We demonstrate our approach to microsurgical subinguinal varicocelectomy. A number of useful surgical techniques are highlighted and summarized throughout the video.
All the papers from the December 2013 issue of Fertility and Sterility.
Laparoscopically assisted biomaterial graft for reconstruction in congenital atresia of vagina and cervix
A combined laparoscopic and vaginal procedure with biomaterial graft couldbe an effective alternative in selected women with atresia of cervix and vagina.
Addition of nitrous oxide to the carbon dioxide pneumoperitoneum strongly decreases adhesion formation and the dose dependent adhesiogenic effect of blood in a laparoscopic mouse model
The addition of nitrous oxide to the carbon dioxide pneumoperitoneum strongly prevents adhesion formation in a laparoscopic mouse model, with a maximal effect from 5%–10% upward. Blood dose-dependently increases adhesion formation.
Delta like ligand 4 regulates vascular endothelial growth factor receptor 2 driven luteal angiogenesis through induction of a tip stalk phenotype in proliferating endothelial cells
Blockade of Dll4 in an in vivo rodent model shows that VEGFR2-mediated sprouting during luteal angiogenesis is modulated by the Dll4/Notch-1 pathway, which induces a tip/stalk phenotype.
Chronic exposure to a low concentration of bisphenol A during follicle culture affects the epigenetic status of germinal vesicles and metaphase II oocytes
Chronic follicle culture exposure to low bisphenol A affects imprinting and posttranslational histone modifications in mouse oocytes, epigenetic aberrations that might contribute to aneuploidy, altered gene expression, and epigenetic disease.
Findings in rats suggest that parental sleep influences the reproductive capability of the F1 offspring.
Polycystic ovary syndrome and nonalcoholic fatty liver in obese adolescents association with metabolic risk profile
The relationship between liver fat and metabolic risk was examined in obese adolescent girls with PCOS. This article demonstrates that worsening liver fat is associated with advancing age, increasing abdominal adiposity, worsening insulin sensitivity, and dyslipoproteinemia.
An assessment of current clinical attitudes toward letrozole use in reproductive endocrinology practices
A survey of SART clinic members reveals that 77% of respondents use letrozole in clinical practice. The majority of letrozole is used in patients who fail to ovulate with clomiphene citrate.
No relationship could be demonstrated between blood type and risk of diminished ovarian reserve in an analysis of 305 patients undertaking in vitro fertilization.
Dietary isoflavone intake is associated with elevated SHBG concentrations, but not with reproductive hormones or anovulation.
Mifepristone was effective in treating leiomyomas, and 2.5 mg of mifepristone administered daily for 3 or 6 months was the optimal dosage for leiomyoma treatment.
The menstrual pictogram (SAP-c version) is a potential diagnostic tool for heavy menstrual bleeding, and would be suitable for testing treatment effects in clinical trials.
Carbon dioxide versus normal saline as distension medium for diagnostic hysteroscopy a systematic review and meta analysis of randomized controlled trials
Normal saline is superior to CO2 as distension medium for diagnostic hysteroscopy. A high quality trial is required to validate these findings.
Short term effects of salpingectomy during laparoscopic hysterectomy on ovarian reserve a pilot randomized controlled trial
Salpingectomy at the time of hysterectomy with ovarian preservation does not have any short-term effects on ovarian reserve.
Diminished effect of maternal age on implantation after preimplantation genetic diagnosis with array comparative genomic hybridization
Here we describe biopsy and chromosome screening with the use of array comparative genomic hybridization with biopsy at day 3 or day 5/6 of embryo development. The main outcome markers were implantation rate, ongoing pregnancy rate, and pregnancy loss rate.
Potential biomarkers of nonobstructive azoospermia identified in microarray gene expression analysis
The potential biomarkers of azoospermia and molecular indicators that could determine particular stages of impaired spermatogenesis can be identified with GeneChip Human Gene 1.0 ST arrays.
Safety and feasibility of performing two consecutive ovarian stimulation cycles with the use of letrozole gonadotropin protocol for fertility preservation in breast cancer patients
Performing consecutive cycles of ovarian stimulation with letrozole and gonadotropin protocol for fertility preservation to maximize oocyte yield before chemotherapy is a feasible approach in women with breast cancer.
Random-start controlled ovarian stimulation (COS) protocols are as effective as conventional-start COS in fertility preservation and provide a significant advantage by decreasing the total time for embryo/oocyte cryopreservation.
A third of women assessed prospectively during pregnancy and after delivery reported hot flashes during pregnancy/postpartum, for which depressive symptoms, lower education, and higher body mass index were predictors.
Ovulation inducing drugs and ovarian cancer risk results from an extended followup of a large United States infertility cohort
Our findings were generally reassuring in not confirming a link between ovulation-inducing drugs and ovarian cancer; risk was increased, however, among women who, despite having used clomiphene citrate, remained nulligravid.
