Male factor infertility is the cause of infertility in 50% of infertile couples. This manuscript reviews the commonly used off-label medications used to treat idiopathic male factor infertility: clomiphene citrate, letrozole/anastrozole, exogenous androgens, and pentoxifylline.
Female infertility is often treated with both off-label medications and those approved by the US Food and Drug Administration. This review describes commonly used drugs for this indication.
Off-label drug use is common for treatment of reproductive disorders. Clinician awareness of US Food and Drug Administration indications for drug use is essential to proper communication with patients regarding the risk-benefit ratios of treatments.