The abundant TNF-a in the peritoneal fluid of women with endometriosis plays an important role in endometriosis-induced embryotoxicity. The TNF-a inhibitors could potentially be used to treat endometriosis-related infertility.
This study demonstrates for the first time a selective vascular disrupting effect of CA4P on endometriotic lesions, indicating that vascular disrupting agents may be suitable for the therapy of endometriosis.
Oogonial stem cells exhibited a gene expression profile partially overlapping with, but distinct from, other stem cells and germ cells, and they showed altered numbers during the reproductive cycle inversely related to meiotic commitment.
Oocytes have a vast repertoire of multidrug-resistant transporters. These protective effluxers change overall activity during maturation, and inhibition of these transporters increases cell susceptibility to toxicants.
We discuss health-related quality of life in patients with polycystic ovary syndrome. Mediating factors, especially psychological distress, self-esteem, body image and sexual function play an important role and should be taken into consideration and adequately treated if present.
Conventional IVF may be the preferred insemination method in the initial treatment of couples with unexplained infertility, but split IVF-ICSI becomes preferable if more than one IVF cycle is necessary.
Endometrial polyps in premenopausal women demonstrate a range of immunologic disturbances, including mast cell and regulatory T-cell infiltration. These likely contribute to symptoms of infertility and abnormal bleeding.
After long-term xenotransplantation and exogenous stimulation, a high pool of quiescent follicles and follicular development up to the antral stage were evidenced in cryopreserved ovarian tissue from prepubertal patients.
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