Roles of ZEB1 in cervical cancers suggested that ZEB1 might be a potential therapeutic target for SCC.

The BMDCs might improve uterine tissue as a valuable source for endometrial restoration.

A specific phosphodiesterase type 5 inhibitor, sildenafil, promotes extravillous differentiation and increases invasiveness of first-trimester trophoblast cells through the nitricoxide–driven cGMPpathway.

We discuss a series of immunologic alterations are associated with endoplasmic reticulum stress during the window of implantation in the endometrium of infertile women.

Among midlife women, more physiologically-monitored hot flashes, particularly during sleep, were associated with greater default mode network connectivity, particularly for networks supporting the hippocampus.

Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.

This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.

Based on a decision-tree analysis, elective egg freezing is most successful if performed before the age of 34 years but is most cost-effective at the age of 37 years.

The capacity of antral follicule count to predict ovarian responsiveness during in vitro fertilization is similar among unaffected ovaries, ovaries with endometriomas, and previously operated ovaries.

Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.

Previously euthyroid women with infertility or recurrent pregnancy loss and negative thyroid peroxidase antibodies had a 24% incidence of hypothyroidism (TSH 2.5) at the time of pregnancy detection.

Mean human chorionic gonadotropin levels resulting from a single fresh blastocyst transfer were significantly higher than those from a single cleavage transfer after adjusting for confounding variables.

Sterilization by hysteroscopy seems feasible, but the effectiveness and risk factors for failure of sterilization remain unclear owing to the poor-quality evidence.

Frequent use of sterilization by unmarried women highlights the importance of educating women on the permanency of sterilization, and an opportunity to increase reliance on long-acting reversible contraceptives.

We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.

Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.

Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.

We discuss how poor response to controlled ovarian hyperstimulation in in vitro fertilization is associated with altered microRNA expression in cumulus cells.

The validity of maternally reported assisted reproductive treatment use is high, with no strong predictors found for discordant reporting, supporting the design of population-based research.

Single vitrified-warmed blastocyst transfer provides excellent live-birth rates and higher embryo to live-birth efficiency while minimizing preterm birth and low birth weight, relative to double transfer.

This cost analysis demonstrates that in women who plan to delay childbearing until age 40 years, oocyte cryopreservation before 38 years of age can reduce the cost to obtain a live birth.

Women with infertility-related diagnoses had an excess of perinatal morbidity even in the absence of assisted reproductive technology treatment.

Early rescue intracytoplasmic sperm injection can result in a similar rate of clinical pregnancies when compared with conventional in vitro fertilization/intracytoplasmic sperm injection, as well as delivery of healthy newborns.

This study demonstrates a decrease of global methylation and unchanged acetylation level in ejaculated human sperm after the swim-up preparation.

Reflections on “Endometriosis and assisted reproductive technology: United States trends and outcomes 2000–2011” by Kawwass et al.

Reflections on “Are good prognosis patient and embryo characteristics protective from the negative effect of elevated progesterone on the day of HCG trigger?” by Hill et al.

This committee opinion assesses current methods and procedures for evaluation of infertile women.

This document reviews surgical options for achieving patency in obstructed fallopian tubes and the factors that must be considered when deciding between surgical repair and IVF.

This document discusses the use of reproductive technology to select the sex of offspring for nonmedical reasons.

The article presents a systematic review of the addition of adherence compounds to the embryo transfer medium used in assisted reproductive technologies.

We discuss how the global metabolomic profile of the spent culture media from day-3 embryos is different when obese and normoweight women are compared.

Despite relatively rare, although potentially serious, risks to offspring, advanced paternal age should not be a contraindication for conception.

We discuss whether advanced maternal age has long-term effects through inheritance of the mitochondrial DNA, apart from the immediate consequences of maternal age on reproduction.

Paternal aging predicts increasing risks for offspring schizophrenia, autism, bipolar disorder, and other behavioral conditions. De novo mutations are implicated, but other interrelated factors are being studied, including paternal age at marriage, duration of marriage, and maternal age.

Older maternal age appears to exert a protective effect on offspring behavioral and cognitive outcomes. The extent to which this relationship is causal remains unclear.

We discuss how societal changes have led to increasing parental age with potential impact on childhood health. The differences in gamete biology may be keys to understanding these risks.