Rectal shaving using PlasmaJet in deep endometriosis of the rectum
The technique described in this video article may represent a step toward a more complete removal of endometriotic implants and better colorectal outcomes.
November 2013
All the papers from the November 2013 issue of Fertility and Sterility.
A tumor necrosis factor α inhibitor reduces the embryotoxic effects of endometriotic peritoneal fluid
The abundant TNF-a in the peritoneal fluid of women with endometriosis plays an important role in endometriosis-induced embryotoxicity. The TNF-a inhibitors could potentially be used to treat endometriosis-related infertility.
Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1 5 8 signaling
Bone morphogenetic protein 4 increased oocyte formation from adult mouse ovary-derived oogonial stem cells via activation of Smad1/5/8 signaling and key meiosis commitment genes.
Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions
This study demonstrates for the first time a selective vascular disrupting effect of CA4P on endometriotic lesions, indicating that vascular disrupting agents may be suitable for the therapy of endometriosis.
Comparative gene expression profiling of adult mouse ovary derived oogonial stem cells supports a distinct cellular identity
Oogonial stem cells exhibited a gene expression profile partially overlapping with, but distinct from, other stem cells and germ cells, and they showed altered numbers during the reproductive cycle inversely related to meiotic commitment.
Growth differential factor 9 inhibits testosterone production in mouse theca interstitial cells
Growth differential factor-9 can inhibit the production of testosterone in mouse theca interstitial cells and suppress corresponding gene expression.
Developmental exposure of fetal ovaries and fetal germ cells to endometriosis in an endometriosis model causes differential gene expression in the preimplantation embryos of the first generation and second generation embryos
Fetal and fetal germ cell exposure to endometriosis in utero alters gene expression in first- and second-generation eight-cell embryos.
Multidrug resistant transport activity protects oocytes from chemotherapeutic agents and changes during oocyte maturation
Oocytes have a vast repertoire of multidrug-resistant transporters. These protective effluxers change overall activity during maturation, and inhibition of these transporters increases cell susceptibility to toxicants.
Hyperprolactinemia changes the sulfated glycosaminoglycan amount on the murine uterus during the estrous cycle
Metoclopramide-induced hyperprolactinemia changed the amounts of murine uterine chondroitin, dermatan, and heparan sulfate during the estrous cycle.
Progesterone and heparin binding epidermal growth factor like growth factor regulate the expression of tight junction protein Claudin 3 during early pregnancy
The spatiotemporal expression and regulatory patterns of the tight junction protein Claudin-3 during embryo implantation using mouse and cell culture models.
Metformin reduces the expression of corticotrophin releasing hormone and urocortin in the endometrium of healthy women
Metformin administration in normally cycling women may decrease the production of CRH and UCN in endometrium during the midluteal phase of the menstrual cycle.
2 Methoxyestradiol in the human corpus luteum throughout the luteal phase and its influence on lutein cell steroidogenesis and angiogenic activity
The levels of 2-methoxyestradiol are elevated in late luteal tissue and reduce the angiogenic vascular endothelial growth factor action in granulosa lutein cells.
Predictive factors of health related quality of life in patients with polycystic ovary syndrome a structural equation modeling approach
We discuss health-related quality of life in patients with polycystic ovary syndrome. Mediating factors, especially psychological distress, self-esteem, body image and sexual function play an important role and should be taken into consideration and adequately treated if present.
Management of the first in vitro fertilization cycle for unexplained infertility cost effectiveness analysis of split in vitro fertilization intracytoplasmic sperm injection
Conventional IVF may be the preferred insemination method in the initial treatment of couples with unexplained infertility, but split IVF-ICSI becomes preferable if more than one IVF cycle is necessary.
Progesterone luteal support after ovulation induction and intrauterine insemination a systematic review and meta analysis
Progesterone for luteal support after ovulation induction IUI was associated with increased likelihood of pregnancy and live birth in gonadotropin cycles but not in clomiphene citrate (CC) cycles.
Cellular immune environment in endometrial polyps
Endometrial polyps in premenopausal women demonstrate a range of immunologic disturbances, including mast cell and regulatory T-cell infiltration. These likely contribute to symptoms of infertility and abnormal bleeding.
Clinical pregnancy after uterus transplantation
The first clinical pregnancy after uterus allotransplantation is presented.
Evaluation of cryopreserved ovarian tissue from prepubertal patients after long term xenografting and exogenous stimulation
After long-term xenotransplantation and exogenous stimulation, a high pool of quiescent follicles and follicular development up to the antral stage were evidenced in cryopreserved ovarian tissue from prepubertal patients.
What do reproductive age women who undergo oocyte cryopreservation think about the process as a means to preserve fertility
Women electing oocyte cryopreservation know about age-related infertility yet continue to delay childbearing. Fertility preservation can increase a woman’s security regarding her reproductive future.
Continuous versus cyclic use of oral contraceptives after surgery for symptomatic endometriosis A prospective cohort study
Continuous use of oral contraceptives after surgery is associated with a statistically significant reduction in dysmenorrhea, non-menstrual pelvic pain, and endometrioma recurrence.
