In this Conceptions piece, we set out to explore whether current scientific evidence supports the future use of a GnRH-a trigger in all IVF patients co-treated with a GnRH antagonist, regardless of ovarian response on the day of trigger. The studies examined, our own and those of others, provide evidence that this is a helpful approach.
We describe the potential use of optical filters that block light wavelengths below 480 nm as an effective method to prevent acute disruption in circadian rhythm phase markers, including suppression of melatonin by light exposure at night.
Melatonin receptor expression is upregulated in the pregnant human myometrium at the time of labor, leading to synergism with oxytocin signaling to promote high uterine contractility and parturition at night.
Both circadian rhythms and melatonin are important for optimal function of the peripheral reproductive system. In addition to synchronizing rhythms, melatonin may protect the ovary, especially the oocyte and the placenta, from oxidative damage.
The three articles in this month’s “Views and Reviews” section discuss the impact of circadian rhythms, especially the nocturnal secretion of melatonin, on reproductive function and parturition in the human.
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