Maternal undernutrition induces premature reproductive senescence in adult female rat offspring
An adverse uterine nutritional environment during pregnancy results in premature reproductive senescence in adult rats.
January 2015
All the papers from the January 2015 issue of Fertility and Sterility.
Simple perfusion apparatus for manipulation tracking and study of oocytes and embryos
A simple perfusion apparatus was designed, constructed, and tested for safely and securely culturing, testing, and visualizing oocytes and embryos for longitudinal analysis with minimal handling.
Granulocyte colony stimulating factor prevents loss of spermatogenesis after sterilizing busulfan chemotherapy
Spermatogenesis can be destroyed by alkylating chemotherapies. In this study, spermatogenesis and undifferentiated spermatogonia in mice treated with busulfan were protected by treatment with granulocyte colony-stimulating factor.
Use of gonadotropin releasing hormone agonist trigger during in vitro fertilization is associated with similar endocrine profiles and oocyte measures in women with and without polycystic ovary syndrome
Use of a gonadotropin-releasing hormone agonist trigger during in vitro fertilization results in similar hormone profiles, mature oocyte yield, and pregnancy outcomes in women with polycystic ovarian syndrome when compared with other high responders.
Preconceptional thyroid stimulating hormone levels and outcomes of intrauterine insemination among euthyroid infertile women
Among euthyroid patients undergoing IUI, TSH level was not associated with cycle parameters or clinical pregnancy rate. TSH level was inversely related to the odds of spontaneous abortion.
Intrafollicular cortisol levels inversely correlate with cumulus cell lipid content as a possible energy source during oocyte meiotic resumption in women undergoing ovarian stimulation for in vitro fertilization
We discuss how follicular fluid cortisol levels may regulate cumulus cell lipolysis during oocyte meiotic resumption and affect oocyte quality during in vitro fertilization.
Satisfaction with known open identity or unknown sperm donors Reports from lesbian mothers of 17 year old adolescents
A mixed-method study of 129 lesbian mothers found that most were satisfied with their choice 18 years previously of a known, open-identity, or unknown sperm donor.
Quality of reporting in infertility journals
Except for the most commonly cited fertility and gynecology journals, reporting guidelines are uncommonly requested from the authors. Also, accomplishment of CONSORT items was suboptimal in randomized controlled trials.
Leptin downregulates γ-ENaC expression: A novel mechanism involved in low endometrial receptivity
Polycystic ovary syndrome patients who are overweight or obese showed increased serum leptin levels. High leptin levels may reduce g-epithelial Naþ channel expression in human endometrium via activating the STAT3 pathway, resulting in attenuated endometrial receptivity.
Long term results of vaginal construction with the use of Frank dilation and a peritoneal graft Davydov procedure in patients with Mayer Rokitan Sky Kuster Syndrome
In the majority of patients with Mayer-Rokitansky-K€uster syndrome, a functional vagina could be created by Frank dilation and Davydov neovaginoplasty with the use of a peritoneal graft.
Copy number variation associated with meiotic arrest in idiopathic male infertility
In an assessment of the presence of copy number variations (CNV) in men presenting with meiosis arrest and azoospermia, we detected two unique CNVs and several in known meiosis genes.
Oocyte donation outcome after oncological treatment in cancer survivors
The reproductive outcomes of oocyte donation from women cured of cancer are similar to those from women without previous cancer, regardless of cancer type.
Uterus transplantation trial 1 year outcome
Nine women with uterine factor infertility underwent live-donor uterus transplantation. The seven cases with viable uteri after 12 months are presented, with special reference to menstruation, blood flow, rejection, and immunosuppression.
Dietary fatty acid intakes and asthenozoospermia A case control study
The high intake of saturated and trans-fats was positively related to asthenozoospermia. Dietary omega-3 polyunsaturated fatty acids are dose dependently and inversely associated with reduced odds of asthenozoospermia.
A prospective study of prepregnancy serum concentrations of perfluorochemicals and the risk of gestational diabetes
We observed in a prospective United States cohort study that higher environmentally relevant serum perfluorooctanoic acid concentrations before pregnancy were significantly associated with a greater risk of gestational diabetes.
Impact of assisted reproductive technology on the incidence of multiple gestation infants A population perspective
We discuss that in monitoring the safety and efficacy of fertility treatment, registration of the percentage of single embryo transfer cycles might not be sufficient and utilization should be taken into account as well.
Biomarkers of exposure to molybdenum and other metals in relation to testosterone among men from the United States National Health and Nutrition Examination Survey 2011 2012
Molybdenum and several other metals were associated with altered testosterone in men, which may have important implications as altered testosterone has been linked to many adverse health effects.
Healthcare utilization and costs in women diagnosed with endometriosis before and after diagnosis A longitudinal analysis of claims databases
Endometriosis is associated with a substantial economic burden during the 5-year periods both before and after diagnosis; healthcare utilization and costs peak during the first year after diagnosis among endometriosis patients.
Fetal endometriosis A case report
A fetal pelvic mass was diagnosed at 35 weeks’ gestation and removed on day of life 2, revealing endometriosis. This case provides some support for theories on the pathophysiology of neonatal endometriosis
Macrophage migration inhibitory factor as a potential biomarker of endometriosis
Overexpression of MIF, CD74, and COX-2 genes in ectopic endometrium and macrophage migration inhibitory factor protein in blood serum of endometriosis patients can be considered as a molecular biomarker for endometriosis development and pathophysiology.
