May 2014

Evaluation of the efficacy of laparoscopic resection for the management of exogenous cesarean scar pregnancy

Laparoscopic resection of a cesarean scar pregnancy has the advantages of shorter procedure duration, less blood loss, a shorter hospital stay, and faster recovery.

Fertility and Sterility

May 01, 2014

May 2014

Human embryos secrete microRNAs into culture media a potential biomarker for implantation

Human blastocysts secrete microRNAs into culture media, and MicroRNAs may be a noninvasive marker for delivery after in vitro fertilization.

Fertility and Sterility

May 01, 2014

May 2014

Nonobese diabetic severecombined immunodeficient murine xenograft model for human uterine leiomyoma

We established a novel NOD/SCID murine xenograft model for uterine leiomyoma that reproduced histologic characteristics, sex steroid–dependent growth, and specific gene expression profiles of the original leiomyoma tissue.

Fertility and Sterility

May 01, 2014

May 2014

Does stimulation with human gonadotropins and gonadotropin-releasing hormone agonist enhance and accelerate the developmental capacity of oocytes in human ovarian tissue xenografted into severe combined immunodeficient mice

After xenotransplantation, human primordial follicles can be matured to metaphase II oocytes even without stimulation. Administering human gonadotropin and GnRH agonist does not enhance the developmental capacity of oocytes in xenografts.

Fertility and Sterility

May 01, 2014

May 2014

Generation of multioocyte follicles in the peripubertal rat ovary Link to the invasive capacity of granulosa cells

Contrary to previous assumptions, multi-oocyte follicles (MOFs) are frequently observed in the pubertal ovary. Follicle fusion, associated with granulosa cell invasiveness, appears to be the major mechanism for MOF generation.

Fertility and Sterility

May 01, 2014

May 2014

Stimulation of mitochondrial embryo metabolism by dichloroacetic acid in an aged mouse model improves embryo development and viability

Stimulation of mitochondria in embryos from older mice improved embryo viability and fetal weights and therefore may be a novel means of improving outcomes in an IVF setting.

Fertility and Sterility

May 01, 2014

May 2014

Characterization of a mechanism to inhibit ovarian follicle activation

Foxo3 is induced in cell and organ culture, and a mouse model, by 2-deoxyglucose (2-DG). In mice, 2-DG treatment results in reduced activation of primordial follicles.

Fertility and Sterility

May 01, 2014

May 2014

Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth

Small molecules that specifically inhibit the canonical WNT/b-catenin pathway attenuate growth and proliferation of human uterine leiomyoma cell primary cultures.

Fertility and Sterility

May 01, 2014

May 2014

Variability in the components of high density lipoprotein particles measured in human ovarian follicular fluid A cross sectional analysis

Substantial variability in follicular fluid high-density lipoprotein particle components exist between follicles among women undergoing IVF as well as between women by age, BMI, race, smoking, and infertility diagnosis.

Fertility and Sterility

May 01, 2014

May 2014

Complete phenotypic and metabolic profiles of a large consecutive cohort of untreated Korean women with polycystic ovary syndrome

Our well-defined cohort provided comprehensive estimates of the features of metabolic and phenotypic profiles related to polycystic ovary syndrome in Korean women.

Fertility and Sterility

May 01, 2014

May 2014

Family based analysis of adiponectin gene polymorphisms in Chinese Han polycystic ovary syndrome

Transmission disequilibrium test analysis confirms that single-nucleotide polymorphism rs1501299 in ADIPOQ is significantly associated with risk of polycystic ovary syndrome in the Chinese population.

Fertility and Sterility

May 01, 2014

May 2014

Dopamine receptor 2 activation inhibits ovarian vascular endothelial growth factor secretion in vitro implications for treatment of ovarian hyperstimulation syndrome with dopamine receptor 2 agonists

Dopamine receptor 2 agonists inhibit VEGF secretion in a dose-dependent fashion, which is directly dependent on the amount of D2 expressed by luteinized granulosa cells.

Fertility and Sterility

May 01, 2014

May 2014

Cluster analysis of cardiovascular and metabolic risk factors in women of reproductive age

Although polycystic ovary syndrome is associated with metabolic risk, obesity was the major determinant for cardiometabolic disturbances in reproductive-aged women.