Deep endometriosis and bladder and detrusor functions in women without urinary symptoms A pilot study through an unexplored world
Deep endometriosis may impair visceral and motor function owing to fibrotic neural involvement. Our pilot study seems to showthatdetrusor function could be significantly compromised, even in asymptomatic women.
Impact of subclinical hypothyroidism in women with recurrent early pregnancy loss
The high prevalence of subclinical hypothyroidism among women with recurrent early pregnancy loss did not appear to impact the live-birth rates in this population.
Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor assessing timing of miscarriage and partner risk
M2/ANXA5 carriers show a trend of maximal recurrent pregnancy loss risk in the 10th to 15th week of gestation with a confirmed partner risk.
Additive effect of factors related to assisted conception on the reduction of maternal serum PAPP A concentrations and the increased false positive rates in first trimester Down syndrome screening
Among assisted conceptions, only nondonor in vitro fertilization/intracytoplasmic sperm injection singleton pregnancies need adjustments of the PAPP-A in first-trimester Down syndrome screening.
Effect of single dose methotrexate on ovarian reserve in women with ectopic pregnancy
We studied the effect of single-dose systemic methotrexate treatment on ovarian reserve in ectopic pregnancy and concluded that methotrexate treatment has no effect on short-term ovarian reserve.
The effect of the biochemical marker soluble human leukocyte antigen G on pregnancy outcome in assisted reproductive technology a multicenter study
Data from 2,040 intracytoplasmic sperm injection patients combining embryo morphology with expression of sHLA-G (a noninvasive embryo marker) show improved pregnancy outcome and the theoretical potential to reduce multiple pregnancies.
Dual trigger with combination of gonadotropin releasing hormone agonist and human chorionic gondadotropin significantly improves live birth rate for normal responders in GnRH antagonist cycles
Dual trigger with gonadotropin-releasing hormone (GnRH) agonist and human chorionic gonadotropin improves implantation, clinical pregnancy, and live-birth rates for normal responders in GnRH-antagonist IVF-ICSI cycles.
Thin endometrium in donor oocyte recipients Enigma or obstacle for implantation
Thin endometrium does not seem to influence oocyte donation outcome.
Does culture medium influence offspring birth weight
After analyzing the influence of different embryo culture media on the weight of the newborn, the results do not show any relationship between them.
Hatching of in vitro fertilized human embryos is influenced by fertilization method
We describe two distinct mechanisms of in vitro hatching related to fertilization method and demonstrate that hatching pattern is associated with fertilization method, but not with clinical pregnancy.
Using the ovarian sensitivity index to define poor normal and high response after COH in the long GnRH agonist protocol Suggestions for a new principle to solve an old problem
Poor, normal, and high ovarian responses were defined with the use of the ovarian sensitivity index, the ratio between oocyte yield and total dose of FSH, in a large unselected IVF cohort.
Microbiota of the seminal fluid from healthy and infertile men
High numbers of diverse kinds of bacteria were present in the semen of both sperm donors and infertility patients. There were no significant differences between these two groups based on community composition.
Cysteine rich secretory protein 1 in seminal plasma potential biomarker for the distinction between obstructive and nonobstructive azoospermia
Seminal CRISP1 was measured to distinguish between obstructive and nonobstructive azoospermia. The receiver operating characteristic plots demonstrated a high diagnostic accuracy for CRISP1 to diagnose the cause of azoospermia.
Fresh semen quality in ejaculates produced by nocturnal emission in men with idiopathic anejaculation
Sperm motility and normal morphology were higher in idiopathic anejaculation patients who collected their sperm by nocturnal emissions than in those who collected their sperm by penile vibratory stimulation or electroejaculation.
Methylation changes in mature sperm deoxyribonucleic acid from oligozoospermic men assessment of genetic variants and assisted reproductive technology outcome
This study indicates methylation errors in oligozoospermia. We identified variants in DNMT3A and DNMT3L in men with altered methylation, but we did not find any association with DNA methylation defects and ART outcome.
Detection of oncogenic human papillomavirus genotypes on spermatozoa from male partners of infertile couples
Standard sperm evaluation, human papillomavirus (HPV) DNA detection, and in situ hybridization analysis were performed in 308 patients undergoing IVF procedures. Oncogenic HPV genotypes were detected on spermatozoa from asymptomatic subjects.
Vascular disrupting and antiangiogenic agents Better together than on their own
Reflections on “Vascular disrupting effects of combretastatin A4 phosphate on murine endometriotic lesions” by Feng et al.
Live birth after uterine transplantation remains challenging
Reflections on “Clinical pregnancy after uterus transplantation” by Akar et al.
Fertility preservation and reproduction in patients facing gonadotoxic therapies a committee opinion
Ethical considerations of preserving fertility after gonadotoxic treatment are discussed.
Fertility preservation in patients undergoing gonadotoxic therapy or gonadectomy a committee opinion
This document describes the responsibilities and strategies for fertility preservation in patients undergoing gonadotoxic medical therapy or radiation therapy or gonadectomy.