Identification of multiple and distinct defects in prostaglandin biosynthetic pathways in eutopic and ectopic endometrium of women with endometriosis
Eutopic and ectopic endometrial tissues display distinct anomalies in PG biosynthesis and catabolism pathways.
In endometriosis, local activation of estrogens appears to be important. Steroid sulfatase and 17b-hydroxysteroid dehydrogenase type 1 inhibitors may therefore prove useful to treat the disease.
Accuracy of a home based device for giving an early estimate of pregnancy duration compared with reference methods
A home pregnancy test with weeks since ovulation results had 93% agreement with time since ovulation and 99% with ultrasound, which provides an estimate more accurate than last menstrual period and earlier than ultrasound.
Peripheral natural killer cell activity as a predictor of recurrent pregnancy loss a large cohort study
Elevated peripheral blood NK cell activity was found to not be an independent risk factor for subsequent miscarriage.
Progesterone elevation does not compromise pregnancy rates in high responders a pooled analysis of in vitro fertilization patients treated with recombinant FSH GnRH antagonist in six trials
Incidence of elevated P increases with ovarian response, and elevated P (>1.5 ng/mL) is independently associated with a decreased chance of pregnancy in low to normal, but not high, responders.
Obstetric and perinatal outcomes in singleton pregnancies resulting from the transfer of blastocyst stage versus cleavage stage embryos generated through in vitro fertilization treatment A systematic review and meta analysis
Singleton pregnancies arising from the transfer of embryos at blastocyst-stage in IVF appear to have higher risk of preterm and very preterm delivery when compared with cleavage-stage transfer.
Thin endometrial stripe does not affect likelihood of achieving pregnancy in clomiphene citrate intrauterine insemination cycles
This study did not find any significant correlation between preovulatory endometrial stripe thickness and likelihood of achieving pregnancy in clomiphene citrate/intrauterine insemination cycles.
We define the times associated with morphological changes that occur in embryo development based on time lapse. Subgroups of embryos were compared and related with blastocyst formation and implantation.
The effectiveness of GnRH antagonist in poor ovarian responders undergoing in vitro fertilization a systematic review and meta analysis
In poor responders undergoing in vitro fertilization, the clinical efficacy of a gonadotropin-releasing hormone (GnRH) antagonist was similar to that of a GnRH agonist.
Does methotrexate administration for ectopic pregnancy after in vitro fertilization impact ovarian reserve or ovarian responsiveness
The IVF cycles before and after methotrexate administration to 66 women were compared. Methotrexate does not compromise ovarian reserve, ovarian responsiveness, or IVF success in subsequent cycles.
Preliminary investigation of the impact of anticentromere antibody on oocyte maturation and embryo cleavage
Decreased percentage of mature oocytes and rate of embryo cleavage were found in the ACA[+]/ANA[+] group as compared with the ACA/ANA[+] group.
Second try who returns for additional assisted reproductive technology treatment and the effect of a prior assisted reproductive technology birth
Live-birth rates were significantly higher for try 2 compared with try 1 for autologous fresh cycles, averaging 7.7 percentage points higher over five cycles.
In this cross-sectional study of healthy young men, dietary intakes of the carotenoids b-carotene and lutein were associated with higher sperm motility, while lycopene intake was associated with better morphology.
DNA fragmentation of human sperm can be detected by ligation mediated real time polymerase chain reaction
Ligation-mediated polymerase chain reaction (PCR) combined with real-time PCR is a useful tool for detecting DNA fragmentation as a parameter of sperm quality in human samples.
Semen cryopreservation for men banking for oligospermia, cancers, and other pathologies: prediction of post-thaw outcome using basal semen quality
We demonstrate the ability of prefreeze semen quality to predict cryosurvival in terms of sensitivity and precision. This information allows appropriate counseling about the future possibilities of fertility for the patient.
Association of aberrant expression of sex determining gene fibroblast growth factor 9 with Sertoli cell only syndrome
Testicular fibroblast growth factor 9 (FGF9) is expressed in adult Leydig cells, and its expression is significantly decreased in patients with Sertoli cell–only syndrome. A promoter polymorphism of FGF9 contributes to its aberrant expression.
Finasteride may cause reduced sperm counts in some men, but sperm counts improve dramatically for most after discontinuation. Finasteride should be used with caution in men who desire fertility.
rs189037 a functional variant in ATM gene promoter is associated with idiopathic nonobstructive azoospermia
Our case–control study, involving 229 idiopathic nonobstructive azoospermia (INOA) patients and 236 fertile male controls, indicates that rs189037(G>A) in ATM gene increases INOA risk, possibly through affecting ATM expression.
Normal live births after intracytoplasmic sperm injection in a man with the rare condition of Eagle Barrett syndrome prune belly syndrome
Intracytoplasmic sperm injection (ICSI) with sperm from a man with Eagle-Barrett syndrome (EBS) resulted in the births of two normal healthy male infants, suggesting that EBS is not transmitted to male offspring.