Fertility and Sterility

May 01, 2014

May 2014

A retrospective cohort study to evaluate the impact of meaningful weight loss on fertility outcomes in an overweight population with infertility

Overweight patients with infertility who underwent weight loss counseling and achieved meaningful weight loss (10%) had improved live birth rates compared with those who did not.

Fertility and Sterility

May 01, 2014

May 2014

Diagnostic accuracy of three dimensional sonohysterography compared with office hysteroscopy and its interrater intrarater agreement in uterine cavity assessment after hysteroscopic metroplasty

Three-dimensional sonohysterography—a minimally invasive and relatively inexpensive method with substantial interrater/intrarater agreement coefficients for the postoperative evaluation of the uterine cavity—is as diagnostically accurate as hysteroscopy.

Fertility and Sterility

May 01, 2014

May 2014

Urinary cytokine and chemokine profiles across the menstrual cycle in healthy reproductive age women

Using longitudinal data on menstrual cycle function, we evaluated urinary cytokines levels for assessment of reproductive function by considering detection, variation across the menstrual cycle, and correlations with hormones.

Fertility and Sterility

May 01, 2014

May 2014

Development and validation of a next generation sequencing based protocol for 24 chromosome aneuploidy screening of embryos

Study reporting extensive preclinical validation and accuracy assessment of next-generation sequencing (NGS)-based comprehensive aneuploidy screening on single cells. NGS has demonstrated a robust methodology, ready for clinical application in reproductive medicine.

Fertility and Sterility

May 01, 2014

May 2014

Socioeconomic inequalities in placental vascular resistance A prospective cohort study

Women from low socioeconomic subgroups have higher placental resistance indices during the second and third trimester, which is mainly caused by smoking during pregnancy.

Fertility and Sterility

May 01, 2014

May 2014

Urinary bisphenol A phthalates and couple fecundity The LIFE Study

Select phthalates, but not bisphenol A, were associated with diminished couple fecundity as measured by a longer time to pregnancy in a longitudinally observed cohort recruited before conception.

Fertility and Sterility

May 01, 2014

May 2014

Increased expression of antimullerian hormone and its receptor in endometriosis

Endometrium and endometriotic lesions express high levels of antim€ullerian hormone and its receptor, without any contribution to circulatory levels.

Fertility and Sterility

May 01, 2014

May 2014

Miscarriage chromosome testing Utility of comparative genomic hybridization with reflex microsatellite analysis in preserved miscarriage tissue

This observational study shows that comparative genomic hybridization and reflex microsatellite analysis are effective DNA technologies to determine chromosome results of preserved miscarriage tissue.

Fertility and Sterility

May 01, 2014

May 2014

Perinatal outcome of twin pregnancies after early transvaginal multifetal pregnancy reduction

The perinatal outcome of twin pregnancies after early transvaginal fetal reduction from triplets is equivalent to the outcome of nonreduced twin pregnancies.

Fertility and Sterility

May 01, 2014

May 2014

Concurrent estrogen action was essential for maximal progestin effect in oral contraceptives

Concurrent estrogen action enhances the progestin-induced growth inhibition of ovarian endometrioma epithelial cells via up-regulation of progestin receptor B expression in oral contraceptives.

Fertility and Sterility

May 01, 2014

May 2014

Pregnancy outcomes decline in recipients over age 44 An analysis of 27959 fresh donor oocyte in vitro fertilization cycles from the Society for Assisted Reproductive Technology

Based on recent U.S. summary data, donor oocyte recipients have stable rates of pregnancy outcomes before age 45, after which there is a small but steady and significant decline.

Fertility and Sterility

May 01, 2014

May 2014

Effect of oocyte donation on pregnancy outcomes in in vitro fertilization twin gestations

In patients who conceive twin pregnancies using IVF, oocyte donation increases the risk of gestational hypertension and preeclampsia.

Fertility and Sterility

May 01, 2014

May 2014

Effects of assisted reproductive technologies on human sex ratio at birth

The authors analyzed the gender of more than 100,000 babies in the United Kingdom born after ART and found that the type of ART treatment used can affect the sex ratio.

