September 2014

All the papers from the September 2014 issue of Fertility and Sterility.

Impact of lymphoma treatments on spermatogenesis and sperm deoxyribonucleic acid A multicenter prospective study from the CECOS network

Lymphoma treatments had highly damaging effects on spermatogenesis and sperm chromatin quality. Mean pretreatment sperm concentrations were recovered at 12months after doxorubicin, bleomycin, vinblastine, darcarbacine (ABVD) or ABVD + radiotherapy, but at 24 months after doxorubicin, cyclophosphamide, vincristine, prednisone(CHOP) ormechlorethamine, oncovin, procarbazine, prednisone (MOPP) therapies.

Advocating for longitudinal follow up of the health and welfare of egg donors

Egg donation continues to increase in popularity as part of assisted reproduction. Although short-term health effects of donation have been well studied, many unanswered questions remain about the long-term medical and psychological consequences for women who donate eggs. Studies of longer-term postdonation health effects have significant limitations, and are often retrospective, cross-sectional, or case studies.

Comprehensive chromosome screening with synchronous blastocyst transfer Time for a paradigm shift

Recently, the nature of assisted reproductive technology (ART) laboratory investigation has been shifting. Traditionally, it has focused on optimizing the culture milieu or assuring fertilization; now, a variety of new technologies are available to assess the reproductive potential of individual embryos. Perhaps most prominent has been the resurgence of embryonic aneuploidy screening. The validation of 24-chromosome testing platforms has led to a variety of studies demonstrating higher implantation and delivery rates.

The practice of in vitro fertilization according to the published literature

The “holy grail” of in vitro fertilization is identifying a single embryo that produces a healthy baby. Currently, we have the ability to select a single euploid embryo for transfer. This can be achieved without harming the embryo if the biopsy is done at the blastocyst stage. Blastocysts can be frozen with high survival rates and then transferred in a thaw cycle. The implantation of frozen thawed embryos has been shown to be superior to those transferred into an endometrium that is under the influence of the stimulated environment.