December 2014

All the papers from the December 2014 issue of Fertility and Sterility.

Immunomodulatory treatment with intravenous immunoglobulin and prednisone in patients with recurrent miscarriage and implantation failure after in vitro fertilization intracytoplasmic sperm injection

This retrospective cohort study presents the live birth rate in 52 patients with three or more previous pregnancy losses after assisted reproductive techniques who were treated with intravenous immunoglobulin and prednisone concurrent with in vitro fertilization/intracytoplasmic sperm injection.

Keeping clinicians in research The Clinical Research Reproductive Scientist Training Program CREST strategy 2006 2012

Combining clinical practice with clinical research has been, and continues to be, a major challenge (1). Although the need for translational and clinical research has increased, the resources and the percent of physicians with federal funding for research have diminished. In 1998, 36.1% of M.D.-only physicians who applied for National Institutes of Health (NIH) grants were awarded funding, compared with 26.3% in 2011 (2). The competition for research grants is due partly to shrinking research dollars and partly to the increase in grant applications by Ph.D.s.

Mild approaches in assisted reproduction Better for the future

Current approaches for in vitro fertilization (IVF) in the majority of assisted conception units throughout the world are aggressive, unphysiological, and expensive. Is this really necessary? There is a widespread belief among practitioners that for a woman the only consideration is a high success rate, and that the current practice of down-regulation, high-dose stimulation, and retrieval of a large number of oocytes yields a higher success rate per cycle and better outcomes. Incidentally, it also results in a higher income for the clinic, so surely, the argument goes, this is a win-win situation for both patient and practitioner.