An examination of the surface proteome of prereceptive and receptive mouse luminal endometrium by two-dimensional liquid chromatography with tandem mass spectrometry found 45 proteins to be differentially expressed.

Fibroid-derived TGF-b3 alters endometrial BMP-2 signaling and prevents up-regulation of HOXA10 and leukemia inhibitory factor. The TGF-b blockade restoresBMP-2 stimulation ofHOXA10 and leukemia inhibitory factor andmay improve endometrial receptivity.

miR-451 is specifically up-regulated during the implantation period and affects embryo implantation by conversely regulating Ankrd46, implicated by a microarray-based analysis.

Administration of human chorionic gonadotropin induces granulosa cell expression of mRNA for the proteinases MMP1, MMP19, ADAMTS1, and ADAMTS9 in the dominant follicle collected across the periovulatory period of the menstrual cycle.

Benzo(a)pyrene disrupts mouse preimplantation embryo development by increasing reactive oxygen species level, inducing genomic and telomeric DNA damage and cell apoptosis, and reducing inner cell mass ratio.

Low birth weight may influence the appearance of hyperandrogenism and insulin resistance in some adolescents with polycystic ovary syndrome, but in the majority factors other than birth weight are implicated.

MiR-22-3p showed a lower expression level in 140 premature ovarian failure (POF) patients and was modestly effective in distinguishing POF from control subjects. It may be a consequence of the pathologic process of POF.

The presence of adrenal hyperandrogenism in women with polycystic ovary syndrome is associated with reduced insulin sensitivity and increased blood pressure, but may have a beneficial impact on the lipid profile.

Associations between ultrasound features and reproductive and metabolic markers in women with polycystic ovary syndrome (PCOS) were assessed. Follicle populations reflected the severity of reproductive and metabolic dysfunction in PCOS.

Immunohistochemistry and intraindividual variation, as well as relations to other ovarian hormones, reveal that INSL3 is a unique and specific marker of theca cells of antral follicles.

Risk factors for intrauterine adhesions include retained products of conception (RPOC) occurring after delivery by cesarean section. Hysteroscopic treatment for RPOC has a low incidence of severe intrauterine adhesions formation.

We identified a novel nonsense mutation p.E142X in EMX2, resulting in truncated protein with a dominant negative effect. It reinforced the likelihood that EMX2 contributed to the pathophysiology of IMF.

In a retrospective study of patients with neurofibromatosis 1 (NF1) undergoing preimplantation genetic diagnosis, only 37%of all biopsied embryoswere confirmed tobe unaffectedbyNF1, and at least 27%of couples achieved a live birth

High incidence of monozygotic twinning in infertility clinic patients is conditioned by hereditary factors, and good ovarian function only facilitates the expression.

Pretreatment intake of soy foods and soy isoflavones was positively related to the probability of live birth in a prospective cohort of women undergoing assisted reproduction.

Body mass index was not associated with the number or percent of euploid embryos in patients undergoing 24-chromosome pre-implantation genetic screening.

Surgery for recurrent endometriomas is associated with histologic evidence of higher loss of ovarian tissue, and is more harmful to the ovarian reserve than first surgery.

In ampullary pregnancies, higher serum levels of VEGF are associated with the ultrasound finding of an embryo with cardiac activity.

Clinical pregnancy and live birth rates after embryo transfers performed by reproductive endocrinology and infertility fellows were unchanged after an 18-month lapse in clinical training.

Methylation analysis of 15 developmentally important genes and 2 repeats in 11 IVM children and 19 controls did not provide evidence for IVM-induced epigenetic changes.