Urinary tract endometriosis in patients with deep infiltrating endometriosis Prevalence symptoms management and proposal for a new clinical classification
Involvement of the urinary tract is frequent in patients with deep infiltrating endometriosis, and the probability of ureteral involvement is in linear correlation to the size of endometriotic rectovaginal nodules.
Expression of GRIM 19 in missed abortion and possible pathogenesis
Through a case-control study, the GRIM-19 deficiency in the villus was found may be associated with missed abortion via increasing apoptosis and affecting angiogenesis.
Timing of postpartum intrauterine device placement: a cost effectiveness analysis
We discuss a cost-effectiveness analysis demonstrating that immediate postpartum intrauterine device placement is a cost-effective method of contraception compared with routine placement and prevents unintended pregnancies.
Antimullerian hormone as predictor of implantation and clinical pregnancy after assisted conception: a systematic review and meta analysis
Antimullerian hormone has weak association with implantation and clinical pregnancy rates in women undergoing ART, but its predictive ability for pregnancy rates is greatest in women with diminished ovarian reserve.
Is polycystic ovarian morphology related to a poor oocyte quality after controlled ovarian hyperstimulation for intracytoplasmic sperm injection Results from a prospective comparative study
A comparison of controlled ovarian hyperstimulation outcomes between patients with polycystic ovarian morphology and concurrently treated and age-matched controls does not reveal any difference regarding oocyte quality.
Progesterone elevation on the day of human chorionic gonadotropin administration is not the only factor determining outcomes of in vitro fertilization
The elevated progesterone on the day of human chorionic gonadotropin triggering has an obvious negative impact on pregnancy outcome only at extremely high progesterone concentrations.
Calcium infusion for the prevention of ovarian hyperstimulation syndrome A double blind randomized controlled trial
Intravenous calcium infusion effectively reduced the incidence of ovarian hyperstimulation syndrome development without reduction in the pregnancy rate.
Blastocyst transfer is not associated with increased rates of monozygotic twins when controlling for embryo cohort quality
The association between blastocyst transfer and monozygotic twinning may be related to the high quality nature of the embryo cohort rather than the extended culture.
Assisted reproductive technology and breastfeeding outcomes A case control study
Women who give birth after experiencing infertility and undergoing assisted reproductive techniques are at higher risk for early breastfeeding cessation.
Low technology assisted reproduction and the risk of preterm birth in a hospital based cohort
In a hospital-based cohort, intrauterine insemination and/or ovulation induction/stimulation was associated with increased risk of preterm birth at <37, <35, and
Pregnancy outcomes in very advanced maternal age pregnancies The impact of assisted reproductive technology
Very advanced maternal aged women using ART are more likely to be primiparous or undergo elective cesarean delivery, and are at increased risk of retained placenta. Oocyte source does not affect outcomes.
Prolonging oocyte in vitro culture and handling time does not compensate for a shorter interval from human chorionic gonadotropin administration to oocyte pickup
Delaying oocyte denudation or injection does not compensate for a suboptimal in vivo exposure to the follicular environment.
Relationship between semen production and medical comorbidity
Men with medical comorbidities have a higher rate of abnormal semen parameters.
Analysis of semen parameters in male referrals: Impact of reference limits, stratification by fertility categories, predictors of change, and comparison of normal semen parameters in subfertile couples
Men with “normal” semen results are vastly underrepresented in the referral population. Men with any semen parameter below the World Health Organization 2010 criteria demonstrated findings indicative of a global dysfunction in spermatogenesis.
Status of sperm morphology assessment: An evaluation of methodology and clinical value
Morphology levels in sperm assessments decreased over time, owing to changes in methodological factors, and male aging. No prognostic value was found for individual in vitro fertilization or intracytoplasmic sperm injection patients.
Genomic and genetic variation in E2F transcription factor-1 in men with nonobstructive azoospermia
E2F1 gene dosage changes were identified in 7.3% of nonobstructive azoospermic men but rarely occur in the general population, suggesting a role for E2F1 in male fertility.
Urinary tract endometriosis A challenging disease
Reflections on “Urinary tract endometriosis in patients with deep infiltrating endometriosis: prevalence, symptoms, management and proposal for a new clinical classification” by Knabben et al.
Semen analysis parameters Stay calm they are just numbers
Reflections on “Analysis of semen parameters in male referrals: impact of reference limits, stratification by fertility categories, predictors of change, and comparison of normal semen parameters in subfertile couples,” by Baker et al.
Recommendations for practices utilizing gestational carriers: A committee opinion
This document provides the latest recommendations for the use of a gestational carrier, including indications for this technique and the evaluation of carriers and intended parents.
Surfing the waves of change in reproductive medicine: past, present and future. A presentation of the 2014 ASRM Strategic Plan
A presentation at the Opening Ceremony of the ASRM Seventieth Annual Meeting reviews advances in reproductive medicine and presents an overview of the 2014 Strategic Plan: “Global Impact Through Dynamic Engagement."