Tacrolimus has protective effects against uterine ischemia-reperfusion injury induced by distal abdominal aortic occlusion, and these cytoprotective effects may be due to its antioxidant and antiinflammatory properties.
Fibrin formulations with low concentrations of fibrinogen and thrombin can potentially be used as an artificial ovary, allowing follicle survival and development, cell proliferation, and formation of capillaries.
Twenty-five percent of morbidly obese girls were affected with PCOS, and 33% had metabolic syndrome; PCOS and its individual components did not predict metabolic syndrome in morbidly obese adolescents.
Extraction chromatography–radioimmunoassay and liquid chromatography–tandem mass spectrometry measurements of testosterone have similar performance for differentiating polycystic ovary syndrome from controls; different cutoff values should be considered depending on the setting (e.g., clinical vs. general populations).
Androgenic alopecia is prevalent in polycystic ovary syndrome (PCOS) and is associated with other manifestations of clinical hyperandrogenism, but not with greater risk of biochemical or metabolic abnormalities than with PCOS alone.
Secondary analysis of the Women’s Isoflavone Soy Health trial demonstrates that as menopausal onset increases in healthy postmenopausal women, oophorectomy is associated with faster rates of bone loss and carotid artery intima-media thickening.
Among midlife women, acute increases in daily physical activity were associated with increased odds of reporting hot flashes lacking physiologic evidence, particularly among women with higher levels of negative affect.
Array-based DNA-methylation profiling identifies 471 CpGs as markers for idiopathic infertility in peripheral blood and suggests allele-specific DNA methylation of PIWIL1 and PIWIL2 genes to be associated with disturbed spermatogenesis.
Exploring the association between male infertility and idic (Yq) chromosome using cytogenetic techniques on blood and semen germ cells could help in genetic counseling and choosing the proper reproduction technique.
Array-comparative genomic hybridization is a robust higher resolution alternative to multiplex polymerase chain reaction for detection of chromosome Y microdeletions, increasing the diagnostic yield in male infertility.
A testicular cell culture system allows for efficient propagation of spermatogonial stem cells from a biopsy for fertility preservation and also eliminates contaminating malignant acute lymphoblastic leukemia cells.
Our data suggest that, overall, reproductive parameters in our study population of young college students from the northeastern United States are comparable to those of young European and Japanese men.
Compared with non–assisted reproductive technology (ART) population control subjects, ART mothers and their adult offspring (18–28 years old) reported increased hospitalizations and respiratory problems, but no differences in quality of life, body mass index, or educational achievements.
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