June 2014

Hematoureter due to endometriosis

This video illustrates the intra-operative identification and laparoscopic management of ureteral endometriosis in a 17-year-old female with uterine didelphys, history of left nephrectomy, and partial ureter resection.

Fertility and Sterility

Jun 01, 2014

June 2014

Requirement of heart and neural crest derivatives expressed transcript 2 during decidualization of human endometrial stromal cells in vitro

Progestin-induced heart and neural crest derivatives–expressed transcript 2 plays a key role in the regulation of human decidualization.

Fertility and Sterility

Jun 01, 2014

June 2014

Differences in ovarian hormones in relation to parity and time since last birth

Among cycling women, parous women have longer follicular phases and lower estradiol metabolite concentrations than nulliparous women. Estradiol, but not progesterone, metabolite concentrations are positively associated with time since last birth.

Fertility and Sterility

Jun 01, 2014

June 2014

Comparability of antimullerian hormone levels among commercially available immunoassays

Measurement of antimullerian hormone (AMH) levels with a highly sensitive ELISA kit maximized detection at very low levels; conversion of AMH levels between different immunoassays is potentially highly inaccurate.

Fertility and Sterility

Jun 01, 2014

June 2014

Influence of oral contraceptives on anthropomorphometric endocrine and metabolic profiles of anovulatory polycystic ovary syndrome patients

Oral contraceptive pill use is associated with a higher risk of future endometriosis diagnosis in nulliparous women but a lower risk among parous women.

Fertility and Sterility

Jun 01, 2014

June 2014

Ovarian morphology assessed by magnetic resonance imaging in women with and without polycystic ovary syndrome and associations to anti Müllerian hormone free testosterone and glucose disposal rate

Magnetic resonance imaging yielded higher antral follicle counts (AFC) than previously reported. AFC, antimullerian hormone, and free testosterone discriminated with high accuracy between women with polycystic ovary syndrome and controls.

Fertility and Sterility

Jun 01, 2014

June 2014

High dose vitamin D supplementation and measures of insulin sensitivity in polycystic ovary syndrome A randomized controlled pilot trial

In a randomized, placebo-controlled trial of vitamin D in PCOS, insulin sensitivity was unchanged, but there was a trend toward decreased 2-hour insulin and a protective effect on blood pressure.

Fertility and Sterility

Jun 01, 2014

June 2014

Metabolic profile of the different phenotypes of polycystic ovary syndrome in two Latin American populations

The phenotype distribution and metabolic characteristics of polycystic ovary syndrome differ in Chile and Argentina; the former is more metabolically altered and the latter more hypertensive.

Fertility and Sterility

Jun 01, 2014

June 2014

Prospective assessment of midsecretory endometrial leukemia inhibitor factor expression versus ανβ3 testing in women with unexplained infertility

Epithelial LIF expression is reduced in the endometrium of women with UI and is superior to avb3 integrin alone for assessment of endometrial receptivity.

Fertility and Sterility

Jun 01, 2014

June 2014

X chromosome inactivation in female newborns conceived by assisted reproductive technologies

X-chromosome inactivation in female newborns is not affected by intracytoplasmic sperm injection or in vitro fertilization.

Fertility and Sterility

Jun 01, 2014

June 2014

Genetic variants in Ser Arg protein coding genes are associated with the risk of non obstructive azoospermia in Chinese men

A case-control study with 962 nonobstructive azoospermia (NOA) patients and 1,931 male control subjects revealed that single-nucleotide polymorphisms rs12046213 of SFRS4, rs6103330 near SFRS6, and rs17431717 near SFRS9 were significantly associated with NOA risk.

Fertility and Sterility

Jun 01, 2014

June 2014

Use of fertility treatment modalities in a large United States cohort of professional women

Approximately 94% of women using fertility treatment used clomiphene, with smaller proportions using gonadotropin alone, intrauterine insemination, and in vitro fertilization. These patterns varied by financial, biologic, and temporal factors.

Fertility and Sterility

Jun 01, 2014

June 2014

The influence of prior oral contraceptive use on risk of endometriosis is conditional on parity

Oral contraceptive pill use is associated with a higher risk of future endometriosis diagnosis in nulliparous women but a lower risk among parous women.

