Cold loop hysteroscopic myomectomy is a safe, effective procedure that is associated with a low rate of postsurgical intrauterine adhesions.

Estradiol and tamoxifen enhance invasion of both adenomyosis-derived stromal cells and control stromal cells when grown on collagen or in coculture with myocytes.

As a single metric, follicle number per ovary best predicts PCOS. Ovarian volume and follicle number per single cross-section, together, provide the closest level of diagnostic potential to follicle number per ovary alone. Stromal measurements have little to no diagnostic potential.

In normal and polycystic ovary syndrome (PCOS) women, inhibin B production was decreased following recombinant hCG administration. These findings suggest that in PCOS women, androgen excess is not enhanced by LH-stimulated inhibin B production.

At 10-year follow-up, laparoscopic electrocautery in women with CC-resistant PCOS does not affect pregnancy complications or metabolic or cardiovascular disease later in life compared with ovulation induction with gonadotropins.

Baseline characteristics from 750 women with PCOS and their male partners from a multicenter trial show the groups to be well matched with body mass index exacerbating metabolic and reproductive parameters.

Motivation for sperm donation is multifaceted and primarily based on economic compensation and altruism. The attitudes toward aspects of donation remain liberal and unchanged among Danish sperm donors.

For the first time, we report oocyte donors’ comprehension of the process and risks associated with oocyte donation as assessed by the Egg Donor Informed Consent Tool (EDICT).

Proinflammatory cytokines are increased in menstrual effluents of women with chronic endometritis (CE). A test measuring interleukin-6 and tumor necrosis factor a might offer a reliable tool for screening CE.

Adenomyosis contributes to symptomatology in women with concomitant adenomyosis and leiomyomas

The exceedingly low prevalence of uniparental disomy (UPD) indicates that routine preimplantation screening may not be necessary and that UPD is not a reasonable explanation to support hypothesized embryonic self-correction.

Antimullerian hormone may be the optimal screening tool for assessing ovarian reserve in childhood cancer survivors, allowing for timely initiation of pubertal induction and fertility counseling.

Oocyte cryopreservation was recently approved by the American Society for Reproductive Medicine (ASRM); however, most Society for Assisted Reproductive Technology (SART) member fertility clinics do not follow the SART/ASRM guidelines for web advertising of the procedure.

Male environmental BPA exposure may have an adverse influence on semen quality parameters, but does not affect embryo development at the blastocyst stage after IVF or intracytoplasmic sperm injection (ICSI).

As in two previous studies, a measure of cervical neoplasia was associated with a decreased risk of fibroids (patients with a history of cervical treatment had a 39% adjusted reduction in odds).

In a healthy, multiethnic sample, a significant race/ethnicity-by-age interaction was observed, suggesting African-American women may have lower AMH at younger ages but experience less of a reduction in AMH with age.

In this international econometric study of assisted reproduction technology treatment, we show that the cost that consumers pay for treatment relative to income predicts the level of access and number of embryos transferred.

Trials sponsored by industry and nonindustry are systematically different, with industry supporting more placebo-controlled phase II/III trials. Trials launched without prior published preclinical results do not seem to fare well.

Maternal cell contamination often obscures accurate chromosome analysis of miscarriages, but testing can differentiate the maternal from fetal genome, thus improving detection of the true karyotype of pregnancy tissue.

A study comparing outcomes of induced versus spontaneous twins reveals higher risks of first-trimester bleeding, gestational diabetes, discordant growth, and cesarean section, with no other significant differences in obstetrical and puerperal complications.

Elevated expression levels of matrix metalloproteinase 9 in placental villi and of tissue inhibitor of metalloproteinase 2 in decidua are associated with prolonged bleeding after medical abortion.

In a retrospective analysis a slightly, but not significant, lower incidence of ectopic pregnancies was found in frozen ET cycles than in fresh IVF ET cycles.

More studies investigating the role of melatonin supplementation during controlled ovarian stimulation for improving assisted reproductive technology outcomes are still needed before recommending its use in clinical practice.

The long gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist regimens offer suitable choices for women with poor ovarian response undergoing IVF. The short GnRH agonist regimen is the least effective for poor responders.

Genes related to endometrial receptivity were analyzed on 25 endometrial samples after GnRH-a triggering and different luteal support protocols; adding LH/hCG activity more closely resembles the expression after hCG triggering.

The AMH assays reduced the cancellation rate after ovarian stimulation and helped some patients not to begin IVF stimulation because of their low AMH level.

Frozen-thawed single-blastocyst transfers were associated with lower odds of adverse neonatal outcomes than fresh transfers, but with higher odds of placenta accreta and pregnancy-induced hypertension.

By using Focal Plane Array Fourier transform infrared spectroscopy, evidence of damage from aging on human oocytes was pinpointed in the composition and distribution of the principal biocomponents (proteins, lipids, carbohydrates, and nucleic acids).

Luteal phase supportwith a newsubcutaneous progesterone preparation provided pregnancy rates similar to progesterone vaginal gel in IVF patients. Safety and tolerability profile were equivalent.

Luteal-phase ovarian stimulation reveals a new approach for collecting competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in subsequent frozen embryo transfer cycles.

This study establishes association of acetyl a-tubulin with asthenozoospermia, suggests the isoforms determining the acetylation, and provides insight into potential mechanism of transcriptional regulation of a-tubulin isoforms.

Polymorphisms in the folate-metabolizing genes could be associated with the risk of male infertility, but further studies having more statistical power are needed to investigate the association.

Microarray and real-time polymerase chain reaction studies reveal that microRNAs are differentially expressed in normal versus different testicular histopathologic patterns and have therapeutic potential for the development of biomarkers for male infertility.

The inflammatory status of the epididymis may be reflected by the abundance and activation status of dendritic cells in semen, which may affect sperm quality and fertility outcome.

In Canada, testosterone is not commonly used by men presenting for fertility investigation (1.3%). Testosterone cessation generally resulted in an increase in sperm counts. A subset of men remained azoospermic.

Sperm chromatin dispersion (SCD) and TUNEL are poorly correlated for estimating DNA damage in men with unexplained infertility. SCD discriminates normal and abnormal sperm DNA damage with up to 69% accuracy when compared with TUNEL.

Cigarette smoking is associated with abnormalities in histone-to-protamine transition independent of semen quality, and interferes with the mRNA expression of protamines in human sperm and TM3 cell lines.

Reflections on “Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome” by Christ et al.

Reflections on “The impact of consumer affordability on access to assisted reproductive technologies and embryo transfer practices: an international analysis” by Chambers et al.

Reflections on “An overview of the current status of clinical trials on endometriosis: issues and concerns” by Guo et al.