Male factor infertility is the cause of infertility in 50% of infertile couples. This manuscript reviews the commonly used off-label medications used to treat idiopathic male factor infertility: clomiphene citrate, letrozole/anastrozole, exogenous androgens, and pentoxifylline.
Off-label drug use is common for treatment of reproductive disorders. Clinician awareness of US Food and Drug Administration indications for drug use is essential to proper communication with patients regarding the risk-benefit ratios of treatments.
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