Fertility and Sterility

Jun 01, 2014

June 2014

The WNT β-catenin signaling pathway and expression of survival promoting genes in luteinized granulosa cells Endometriosis as a paradigm for a dysregulated apoptosis pathway

The WNT/b-catenin signaling pathway in luteinized granulosa cells from patients with endometriosis was altered, affecting survival-related gene expression involved in granulosa cell apoptosis eventually leading to increased follicular atresia.

Fertility and Sterility

Jun 01, 2014

June 2014

Elevated expression of CD147 in patients with endometriosis and its role in regulating apoptosis and migration of human endometrial cells

Highly expressed CD147 in ovarian endometriosis lesions with enhanced cell survival and migration in human endometrial cells may contribute to the progression of endometriosis.

Fertility and Sterility

Jun 01, 2014

June 2014

Recurrent miscarriages innate immunity and autoimmune reaction to chlamydial 60kDa heat shock protein Is there an association

Immunity to chlamydial heat shock protein (Chlam HSP60) and to human HSP60 is not significantly associated with a history of recurrent miscarriages or clinically relevant determinants of pregnancy loss.

Fertility and Sterility

Jun 01, 2014

June 2014

Human chorionic gonadotropin discriminatory zone in ectopic pregnancy Does assay harmonization matter

Despite significant differences in human chorionic gonadotropin (hCG) concentrations across hCG immunoassays, an hCG discriminatory zone of 1,500–3,500 IU/L can be used for all but one commonly used hCG reagent platform.

Fertility and Sterility

Jun 01, 2014

June 2014

Risk factors for early miscarriage among Chinese: a hospital-based case-control study

In a case-control study of early miscarriage among Chinese women, previous induced abortion, working night shifts, and frequently staying up late are associated risk factors.

Fertility and Sterility

Jun 01, 2014

June 2014

Pharmacokinetics of two low dose levonorgestrel releasing intrauterine systems and effects on ovulation rate and cervical function Pooled analyses of Phase II and III studies

In pooled analyses, LNG-IUS 13.5 mg and LNGIUS 19.5 mg result in lower LNG systemic exposure, lower incidence of anovulation, and a similar progestin impact on the endometrium and cervical function compared with LNG-IUS 20 mg/24 h.

Fertility and Sterility

Jun 01, 2014

June 2014

Patient specific predictions of outcome following gonadotropin ovulation induction intrauterine insemination

Using patient-specific and cycle-specific characteristics, we can predict the clinical pregnancy, multiple pregnancy, and miscarriage rates for individuals undergoing gonadotropin OI/IUI.

Fertility and Sterility

Jun 01, 2014

June 2014

Atypical embryo phenotypes identified by time lapse microscopy High prevalence and association with embryo development

Time-lapse microscopy is used to identify and define atypical human embryo phenotypes that may aid in the deselection of poorer quality embryos, thereby improving in vitro embryo selection.

Fertility and Sterility

Jun 01, 2014

June 2014

Precision of progesterone measures with the use of automated immunoassay analyzers and the impact on clinical decisions for in vitro fertilization

Progesterone measurements by direct immunoassay can be imprecise, affectingmedical decisions during IVF. A validated progesterone standard used in daily immunoassays could attenuate errors in assay imprecision.

Fertility and Sterility

Jun 01, 2014

June 2014

Is the modified natural in vitro fertilization cycle justified in patients with genuine poor response to controlled ovarian hyperstimulation

Modified natural cycles is of no benefit for “genuine” poor ovarian responders and the option of egg donation should be seriously considered for this population.

Fertility and Sterility

Jun 01, 2014

June 2014

Clinical success of intrauterine insemination cycles is affected by the sperm preparation time

The observance of a defined time interval from the end of sperm preparation to intrauterine insemination may improve pregnancy rates even if the couple’s parameters are not favorable.

Fertility and Sterility

Jun 01, 2014

June 2014

Acute epididymitis induces alterations in sperm protein composition

A single episode of acute epididymitis is associated with significant alterations in sperm protein composition, with several molecules known to be involved in sperm maturation, function, and fertility.

