More studies investigating the role of melatonin supplementation during controlled ovarian stimulation for improving assisted reproductive technology outcomes are still needed before recommending its use in clinical practice.
The long gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist regimens offer suitable choices for women with poor ovarian response undergoing IVF. The short GnRH agonist regimen is the least effective for poor responders.
Genes related to endometrial receptivity were analyzed on 25 endometrial samples after GnRH-a triggering and different luteal support protocols; adding LH/hCG activity more closely resembles the expression after hCG triggering.
Frozen-thawed single-blastocyst transfers were associated with lower odds of adverse neonatal outcomes than fresh transfers, but with higher odds of placenta accreta and pregnancy-induced hypertension.
By using Focal Plane Array Fourier transform infrared spectroscopy, evidence of damage from aging on human oocytes was pinpointed in the composition and distribution of the principal biocomponents (proteins, lipids, carbohydrates, and nucleic acids).
Luteal-phase ovarian stimulation reveals a new approach for collecting competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in subsequent frozen embryo transfer cycles.
This study establishes association of acetyl a-tubulin with asthenozoospermia, suggests the isoforms determining the acetylation, and provides insight into potential mechanism of transcriptional regulation of a-tubulin isoforms.
Microarray and real-time polymerase chain reaction studies reveal that microRNAs are differentially expressed in normal versus different testicular histopathologic patterns and have therapeutic potential for the development of biomarkers for male infertility.
In Canada, testosterone is not commonly used by men presenting for fertility investigation (1.3%). Testosterone cessation generally resulted in an increase in sperm counts. A subset of men remained azoospermic.
Sperm chromatin dispersion (SCD) and TUNEL are poorly correlated for estimating DNA damage in men with unexplained infertility. SCD discriminates normal and abnormal sperm DNA damage with up to 69% accuracy when compared with TUNEL.
Cigarette smoking is associated with abnormalities in histone-to-protamine transition independent of semen quality, and interferes with the mRNA expression of protamines in human sperm and TM3 cell lines.
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