An examination of the surface proteome of prereceptive and receptive mouse luminal endometrium by two-dimensional liquid chromatography with tandem mass spectrometry found 45 proteins to be differentially expressed.
Administration of human chorionic gonadotropin induces granulosa cell expression of mRNA for the proteinases MMP1, MMP19, ADAMTS1, and ADAMTS9 in the dominant follicle collected across the periovulatory period of the menstrual cycle.
Benzo(a)pyrene disrupts mouse preimplantation embryo development by increasing reactive oxygen species level, inducing genomic and telomeric DNA damage and cell apoptosis, and reducing inner cell mass ratio.
Low birth weight may influence the appearance of hyperandrogenism and insulin resistance in some adolescents with polycystic ovary syndrome, but in the majority factors other than birth weight are implicated.
MiR-22-3p showed a lower expression level in 140 premature ovarian failure (POF) patients and was modestly effective in distinguishing POF from control subjects. It may be a consequence of the pathologic process of POF.
The presence of adrenal hyperandrogenism in women with polycystic ovary syndrome is associated with reduced insulin sensitivity and increased blood pressure, but may have a beneficial impact on the lipid profile.
Associations between ultrasound features and reproductive and metabolic markers in women with polycystic ovary syndrome (PCOS) were assessed. Follicle populations reflected the severity of reproductive and metabolic dysfunction in PCOS.
Risk factors for intrauterine adhesions include retained products of conception (RPOC) occurring after delivery by cesarean section. Hysteroscopic treatment for RPOC has a low incidence of severe intrauterine adhesions formation.
We identified a novel nonsense mutation p.E142X in EMX2, resulting in truncated protein with a dominant negative effect. It reinforced the likelihood that EMX2 contributed to the pathophysiology of IMF.
In a retrospective study of patients with neurofibromatosis 1 (NF1) undergoing preimplantation genetic diagnosis, only 37%of all biopsied embryoswere confirmed tobe unaffectedbyNF1, and at least 27%of couples achieved a live birth
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