Fertility and Sterility

Jun 01, 2014

June 2014

Electroejaculation in psychogenic anejaculation

Electroejaculation is a suitable and effective treatment that can be used in men with psychogenic anejaculation. The retrieved semen can be used successfully in ART treatment.

Fertility and Sterility

Jun 01, 2014

June 2014

Seminal hyperviscosity is not associated with semenogelin degradation or sperm deoxyribonucleic acid damage A prospective study of infertile couples

Data from this study suggest that seminal hyperviscosity (a posttesticular factor) is not an important cause of sperm DNA damage and is not associated with semenoglin degradation.

Fertility and Sterility

Jun 01, 2014

June 2014

Hormone abnormalities are not related to the erectile dysfunction and decreased libido found in many men with infertility

Reduced libido and erectile dysfunction are common in young, infertile men. Using multivariable logistic analysis of a large cohort, our data suggest that this is unrelated to hormone changes.

Fertility and Sterility

Jun 01, 2014

June 2014

Sperm deoxyribonucleic acid damage in normozoospermic men is related to age and sperm progressive motility

We identified significant relationships between sperm DNA fragmentation and both paternal age and progressive motility in a large cohort of normozoospermic men presenting for infertility evaluation.

Fertility and Sterility

Jun 01, 2014

June 2014

Insights on managing the older couple with unexplained infertility and normal ovarian reserve

Reflections on “A randomized clinical trial to determine optimal infertility treatment in older couples: the forty and over treatment trial (FORT-T)” by Goldman et al.

Fertility and Sterility

Jun 01, 2014

June 2014

Sperm proteomics Fertility diagnostic testing beyond the semen analysis

Reflections on “Acute epididymitis induces alterations in sperm protein composition” by Pilatz et al.

Fertility and Sterility

Jun 01, 2014

June 2014

Relationship between testosterone and sexual function in infertile men

Reflections on “Hormone abnormalities are not related to the erectile dysfunction and decreased libido found in many men with infertility” by Satkunasivam et al.

Fertility and Sterility

Jun 01, 2014

June 2014

International Federation of Fertility Societies Surveillance 2013 preface and conclusions

Surveillance is a triennial worldwide compendium of national rules and regulations for assisted reproductive technology. It was last published in 2010.

Fertility and Sterility

Jun 01, 2014

June 2014

A randomized clinical trial to determine optimal infertility treatment in older couples The forty and over treatment trial

In older infertile women, treatment initiated with two cycles of CC/IUI or FSH/IUI compared with immediate IVF demonstrated superior pregnancy rates with fewer treatment cycles in the immediate IVF group.

Fertility and Sterility

Jun 01, 2014

June 2014

Long term treatment of uterine fibroids with ulipristal acetate

Repeated 3-month courses of ulipristal acetate control bleeding and pain, reduce fibroid volume, and restore quality of life over the long term in patients with fibroids.

Fertility and Sterility

Jun 01, 2014

June 2014

We need a prospective varicocelectomy trial

Controversy exists whether varicocelectomy improves pregnancy rates in couples with male infertility.

Fertility and Sterility

Jun 01, 2014

June 2014

MicroRNAs and spermatogenesis

This review article summarizes expression and functions of miRNAs during spermatogenesis and their importance in maintaining male fertility, and as potential biomarkers for male factor infertility.

Fertility and Sterility

Jun 01, 2014

June 2014

MicroRNAs and gynecological reproductive diseases

This review covers not only impact of microRNA dysregulation in the origin of gynecological disease, but also the potential diagnostic and therapeutic role that microRNA may play in gynecological pathologies.

Fertility and Sterility

Jun 01, 2014

June 2014

MicroRNAs and implantation

This review discusses diagnostic and therapeutic roles of miRNA in implantation. Although promising, further research is needed before miRNA are used in clinical practice for identifying and treating implantation failure.

Fertility and Sterility

Jun 01, 2014

June 2014

Regulatory role of microRNAs in ovarian function

MicroRNAs have a fundamental role in the regulation of gene expression in the ovary. Research on the role in physiological and dysfunctional ovulation may offer new diagnostic and therapeutic strategies.

Fertility and Sterility

Jun 01, 2014