The role of chromothripsis, a heretofore unexpected cause of massive chromosomal rearrangements, and its potential impact on gametogenesis and early embryonic development are explored in this review.
All the papers from the December 2014 issue of Fertility and Sterility.
Unfolded protein response prevents blastocyst formation during preimplantation embryo development in vitro
Accumulation of unfolded proteins as a result of increased endoplasmic reticulum stress in the developing murine preimplantation embryo in vitro triggers apoptosis and negatively affects blastocyst formation.
Elevated non esterified fatty acid concentrations during in vitro murine follicle growth alter follicular physiology and reduce oocyte developmental competence
Long-term elevated NEFA concentrations, typical in metabolic disorders, such as obesity or type 2 diabetes, alter follicular growth and physiology, ultimately resulting in reduced oocyte developmental competence in vitro.
Timing of oviductal fluid collection steroid concentrations and sperm preservation method affect porcine in vitro fertilization efficiency
Changes in steroid concentrations during the reproductive cycle are delayed in oviductal fluid (OF) compared with serum. Oocyte incubation with pre- or postovulatory OF differentially affects in vitro fertilization efficiency.
Molecular characterization of exosomes and their microRNA cargo in human follicular fluid Bioinformatic analysis reveals that exosomal microRNAs control pathways involved in follicular maturation
Highly represented exosomal microRNAs in human follicular fluid control pathways that are essential for follicular maturation. Identified microRNAs may be very useful as noninvasive biomarkers of oocyte quality.
Antimullerian hormone regulates stem cell factor via the cyclic adenosine 30:50 monophosphate/protein kinase A (cAMP/PKA) pathway in human granulosa cells.
Ovarian morphology and function during growth hormone therapy of short girls born small for gestational age
We discuss how growth hormone treatment of girls born small for gestational age appeared to normalize ovarian morphology and function, while the long-term effects of growth hormone treatment on adult reproductive function remain unknown.
Women with blood type O had a reduced likelihood of diminished ovarian reserve, but women with blood type B or AB had an increased risk.
BRCA1 carriers have a decreased ovarian reserve, as evidenced by lower age- and body mass index–adjusted serum anti-Mullerian hormone levels, compared with women without BRCA mutations.
Marital stability and repartnering Infertility related stress trajectories of unsuccessful fertility treatment
Patients in fertility treatment who have ended relationships and repartnered have higher levels of infertility stress before and after separation compared with those who remain in the same relationship.
The presence of objective hot flashes accounts for a statistically significant proportion of the total amount of time spent awake after sleep onset, as defined by polysomnography in perimenopausal women.
During long-term culture, human spermatogonial stem cells maintain a stable chromosomal status but undergo some alterations in the methylation status of several parental imprinted genes.
DNA retrieved by blastocentesis provided a chromosome condition that was highly correspondent with that found in trophectoderm cells. Results from polar bodies and blastomeres were also predictive of the blastocyst’s ploidy.
Validation of multiple annealing and looping based amplification cycle sequencing for 24 chromosome aneuploidy screening of cleavage stage embryos
In the present study, we validated MALBAC sequencing for aneuploidy screening of the cleavage embryos and tested the high proportion of abnormal chromosomes.
This population-based study demonstrated a significantly increased risk of developing male infertility among HBV carriers (hazard ratio 1.52).
Ectopic pregnancy rates among Medicaid beneficiaries declined slightly in California, Illinois, and New York in 2000–2008, but African American women face consistently higher rates than whites across 14 diverse states.
Estimates of pregnancy intentions are highly sensitive to survey instruments.
Comparative study of ovarian clear cell carcinoma with and without endometriosis in Peoples Republic of China
Patients with endometriosis-associated ovarian clear cell carcinoma had distinct clinicopathological features and improved survival rates, although endometriosis was not an independent predictor of survival itself.
Immunomodulatory treatment with intravenous immunoglobulin and prednisone in patients with recurrent miscarriage and implantation failure after in vitro fertilization intracytoplasmic sperm injection
This retrospective cohort study presents the live birth rate in 52 patients with three or more previous pregnancy losses after assisted reproductive techniques who were treated with intravenous immunoglobulin and prednisone concurrent with in vitro fertilization/intracytoplasmic sperm injection.
Day-1 b-hCG should be used as a predictor for methotrexate treatment success, both in the first and the second injection of methotrexate.