Interleukin 1β 511T C genetic variant contributes to recurrent pregnancy loss risk and peripheral natural killer cell proportion

IL-1b -511CC genotype was associated with increased recurrent pregnancy loss risk and peripheral natural killer cell proportion.

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Authors

Nam Keun Kim, Ph.D., Jung O. Kim, M.S., Woo Sik Lee, M.D., Ph.D., Bo Eun Lee, M.S., Young Joo Jeon, M.S., Young Ran Kim, M.D., Ph.D., Sang Hee Jung, M.D., Sung Woon Chang, M.D., Ph.D.

Volume 102, Issue 1, Pages 206–212.e5

Abstract

Objective:

To identify whether interleukin gene polymorphisms are risk factors for idiopathic recurrent pregnancy loss (RPL) in Korean women.

Design:

Case–control study.

Setting:

Hospital-based study.

Patient(s):

A cohort of 385 idiopathic RPL patients and 232 controls with Korean ethnicity.

Intervention(s):

None.

Main Outcome Measure(s):

Genotyping was assessed with a polymerase chain reaction–restriction fragment length polymorphism assay. We examined polymorphisms in three interleukin (IL) genes: IL-1β, IL-4, and IL-10.

Result(s):

The IL-1β -511T>C polymorphism was associated with RPL (-511TT vs. -511CC: adjusted odds ratio 1.826; 95% confidence interval 1.130–2.953). Allelic gene–gene interaction analysis revealed that the T/B2/G (IL-1β/IL-4/IL-10) allele combination was only detected in the RPL group (adjusted odds ratio 20.046; 95% confidence interval 1.188–338.204). The proportion of peripheral natural killer cells was higher in patients with the IL-1β -511C allele compared with the -511T allele.

Conclusion(s):

According to these results, IL-1β -511T>C may be a predisposing factor to RPL susceptibility. However, the mechanism underlying the function of IL-1β -511T>C in RPL remains to be determined, and further studies are needed to improve understanding of the roles of IL-1β -511T>C, using a larger and more heterogeneous cohort.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)00292-1/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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