Ovaries of mouse offspring from high–fat–fed obese dams have reduced follicular population and altered gene expression, which could impact their reproductive potential.

Recombinant pigment epithelium–derived factor can protect granulosa cell viability in oxidative stress conditions by increasing SOD-1 and GPX- 2 mRNA levels, decreasing the protein level of BAX, and inducing AKT phosphorylation.

Treating oocyte-conditioned media with proteases and hexane provided evidence for the oocyte derived chemoattractant being a hydrophobic nonpeptide molecule that, in an oocyte-conditioned medium, is associated with a carrier protein.

Experimental study was designed to investigate the effect of enoxaparin treatment combination with ovarian detorsion on ovarian reserve and we found this therapy is more effective than detorsion alone treatment.

Antiapoptotic drug sphingosine-1-phosphate suppresses follicular depletion associated with chemotherapeutic agent cyclophosphamide treatment in human fetal ovarian xenografts, potentially providing a new option to prevent infertility associated with cancer treatments.

This study describes a novel dynamic culture system supporting initiation of physiologic follicular growth in 8-day-old murine ovaries. Dynamic culture seems to be promising within the context of fertility preservation.

Myeloid ecotropic viral integration site 1 (MEIS1) was expressed in response to sex steroid in the endometrium both in vitro and in vivo. Diminished endometrium MEIS1 expression may contribute to implantation failure in endometriosis.

AMH and FOXL2 collaboratively work to reserve ovarian follicles.

GnRH receptor analysis showed deleterious mutations in 10% of normosmic isolated hypogonadotropic hypogonadism patients, with a good genotype-phenotype correlation. No significant alterations were identified in constitutional delay of growth and puberty.

GnRH receptor analysis showed deleterious mutations in 10% of normosmic isolated hypogonadotropic hypogonadism patients, with a good genotype-phenotype correlation. No significant alterations were identified in constitutional delay of growth and puberty.

Normal weight adolescents with PCOS and a maternal history of PCOS had a significantly increased rate of insulin resistance independent of body mass index and inversely correlated with high molecular weight adiponectin.

Hysterosalpingo-foam sonography (HyFoSy) is a less painful office procedure for tubal patency testing during the fertility work-up compared to hysterosalpingography.

Because deletions of DMRT1 are found in XY gonadal dysgenesis, ovotesticular disorder, and male infertility, we sequenced DMRT1 in 171 male infertility patients and detected four possibly pathogenic mutations.

Resumption of menses 1 year or more after treatment is similar among women with breast cancer who receive a gonadotropin-releasing hormone agonist with chemotherapy or chemotherapy alone.

This retrospective cohort study demonstrates the advantage of younger age for substantial benefits from uterus-sparing surgery in women with adenomyosis-associated subfertility.

Assisted hatching use has increased but is not associated with improved pregnancy outcomes, even in poor prognosis patients. Prospective studies should better assess the potential benefits of assisted hatching.

Of 94 women with Herlyn-Werner-Wunderlich syndrome who were retrospectively analyzed and followed, nearly one-fifth were susceptible to pelvic endometriosis.

Elevated levels of serum sRAGE were associated with recurrent pregnancy losses. sRAGE level was correlated with insulin, PAI-1, uterine radial artery resistance index, and TNF-a/IL-10 producing T helper cell ratios.

Antimullerian hormone (AMH) and antral follicle count (AFC) are significantly lower among women with recent exposure to hormonal contraception. AMH and AFC should be interpreted cautiously when measured in the setting of recent hormone use.

Prior data suggested that tubal temperatures are lower than the IVF culture temperature of 37C. Paired comparison of human embryo culture at 36C and 37C reveals better outcomes at 37C.