Does cold loop hysteroscopic myomectomy reduce intrauterine adhesions? A retrospective study
Cold loop hysteroscopic myomectomy is a safe, effective procedure that is associated with a low rate of postsurgical intrauterine adhesions.
January 2014
All the papers from the January 2014 issue of Fertility and Sterility.
Estradiol and tamoxifen enhance invasion of endometrial stromal cells in a three dimensional coculture model of adenomyosis
Estradiol and tamoxifen enhance invasion of both adenomyosis-derived stromal cells and control stromal cells when grown on collagen or in coculture with myocytes.
Follicle number not assessments of the ovarian stroma represents the best ultrasonographic marker of polycystic ovary syndrome
As a single metric, follicle number per ovary best predicts PCOS. Ovarian volume and follicle number per single cross-section, together, provide the closest level of diagnostic potential to follicle number per ovary alone. Stromal measurements have little to no diagnostic potential.
Decreased inhibin B responses following recombinant human chorionic gonadotropin administration in normal women and women with polycystic ovary syndrome
In normal and polycystic ovary syndrome (PCOS) women, inhibin B production was decreased following recombinant hCG administration. These findings suggest that in PCOS women, androgen excess is not enhanced by LH-stimulated inhibin B production.
Pregnancy complications and metabolic disease in women with clomiphene citrate-resistant anovulation randomized to receive laparoscopic electrocautery of the ovaries or ovulation induction with gonadotropins: a 10-year follow-up
At 10-year follow-up, laparoscopic electrocautery in women with CC-resistant PCOS does not affect pregnancy complications or metabolic or cardiovascular disease later in life compared with ovulation induction with gonadotropins.
The Pregnancy in Polycystic Ovary Syndrome Study II baseline characteristics and effects of obesity from a multicenter randomized clinical trial
Baseline characteristics from 750 women with PCOS and their male partners from a multicenter trial show the groups to be well matched with body mass index exacerbating metabolic and reproductive parameters.
Danish sperm donors across three decades Motivations and attitudes
Motivation for sperm donation is multifaceted and primarily based on economic compensation and altruism. The attitudes toward aspects of donation remain liberal and unchanged among Danish sperm donors.
Oocyte donors comprehension as assessed by the EDICT Egg Donor Informed Consent Tool
For the first time, we report oocyte donors’ comprehension of the process and risks associated with oocyte donation as assessed by the Egg Donor Informed Consent Tool (EDICT).
Interleukin 6 interleukin 1β and tumor necrosis factor α in menstrual effluents as biomarkers of chronic endometritis
Proinflammatory cytokines are increased in menstrual effluents of women with chronic endometritis (CE). A test measuring interleukin-6 and tumor necrosis factor a might offer a reliable tool for screening CE.
Clinical characteristics indicating adenomyosis coexisting with leiomyomas a retrospective questionnaire based study
Adenomyosis contributes to symptomatology in women with concomitant adenomyosis and leiomyomas
Uniparental disomy in the human blastocyst is exceedingly rare
The exceedingly low prevalence of uniparental disomy (UPD) indicates that routine preimplantation screening may not be necessary and that UPD is not a reasonable explanation to support hypothesized embryonic self-correction.
Antimullerian hormone as a measure of reproductive function in female childhood cancer survivors
Antimullerian hormone may be the optimal screening tool for assessing ovarian reserve in childhood cancer survivors, allowing for timely initiation of pubertal induction and fertility counseling.
What is the quality of information on social oocyte cryopreservation provided by websites of Society for Assisted Reproductive Technology member fertility clinics
Oocyte cryopreservation was recently approved by the American Society for Reproductive Medicine (ASRM); however, most Society for Assisted Reproductive Technology (SART) member fertility clinics do not follow the SART/ASRM guidelines for web advertising of the procedure.
Are urinary bisphenol A levels in men related to semen quality and embryo development after medically assisted reproduction
Male environmental BPA exposure may have an adverse influence on semen quality parameters, but does not affect embryo development at the blastocyst stage after IVF or intracytoplasmic sperm injection (ICSI).
Cervical neoplasia related factors and decreased prevalence of uterine fibroids among a cohort of African American women
As in two previous studies, a measure of cervical neoplasia was associated with a decreased risk of fibroids (patients with a history of cervical treatment had a 39% adjusted reduction in odds).
Race ethnic disparities in reproductive age An examination of ovarian reserve estimates across four race ethnic groups of healthy regularly cycling women
In a healthy, multiethnic sample, a significant race/ethnicity-by-age interaction was observed, suggesting African-American women may have lower AMH at younger ages but experience less of a reduction in AMH with age.
The impact of consumer affordability on access to assisted reproductive technologies and embryo transfer practices an international analysis
In this international econometric study of assisted reproduction technology treatment, we show that the cost that consumers pay for treatment relative to income predicts the level of access and number of embryos transferred.
An overview of the current status of clinical trials on endometriosis issues and concerns
Trials sponsored by industry and nonindustry are systematically different, with industry supporting more placebo-controlled phase II/III trials. Trials launched without prior published preclinical results do not seem to fare well.
Reliability of 46 XX results on miscarriage specimens A review of 1222 first trimester miscarriage specimens
Maternal cell contamination often obscures accurate chromosome analysis of miscarriages, but testing can differentiate the maternal from fetal genome, thus improving detection of the true karyotype of pregnancy tissue.
Impact of induced pregnancies in the obstetrical outcome of twin pregnancies
A study comparing outcomes of induced versus spontaneous twins reveals higher risks of first-trimester bleeding, gestational diabetes, discordant growth, and cesarean section, with no other significant differences in obstetrical and puerperal complications.
