We established a novel NOD/SCID murine xenograft model for uterine leiomyoma that reproduced histologic characteristics, sex steroid–dependent growth, and specific gene expression profiles of the original leiomyoma tissue.
After xenotransplantation, human primordial follicles can be matured to metaphase II oocytes even without stimulation. Administering human gonadotropin and GnRH agonist does not enhance the developmental capacity of oocytes in xenografts.
Contrary to previous assumptions, multi-oocyte follicles (MOFs) are frequently observed in the pubertal ovary. Follicle fusion, associated with granulosa cell invasiveness, appears to be the major mechanism for MOF generation.
Substantial variability in follicular fluid high-density lipoprotein particle components exist between follicles among women undergoing IVF as well as between women by age, BMI, race, smoking, and infertility diagnosis.
Three-dimensional sonohysterography—a minimally invasive and relatively inexpensive method with substantial interrater/intrarater agreement coefficients for the postoperative evaluation of the uterine cavity—is as diagnostically accurate as hysteroscopy.
Using longitudinal data on menstrual cycle function, we evaluated urinary cytokines levels for assessment of reproductive function by considering detection, variation across the menstrual cycle, and correlations with hormones.
Study reporting extensive preclinical validation and accuracy assessment of next-generation sequencing (NGS)-based comprehensive aneuploidy screening on single cells. NGS has demonstrated a robust methodology, ready for clinical application in reproductive medicine.
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