Fertility and Sterility

May 01, 2014

May 2014

Calculating length of gestation from the Society for Assisted Reproductive Technology Clinic Outcome Reporting System SART CORS database versus vital records may alter reported rates of prematurity

Methods for calculating gestational age in assisted reproductive technology and spontaneous deliveries can differ. Estimates of preterm birth rates can be influenced by these differences.

Fertility and Sterility

May 01, 2014

May 2014

A novel delayed start protocol with gonadotropin releasing hormone antagonist improves outcomes in poor responders

The delayed-start protocol improves ovarian response in poor responders by enhancing, promoting, and synchronizing follicle development.

Fertility and Sterility

May 01, 2014

May 2014

Cervical mucus removal prior to embryo transfer in women undergoing in vitro fertilization intracytoplasmic sperm injection A systematic review and meta analysis of randomized controlled trials

There is very little evidence of an overall benefit of cervical mucus removal before embryo transfer for women undergoing in vitro fertilization/intracytoplasmic sperm injection.

Fertility and Sterility

May 01, 2014

May 2014

Single embryo transfer of vitrified warmed blastocysts yields equivalent live birth rates and improved neonatal outcomes compared with fresh transfers

After 1,157 fresh and 645 vitrified-warmed day-5 single-blastocyst transfers, we found vitrified warmed blastocysts yielded equivalent birth rates and improved neonatal outcomes compared with fresh transfers.

Fertility and Sterility

May 01, 2014

May 2014

Effect of preovulatory progesterone elevation and duration of progesterone elevation on the pregnancy rate of frozen thawed embryo transfer in natural cycles

Prolonged exposure to preovulatory P elevation in frozen–thawed embryo transfer cycles in natural cycles adversely affected the pregnancy rates, similar to the fresh stimulated IVF treatment cycles.

Fertility and Sterility

May 01, 2014

May 2014

Dairy intake and semen quality among men attending a fertility clinic

Among men attending a fertility clinic, low-fat dairy intake, particularly low-fat milk, was related to higher sperm concentration and progressive motility, whereas cheese intake was related to lower sperm concentration.

Fertility and Sterility

May 01, 2014

May 2014

Anabolic steroid induced hypogonadism Diagnosis and treatment

A profile of the user with anabolic steroid–induced hypogonadism is provided, and management strategies are proposed.

Fertility and Sterility

May 01, 2014

May 2014

Simple circumcision device Proof of concept for a single visit adjustable device to facilitate safe adult male circumcision

A pilot trial of a novel circumcision device to facilitate safe, single-visit surgical circumcision in five patients from the Veterans Administration Puget Sound Healthcare System.

Fertility and Sterility

May 01, 2014

May 2014

Operating characteristics of follicle-stimulating hormone in azoospermic men

In a retrospective cohort study of azoospermic patients, the full operating characteristics of follicle stimulating hormone were determined to allow for proper education of patients and individualized treatment based on specific risk.

Fertility and Sterility

May 01, 2014

May 2014

Association of cystic fibrosis transmembrane-conductance regulator gene mutation with negative outcome of intracytoplasmic sperm injection pregnancy in cases of congenital bilateral absence of vas deferens

Cystic fibrosis transmembrane-conductance regulator mutations were observed to have higher prevalence in men with congenital bilateral absence of vas deferens and were associated with increased risk of miscarriage and stillbirth.

Fertility and Sterility

May 01, 2014

May 2014

An engaging example of translational medicine The Wnt β catenin cellular pathway and pharmacological research in fibroid treatment

Reflections on “Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth” by Ono et al.

Fertility and Sterility

May 01, 2014

May 2014

Next generation sequencing Challenges in reproductive genetics

Reflections on “Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos” by Yeh et al.

Fertility and Sterility

May 01, 2014

May 2014

Next generation sequencing The dawn of a new era for preimplantation genetic diagnostics

Reflections on “Development and validation of a next-generation sequencing–based protocol for 24-chromosome aneuploidy screening of embryos” by Fiorentino et al.

Fertility and Sterility

May 01, 2014

May 2014

Does the age of the recipient influence the probability of pregnancy along recipients of oocyte donation

Reflections on “Pregnancy outcomes decline in recipients over age 44: an analysis of 27,959 fresh donor oocyte in vitro fertilization cycles from the Society for Assisted Reproductive Technology” by Yeh et al.

Fertility and Sterility

May 01, 2014