Elevated expression levels of matrix metalloproteinase 9 in placental villi and TIMP 2 in decidua are associated with prolonged bleeding after mifepristone misoprostol medical abortion
Elevated expression levels of matrix metalloproteinase 9 in placental villi and of tissue inhibitor of metalloproteinase 2 in decidua are associated with prolonged bleeding after medical abortion.
Slightly lower incidence of ectopic pregnancies in frozen embryo transfer cycles versus fresh in vitro fertilization embryo transfer cycles A retrospective cohort study
In a retrospective analysis a slightly, but not significant, lower incidence of ectopic pregnancies was found in frozen ET cycles than in fresh IVF ET cycles.
Melatonin supplementation during controlled ovarian stimulation for women undergoing assisted reproductive technology Systematic review and meta analysis of randomized controlled trials
More studies investigating the role of melatonin supplementation during controlled ovarian stimulation for improving assisted reproductive technology outcomes are still needed before recommending its use in clinical practice.
Long gonadotropin releasing hormone agonist versus short agonist versus antagonist regimens in poor responders undergoing IVF a randomized controlled trial
The long gonadotropin-releasing hormone (GnRH) agonist and GnRH antagonist regimens offer suitable choices for women with poor ovarian response undergoing IVF. The short GnRH agonist regimen is the least effective for poor responders.
Impact of final oocyte maturation using gonadotropin releasing hormone agonist triggering and different luteal support protocols on endometrial gene expression
Genes related to endometrial receptivity were analyzed on 25 endometrial samples after GnRH-a triggering and different luteal support protocols; adding LH/hCG activity more closely resembles the expression after hCG triggering.
Impact of antimullerian hormone assays on the outcomes of in vitro fertilization a prospective controlled study
The AMH assays reduced the cancellation rate after ovarian stimulation and helped some patients not to begin IVF stimulation because of their low AMH level.
Impact of frozen thawed single blastocyst transfer on maternal and neonatal outcome An analysis of 277042 single embryo transfer cycles from 2008 to 2010 in Japan
Frozen-thawed single-blastocyst transfers were associated with lower odds of adverse neonatal outcomes than fresh transfers, but with higher odds of placenta accreta and pregnancy-induced hypertension.
A new approach to evaluate aging effects on human oocytes Fourier transform infrared imaging spectroscopy study
By using Focal Plane Array Fourier transform infrared spectroscopy, evidence of damage from aging on human oocytes was pinpointed in the composition and distribution of the principal biocomponents (proteins, lipids, carbohydrates, and nucleic acids).
Subcutaneous progesterone versus vaginal progesterone gel for luteal phase support in in vitro fertilization a noninferiority randomized controlled study
Luteal phase supportwith a newsubcutaneous progesterone preparation provided pregnancy rates similar to progesterone vaginal gel in IVF patients. Safety and tolerability profile were equivalent.
Luteal phase ovarian stimulation is feasible for producing competent oocytes in women undergoing IVF ICSI treatment with optimal pregnancy outcomes in frozen thawed embryo transfer cycles
Luteal-phase ovarian stimulation reveals a new approach for collecting competent oocytes in women undergoing in vitro fertilization/intracytoplasmic sperm injection treatment, with optimal pregnancy outcomes in subsequent frozen embryo transfer cycles.
Acetylated alpha tubulin is reduced in individuals with poor sperm motility
This study establishes association of acetyl a-tubulin with asthenozoospermia, suggests the isoforms determining the acetylation, and provides insight into potential mechanism of transcriptional regulation of a-tubulin isoforms.
Polymorphisms in folate metabolizing genes and risk of idiopathic male infertility a study on a Russian population and a meta analysis
Polymorphisms in the folate-metabolizing genes could be associated with the risk of male infertility, but further studies having more statistical power are needed to investigate the association.
MicroRNA expression profiles in human testicular tissues of infertile men with different histopathologic patterns
Microarray and real-time polymerase chain reaction studies reveal that microRNAs are differentially expressed in normal versus different testicular histopathologic patterns and have therapeutic potential for the development of biomarkers for male infertility.
Dendritic cells in semen of infertile men Association with sperm quality and inflammatory status of the epididymis
The inflammatory status of the epididymis may be reflected by the abundance and activation status of dendritic cells in semen, which may affect sperm quality and fertility outcome.
Testosterone use in the male infertility population prescribing patterns and effects on semen and hormonal parameters
In Canada, testosterone is not commonly used by men presenting for fertility investigation (1.3%). Testosterone cessation generally resulted in an increase in sperm counts. A subset of men remained azoospermic.
Diagnostic accuracy of sperm chromatin dispersion test to evaluate sperm deoxyribonucleic acid damage in men with unexplained infertility
Sperm chromatin dispersion (SCD) and TUNEL are poorly correlated for estimating DNA damage in men with unexplained infertility. SCD discriminates normal and abnormal sperm DNA damage with up to 69% accuracy when compared with TUNEL.
Cigarette smoking is associated with abnormal histone to protamine transition in human sperm
Cigarette smoking is associated with abnormalities in histone-to-protamine transition independent of semen quality, and interferes with the mRNA expression of protamines in human sperm and TM3 cell lines.
Ultrasound definition of polycystic ovarian morphology good news and bad news
Reflections on “Follicle number, not assessments of the ovarian stroma, represents the best ultrasonographic marker of polycystic ovary syndrome” by Christ et al.
Economics of assisted reproductive technology data from an international analysis
Reflections on “The impact of consumer affordability on access to assisted reproductive technologies and embryo transfer practices: an international analysis” by Chambers et al.
Endometriosis the elusive gray area between evidence based and evidence biased medicine
Reflections on “An overview of the current status of clinical trials on endometriosis: issues and concerns” by Guo et al.