Women with endometriosis undergoing assisted reproductive technology have increased nitrate and peroxynitrite in the oocyte microenvironment concurrent with adverse impact on maturation and aging of immature oocytes.
Fetal cells retrieved by endocervical cytobrush at 5–20 weeks of pregnancy and isolated with immunomagnetic nanoparticles are extravillous trophoblast cells that contain intact fetal DNA useful for prenatal testing.
This retrospective assessment of long-term effects of combined oral contraceptives (COCs) on relapsing–remitting multiple sclerosis showed that COC use is associated with reduced disability progression and reduced evolution to secondary-progressive multiple sclerosis.
No significant improvement in ovarian response markers, ovarian response to standard dose gonadotropin stimulation, or IVF outcomes was detected in poor responders receiving pretreatment DHEA compared with placebo.
In 14,328 oocyte cryopreservation procedures and 1,850 pregnancies reported to the National Italian Registry from 2007 to 2011, vitrification shows a higher pregnancy rate per started cycle than slow freezing.
In vitro fertilization increases MZT incidence; young oocytes, year of IVF cycle, and extended culture (embryo stage) confer the greatest risk. Specific assisted reproductive technology procedures may also contribute, although their impact correlates more with chorionicity.
In a comparison of the regular long protocol with a prolonged protocol with 28-days’ down-regulation, a significantly higher live-birth rate (55.56% vs. 45.73%) was observed with the prolonged protocol.
Deficient expression of SAM68 might be one of the factors involved in the mechanism underlying spermatogenic defects. These results may offer new perspectives on the molecular basis of abnormal spermatogenesis.
The urinary metabolome could differentiate oligozoospermic infertile men from fertile men. The disrupted metabolic pathways reflected fertility reduction that may be tightly associated with energy consumption and antioxidant defenses in spermatogenesis.
Each year nearly one in eight infants in the United States is born preterm. Preterm birth places babies at increased risk for death, health problems including long-term neurological disabilities, and extended time in the hospital.
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