The authors review the evidence connecting women’s extended fertility with longevity. The connection relies on the synthesis of data from epidemiology, genomics, epigenomics, and gene expression.
Interest in reproduction among women of advanced reproductive age remains at historic levels. Promoting postponed childbearing should be balanced by presentation of the associated perils of delay.
The use of testosterone in men has become extremely controversial over the past year. Stakeholders in this topic include physicians who prescribe testosterone, patients—both those who feel that they benefited from treatment, and those who feel they have been harmed by treatment, the pharmaceutical companies, the federal government through the Food and Drug Administration (FDA), and litigation attorneys who have placed ads suggesting lawsuits for patients that have been on testosterone therapy and may have had cardiovascular events.
In the fall of 2014, the first assisted reproductive technology (ART) program opened in Cambodia. This event took place in Phnom Penh 35 years after Cambodia emerged—in the early days of 1979—from the worst geopolitical nightmare and genocide that the world has known since the Holocaust. In nearly 4 years of abuse, the Khmer Rouge regime through active killing and starvation had exterminated a third of the country’s population, who perished in the Killing Fields. In January 1979—the nightmare suddenly over—the country stood in rags and tears, with all needing to be rebuilt from scratch while wounds healed.
Reflections on “G protein–coupled estrogen receptor 1 agonist G-1 induces cell cycle 1 arrest in the mitotic phase, leading to apoptosis in endometriosis” by Mori et al.
Reflections on “The relationship between physical occupational exposures and health on semen quality: Data from the LIFE Study” by Eisenberg et al.
Ability of Escherichia coli to produce hemolysis leads to a greater pathogenic effect on human sperm
Hemolytic Escherichia coli demonstrated a strain-dependent effect, altering all sperm variables studied, in contrast to nonhemolytic strains, which differentially impair sperm function.
Meiotic and sperm aneuploidy studies in three carriers of Robertsonian translocations and small supernumerary marker chromosomes
A novel technique using immunofluorescence techniques on spermatocytes obtained from ejaculate samples was used to examine segregation and meiosis in carriers of Robertsonian translocations and small supernumerary marker chromosomes.
Antral follicle count is not predictive of pregnancy or miscarriage in patients undergoing unstimulated therapeutic donor insemination cycles for indications of an azoospermic male partner or the absence of a male partner.
Cryopreserved embryo transfer is a strong predictor of placenta accreta among patients using in vitro fertilization and/or intracytoplasmic sperm injection. This increased risk may be associated with the thinner endometrial linings and lower estradiol levels characteristic of these cycles.
Monozygotic twinning after assisted reproductive technologies: a case report of asymmetric development and incidence during 19 years in an international group of in vitro fertilization clinics
We report a case of monozygotic twinning with asymmetric development after a single-embryo transfer. We also estimate the incidence of monozygotic twinning in our IVF clinics.
Even in patients that undergo fresh embryo transfer without progesterone elevation, endometrial receptivity may be impaired by controlled ovarian stimulation, and outcomes may be improved by using the freeze-all policy.
Comparison of live birth defects after luteal phase ovarian stimulation vs conventional ovarian stimulation for in vitro fertilization and vitrified embryo transfer cycles
No evidence was found of detrimental effects of luteal-phase ovarian stimulation on live-born infants at birth. Infertility itself and multiple births pose risk factors for congenital malformation.
MicroRNAs with cell-free pregnancy have potential as molecular markers for ectopic pregnancy diagnosis.
Pregnancies with vanishing twin syndrome are associated with an adverse perinatal outcome, as compared with singletons and twins, even after controlling for confounders such as fertility treatment and maternal age.