Each small antral follicle in ovaries of women with polycystic ovary syndrome produces more antimullerian hormone than its counterpart in a normal ovary An observational cross sectional study

An observational cross-sectional study showed that subfertile women with polycystic ovary syndrome secrete significantly more antimullerian hormone per antral follicle than women with polycystic ovarian morphology only and control women.

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Authors

Priya Bhide, M.R.C.O.G., Merve Dilgil, M.Sc., Anil Gudi, M.R.C.O.G., Amit Shah, M.R.C.O.G., Charity Akwaa, B.Sc., Roy Homburg, F.R.C.O.G.

Volume 103, Issue 2, Pages 537-541

Abstract

Objective:

To ascertain if subfertile women with polycystic ovary syndrome (PCOS) secrete more antimüllerian hormone (AMH) per antral follicle than control women.

Design:

Observational cross-sectional study.

Setting:

Fertility clinic.

Patient(s):

A total of 438 women attending the fertility clinic over a period of 13 months from September 2012 to September 2013.

Intervention(s):

Serum concentrations of AMH and the total antral follicle count (AFC) were obtained from women attending the fertility clinic. The ratio of AMH/AFC for each subject was calculated. Women were categorized into three groups: PCOS, polycystic ovarian morphology (PCOM), and control. PCOS and PCOM were defined based on the European Society for Human Reproduction and Embryology/American Society for Reproductive Medicine Rotterdam consensus criteria.

Main Outcome Measure(s):

The ratio of AMH/AFC for each subject in the three groups: PCOS, PCOM, and control.

Result(s):

The median AMH/AFC ratios in the PCOS, PCOM, and control groups were 1.92, 1.13, and 1.00, respectively. The AMH/AFC ratio was significantly higher in the PCOS group compared with the PCOM and control groups (F[2,152] = 21.82). Women in the three groups were not statistically different regarding age, body mass index, earlier ovarian surgery, and smoking status.

Conclusion(s):

Subfertile women with PCOS secrete significantly more AMH per antral follicle than women with PCOM only and control women.

Read the full text at: http://www.fertstert.org/article/S0015-0282(14)02293-6/fulltext


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Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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