This editorial discusses how a newly formatted IVF registry must adapt to the recent dramatic increase of “freeze all” cycles aimed toward increased patient safety, enhanced pregnancy results, and improved pregnancy outcomes to allow preimplantation genetic screening, and as a new approach for low prognosis couples.
In clinical guidelines for fertility preservation counseling in male cancer patients, issues of cell damage, contraception, and storage need to be highlighted before and after treatment as part of survivorship.
Chemotherapy treatment in men negatively impacts the male reproductive tract, and damage can potentially be transmitted to subsequent generations. Sensitive molecular biomarkers of injury are needed to ensure recovery of reproductive health.
Because the reproductive risks of using sperm after chemotherapy or radiotherapy are not clear, additional research is required to develop clinical guidelines for conception in the posttreatment period.
Short- and long-term effects of radiotherapy, cytotoxic cancer chemotherapy, and biologic targeted therapies on human spermatogenesis are summarized and interpreted based on kinetics of spermatogenesis and recovery from stem cells.
Cancer treatments are detrimental to spermatogenesis. This series reviews effects of anticancer therapies on male fertility, current and future approaches to determine sperm health, and gives recommendations for patient management.
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