Clinical pregnancy after uterus transplantation

The first clinical pregnancy after uterus allotransplantation is presented.

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Authors

Munire Erman Akar, M.D., Omer Ozkan, M.D., Batu A. Uraz, M.D., Kerem Dirican, Ph.D., Mehmet Cincik, M.D., Inanc Mendilcioglu, M.D., Mehmet Simsek, M.D., Filiz Gunseren, M.D., Huseyin Kocak, M.D., Akif Ciftcioglu, M.D., Omer Gecici, M.D.

Volume 100, Issue 5, Pages 1358-1363, November 2013

Abstract

Objective:

To present the first clinical pregnancy after uterus transplantation.

Design:

Case study.

Setting:

Tertiary center.

Patient(s):

A 23-year-old Mayer-Rokitansky-Kuster-Hauser syndrome patient with previous vaginal reconstruction and uterus transplantation.

Intervention(s):

Eighteen months after the transplant, the endometrium was prepared for transfer of the thawed embryos.

Main Outcome Measure(s):

Implantation of embryo in an allografted human uterus.

Result(s):

The first ET cycle with one day 3 thawed embryo resulted in a biochemical pregnancy. The second ET cycle resulted in a clinical pregnancy confirmed with transvaginal ultrasound visualization of an intrauterine gestational sac with decidualization.

Conclusion(s):

We have presented the first clinical pregnancy in a patient with absolute uterine infertility after uterus allotransplantation. Although the real success is the delivery of a healthy near-term baby, this clinical pregnancy is a great step forward and a proof of concept that the implantation phase works.

Read the full text at: http://www.fertstert.org/article/S0015-0282(13)00727-9/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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