We found significantly lower platelet and higher endothelial circulating microparticles in 124 women with previous unexplained pregnancy loss compared with 273 healthy parous controls.

Embryos cryopreserved after reaching blastocyst stage on day 7 were compared to those cryopreserved on days 5 and 6. Day 7 blastocysts have lower but clinically important pregnancy rates.

In vitro maturation (IVM) of oocytes followed by a “freeze-all” embryo strategy results in promising clinical outcomes in patients with polycystic ovary syndrome and circumvents the potential problem of suboptimal endometrial quality in IVM cycles.

The follicle transcriptomes after human chorionic gonadatropin and gonadotropin-releasing hormone agonist triggering present significant differences. The top biofunctions represented by the differentially expressed genes were steroidogenesis and angiogenesis in cumulus and mural granulosa cells, respectively.

The fertilization rate and embryo development of IVM oocytes after intracytoplasmic sperm injection (ICSI) using testicular spermatozoa was lower than that of sibling in vivo-matured oocytes.

Human cadaver testes were infused with 99mtechnetium-labeled green fluorescent protein-positive testicular cells. This study shows that injecting a cell suspension in seminiferous tubules is possible, though further optimization is required.

Fresh testicular spermatozoa obtained at different time periods before oocyte retrieval and those cryopreserved yield similar pregnancy rates in ICSI cycles.

Sperm retrieval and cryopreservation is possible in adolescents with Klinefelter syndrome who are actively being treated with topical testosterone replacement therapy.

Spinal cord injury is responsible for alterations in the seminal protein profile, leading to enrichment of a number of different gene ontology functions that may account for decreased fertility.

Basic semen parameters are consistent through 34 years of age. Thereafter, ejaculate volume, sperm numbers, motility, proportions of sperm of normal morphology, and the ratio of Y- to X-bearing sperm decline.

Global levels of sperm DNA methylation are significantly altered through the process of paternal aging.

Reflections on “Successful testicular sperm retrieval in adolescents with Klinefelter syndrome treated with at least 1 year of topical testosterone and aromatase inhibitor” by Mehta et al.

Reflections on “Differential seminal plasma proteome according to semen retrieval in men with spinal cord injury” by da Silva et al.

Reflections on “Paternal aging and associated intraindividual alterations of global sperm 5-methylcytosine and 5-hydroxymethylcytosine levels” by Jenkins et al.

Human embryonic stem cell (hESC) research is an ethically acceptable disposition for human embryos in excess of those needed to meet the fertility needs of patients.

Reducing exposure to toxic environmental agents is a critical area of intervention for obstetricians, gynecologists, and other reproductive health care professionals.

Multiple pregnancy remains the most common complication of ART. The incidence of high-order multiple (HOM) pregnancies (triplets and greater) increased fivefold within 18 years and the total number peaked a decade ago. The incidence of twins and HOMs remains high but the proportion due to ART is much less than previously suspected, and the relative contribution of other factors greater.

The authors discuss the “olive tree” metaphor, which emphasizes and helps promote the concept that reproductive damage done by environmental toxins such as tobacco smoke is not definitive.

Uterine transplantation is under investigation for the treatment of uterine factor infertility. Before the transplant becomes standard practice, an ethical framework should be established.

This Conceptions addresses personalized medicine in assisted reproductive technology.