The literature indicates that children conceived by assisted reproductive technology may be at increased risk of somatic morbidity in childhood compared with spontaneously conceived children.
Economic evaluation of elective single embryo transfer with subsequent single frozen embryo transfer in an in vitro fertilization intracytoplasmic sperm injection program
The choice of elective single-embryo transfer strategy to be adopted should be determined by the context of the health system and the individual prognosis.
In this study of blastomere number and aneuploidy, rapidly developing cleavage-stage embryos are more likely to progress to blastocysts and are more likely to be chromosomally abnormal.
Noninvasive embryo viability assessment by quantitation of human haptoglobin alpha 1 fragment in the in vitro fertilization culture medium An additional tool to increase success rate
The measurement of the haptoglobin a-1 fragment in human serum albumin–supplemented culture medium serves as an alternative to assess viability by the exclusion of embryos having low implantation potential.
In vitro development of donated frozen thawed human embryos in a prototype static microfluidic device A randomized controlled trial
This study shows that a microfluidic device tested under static conditions supports single-embryo culture of donated frozen-thawed human day-4 embryos to advanced blastocyst stages.
Ovulation rate and cycle characteristics in a subsequent clomiphene citrate cycle after stair step protocol
The ovulatory dose in the clomiphene citrate (CC) stair-step protocol is effective in inducing ovulation in most patients undergoing a subsequent CC cycle.
Progesterone to follicle index is better correlated with in vitro fertilization cycle outcome than blood progesterone level
The progesterone-to-follicle index has a linear and inverse relationship to cycle outcome, unlike blood progesterone, which is detrimental only at high levels.
Embryos derived from cryopreserved oocytes demonstrate impaired blastulation but equivalent rates of euploidy, implantation, and live birth compared with fresh oocytes, supporting the safety and efficacy of oocyte cryopreservation.
Frozen thawed day 5 blastocyst transfer is associated with a lower risk of ectopic pregnancy than day 3 transfer and fresh transfer
Frozen-thawed day 5 blastocyst transfer is associated with a lower ectopic pregnancy rate than frozen- thawed day 3 transfer and fresh transfer in patients undergoing IVF-ET.
A robust method for culturing caput, corpus, and cauda epithelial cells from primary human epididymis is established. These cells provide useful reagents for studying epididymis epithelial function.
Optimizing human semen cryopreservation by reducing test vial volume and repetitive test vial sampling
Optimal cryopreservation test vial volume is 100 mL; results from one test vial appear to be sufficiently predictive of post-thaw quality for multiple ejaculates frozen over 10 days.
Spontaneous pregnancy rates in Chinese men undergoing microsurgical subinguinal varicocelectomy and possible preoperative factors affecting the outcomes
Microsurgical varicocelectomy could improve semen quality and spontaneous pregnancy rates in patients with varicoceles. Patients with high initial sperm concentration may benefit from varicocelectomy.
Reflections on “Lapse in embryo transfer training does not negatively affect clinical pregnancy rates for reproductive endocrinology and infertility fellows” by Kresowick et al.
The purpose of this ASRM Practice Committee report is to provide clinicians with principles and strategies for the evaluation of couples with male infertility problems.
Currently there is no uniformly accepted definition of decreased ovarian reserve (DOR), as the term may refer to three related but distinctly different outcomes: oocyte quality, oocyte quantity, or reproductive potential. Available evidence concerning the performance of ovarian reserve tests is limited by small sample sizes, heterogeneity among study design, analyses and outcomes, and the lack of validated outcome measures.
“I’ve thought about this a lot, and I think I’m stuck” (Anonymous)
The use of “off-label” medications in the treatment of endometriosis is widespread. After an overview of Food and Drug Administration–approved treatments, this article reviews the use of “off-label” medications for endometriosis.
This review explores the off-label use of medications used to manage aspects of polycystic ovary syndrome, including androgen excess, irregular menses, and metabolic changes.