Contained morcellation of uterine tissue is readily accomplished via a laparoscopic approach within an insufflated endoscopic pouch, or via ultraminilaparotomy using a flexible, self-retaining retractor.

This video describes the surgical anatomy of the supraumbilical region and the distances of the port sites at 1-cm increments from the umbilicus in relation to the great vessels.

Berberine inhibits proliferation of leiomyoma cells and may serve as a potential therapeutic agent for the medical treatment of uterine leiomyomas.

The present study showed that increased Pak4 expression can lead to the development of adenomyosis by enhancing the invasiveness of endometrial cells through regulating MMP-2 and -9 activities.

An FSH receptor polymorphism (rs6166) affects the outcome of ovulation induction in normogonadotropic anovulatory subfertility. The minor allele (680Ser) is associated with Clomiphene-resistant anovulation during treatment with clomiphene citrate.

An automated antimullerian hormone assay showed good correlations with age and antral follicle count and is a reproducible measure of the growing follicle pool.

In this registry-based cohort study, we found positive associations between prospectively measured time to pregnancy and several adverse birth outcomes, including preterm birth, low birth weight, placental disorders, gestational diabetes, and cesarean section.

The present study reveals that blood and tissue levels of Mucin 1 and Glycodelin A are much lower in women with recurrent implantation failure than in fertile women.

In this birth cohort, 21.8% of men and 26.0% of women had ever tried to conceive for 12 months or more or sought medical help to conceive by age 38.

Women with chronic endometritis show altered uterine motility in both the periovulatory and midluteal phases.

Women with a time interval from LEEP to pregnancy of

Twenty-four–chromosome preimplantation genetic diagnosis in translocation carriers yields a live birth rate of 52% per embryo transfer and 38% per biopsy cycle. Thirty percent of cycles had no euploid embryos.

In a prospective trial, use of semiconductor-based NGS for PGD was found to provide a significant advantage in improving pregnancy rate.

Additional congenital abnormalities and regions of genomic imbalance are common in women with mullerian disorders, including Mayer-Rokitanksy-Kuster-Hauser syndrome. These women should be thoroughly investigated, and array comparative genomic hybridization should be considered.

Elevated TCS exposure may be associated with diminished fecundity. BPA and phthalates showed no negative impact; on the contrary, some phthalates might be associated with a shorter time to pregnancy. A major limitation of the study was that only one measurement of exposure was available for each woman after conception. Further research is necessary to test these findings.

This registry-based study suggests that the associations between IVF/ICSI and penoscrotal hypospadia and imprinting disorders reported in the literature are better explained by the underlying subfertility than by IVF/ICSI treatment.

P-selectin deficiency significantly retarded the development of endometriosis in a mouse model, and soluble P-selectin treatment markedly reduced lesion size in mice through decreased platelet aggregation and angiogenesis, resulting in reduced fibrotic tissue content.

MicroRNA expression profiles were significantly altered between miscarriage and normal pregnancy deciduas. MicroRNA-199b-5p and SGK1 were detected to determine their interaction in pregnancy maintenance in vivo and in vitro.

Singletons born to primiparous women using assisted reproductive technology had increased risk for preterm birth compared with those conceived spontaneously. The increased risk was observed along the gestational age continuum.

The baseline characteristics are provided for women with unexplained infertility who participated in the AMIGOS trial examining ovarian stimulation with gonadotropins, CC, and letrozole.

Almost half of ART-related multiple births result from transferring two fresh blastocysts to favorable or average-prognosis patients

Euploidy outcomes were compared in patients that underwent two ovarian stimulation cycles with preimplantation genetic screening; no specific intervention increased the number of euploid embryos within the same patient any more than simply repeating a similar stimulation cycle.

Initiation of progesterone for luteal support may impact pregnancy rates (PRs). Starting progesterone before oocyte retrieval or 6 days after retrieval likely decreases PRs.

A higher number of retrieved oocytes was associated with an increased incidence of low birth weight in autologous, but not donor, oocyte cycles with fresh transfer of two embryos.

Antimullerian hormone was a stronger predictor of ovarian response to controlled ovarian stimulation than AFC in both GnRH agonist and antagonist cycles, also when data were evaluated at the study center level.

This external validation study failed to replicate the performance of the time-lapse published prediction model, but it should inspire each center to build its own prediction model.

The negative effect of sperm DNA fragmentation on clinical outcomes of IVF and ICSI is greater in women with reduced ovarian reserve compared with those with normal ovarian reserve.

Men with recurrent pregnancy loss and normal semen parameters exhibit increased sperm aneuploidy detected by fluorescence in situ hybridization.

Reflections on “Loop electrosurgical excision procedure and risk of miscarriage” by Ciavattini et al.

Reflections on “Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) Trial: baseline characteristics” by Diamond et al.

Reflections on “FSH receptor polymorphism affects the outcome of ovulation induction in normogonadotropic (WHO2) anovulatory infertility” by Valkenburg et al.

Reflections on “Embryo transfer practices and multiple births resulting from assisted reproductive technology: an opportunity for prevention” by Kissin et al.

Reflections on “Perinatal outcomes associated with assisted reproductive technology: the Massachusetts Outcomes Study of Assisted Reproductive Technologies (MOSART)” by Declercq et al.

This committee opinion addresses controversies regarding the diagnosis and potential treatment of luteal phase inadequacy.

Comparing assisted reproductive technology (ART) singleton births with subfertile births found significantly higher rates of preterm birth and low birth weight in the ART cohort. Among twins, ART births had significantly lower perinatal death rates.

Endometriosis is a benign inflammatory disease defined by the presence of endometrial glands and stroma in areas outside the uterus. It is estimated to affect 5%–15% of women of reproductive age and is even more prevalent among women with chronic pelvic pain and infertility. Endometriotic implants may be located anywhere within the pelvis, including the ovaries, ovarian fossa, pelvic peritoneum, rectovaginal septum, uterosacral ligaments, and cul-de sac. In some cases, ovarian endometriotic cysts (endometriomas) may be observed by ultrasound imaging.

We describe two luteal phase support protocols after gonadotropin-releasing hormone agonist trigger: the European and the American approaches. Both concepts facilitate fresh embryo transfer with excellent reproductive outcomes in the ovarian hyperstimulation syndrome–risk patient.

High responders and oocyte donors may now be stimulated and triggered with reasonable safety. This paradigm shift confers certain advantages and potential new risks.

This paper describes the pathophysiology of ovarian hyperstimulation syndrome (OHSS), focusing specifically on the luteolytic benefits of the use of GnRH agonist to decrease OHSS and the possible rescue modalities available.

A bolus of GnRH agonist induces a midcycle gonadotropin surge that is more physiologic in duration and quality compared with a bolus dose of human chorionic gonadotropin for oocyte maturation and ovulation.