled estrogen receptor and the GPER-antagonist G-15 inhibits proliferation in endometriotic cells
Treatment of endometriotic cells with histone deacetylase inhibitors romidepsin and SAHA reduce expression of GPER and the specific GPER antagonist (G-15) inhibits their proliferation.
Eutopic and ectopic stromal cells from patients with endometriosis exhibit differential invasive, adhesive, and proliferative behavior
Ectopic endometrial stromal cells from patients with endometriosis have similar immunophenotype but exhibit altered proliferation, invasion, adhesion, and cytokine production compared with their eutopic counterparts, suggesting the involvement of epigenome in their behavior.
Learning curve of hysteroscopic placement of tubal sterilization microinserts in 15 gynecologists in the Netherlands
A prospective, multicenter study to assess the learning curve of hysteroscopic sterilization in 15 gynecologists in the Netherlands showed a statistically significant decrease of procedure time with increasing experience.
Individual identification of oocyte dymorphisms may be a prognostic tool for blastocyst development and quality.