ZEB1 promotes epithelial mesenchymal transition in cervical cancer metastasis
Roles of ZEB1 in cervical cancers suggested that ZEB1 might be a potential therapeutic target for SCC.
June 2015
All the papers from the June 2015 issue of Fertility and Sterility.
Contribution of different bone marrow derived cell types in endometrial regeneration using an irradiated murine model
The BMDCs might improve uterine tissue as a valuable source for endometrial restoration.
Sildenafil stimulates human trophoblast invasion through nitric oxide and guanosine 3 5 cyclic monophosphate signaling
A specific phosphodiesterase type 5 inhibitor, sildenafil, promotes extravillous differentiation and increases invasiveness of first-trimester trophoblast cells through the nitricoxide–driven cGMPpathway.
Regulatory T cells inflammation and endoplasmic reticulum stress in women with defective endometrial receptivity
We discuss a series of immunologic alterations are associated with endoplasmic reticulum stress during the window of implantation in the endometrium of infertile women.
Menopausal hot flashes and the default mode network
Among midlife women, more physiologically-monitored hot flashes, particularly during sleep, were associated with greater default mode network connectivity, particularly for networks supporting the hippocampus.
Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG island amplification coupled with CpG island microarray
Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.
Xenotransplantation of cryopreserved human ovarian tissue A systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment
This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.
Optimal timing for elective egg freezing
Based on a decision-tree analysis, elective egg freezing is most successful if performed before the age of 34 years but is most cost-effective at the age of 37 years.
Antral follicle count as a predictor of ovarian responsiveness in women with endometriomas or with a history of surgery for endometriomas
The capacity of antral follicule count to predict ovarian responsiveness during in vitro fertilization is similar among unaffected ovaries, ovaries with endometriomas, and previously operated ovaries.
Endometriosis and Assisted Reproductive Technology United States Trends and Outcomes 2000 2011
Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.
Gestational hypothyroidism Development of mild hypothyroidism in early pregnancy in previously euthyroid women
Previously euthyroid women with infertility or recurrent pregnancy loss and negative thyroid peroxidase antibodies had a 24% incidence of hypothyroidism (TSH 2.5) at the time of pregnancy detection.
Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers
Mean human chorionic gonadotropin levels resulting from a single fresh blastocyst transfer were significantly higher than those from a single cleavage transfer after adjusting for confounding variables.
Effectiveness and feasibility of hysteroscopic sterilization techniques A systematic review and meta analysis
Sterilization by hysteroscopy seems feasible, but the effectiveness and risk factors for failure of sterilization remain unclear owing to the poor-quality evidence.
Marital status and female and male contraceptive sterilization in the United States
Frequent use of sterilization by unmarried women highlights the importance of educating women on the permanency of sterilization, and an opportunity to increase reliance on long-acting reversible contraceptives.
Pregnancy related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology A meta analysis of cohort studies
We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.
Clinical significance of intercellular contact at the four cell stage of human embryos and the use of abnormal cleavage patterns to identify embryos with low implantation potential A time lapse study
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.
Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation
Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
We discuss how poor response to controlled ovarian hyperstimulation in in vitro fertilization is associated with altered microRNA expression in cumulus cells.
Use of assisted reproductive technology treatment as reported by mothers in comparison with registry data The Upstate KIDS Study
The validity of maternally reported assisted reproductive treatment use is high, with no strong predictors found for discordant reporting, supporting the design of population-based research.
Single vitrified blastocyst transfer maximizes liveborn children per embryo while minimizing preterm birth
Single vitrified-warmed blastocyst transfer provides excellent live-birth rates and higher embryo to live-birth efficiency while minimizing preterm birth and low birth weight, relative to double transfer.
Baby budgeting Oocyte cryopreservation in women delaying reproduction can reduce cost per live birth
This cost analysis demonstrates that in women who plan to delay childbearing until age 40 years, oocyte cryopreservation before 38 years of age can reduce the cost to obtain a live birth.
Adverse pregnancy and birth outcomes associated with underlying diagnosis with and without assisted reproductive technology treatment
Women with infertility-related diagnoses had an excess of perinatal morbidity even in the absence of assisted reproductive technology treatment.
Neonatal outcomes after early rescue intracytoplasmic sperm injection An analysis of a 5 year period
Early rescue intracytoplasmic sperm injection can result in a similar rate of clinical pregnancies when compared with conventional in vitro fertilization/intracytoplasmic sperm injection, as well as delivery of healthy newborns.
Histone methylation and acetylation in ejaculated human sperm Effects of swim up and smoking
This study demonstrates a decrease of global methylation and unchanged acetylation level in ejaculated human sperm after the swim-up preparation.
Perils and promise in big data
Reflections on “Endometriosis and assisted reproductive technology: United States trends and outcomes 2000–2011” by Kawwass et al.
High responders and patients with a good prognosis are not immune to the negative impact on live birth rate of elevated P on the day of triggering
Reflections on “Are good prognosis patient and embryo characteristics protective from the negative effect of elevated progesterone on the day of HCG trigger?” by Hill et al.
Diagnostic evaluation of the infertile female A committee opinion
This committee opinion assesses current methods and procedures for evaluation of infertile women.
Role of tubal surgery in the era of assisted reproductive technology A committee opinion
This document reviews surgical options for achieving patency in obstructed fallopian tubes and the factors that must be considered when deciding between surgical repair and IVF.
Use of reproductive technology for sex selection for nonmedical reasons
This document discusses the use of reproductive technology to select the sex of offspring for nonmedical reasons.
Adherence compounds in embryo transfer media for assisted reproductive technologies Summary of a Cochrane review
The article presents a systematic review of the addition of adherence compounds to the embryo transfer medium used in assisted reproductive technologies.
Day 3 embryo metabolomics in the spent culture media is altered in obese women undergoing in vitro fertilization
We discuss how the global metabolomic profile of the spent culture media from day-3 embryos is different when obese and normoweight women are compared.
Male biological clock A critical analysis of advanced paternal age
Despite relatively rare, although potentially serious, risks to offspring, advanced paternal age should not be a contraindication for conception.
Potential long term risks associated with maternal aging the role of the mitochondria
We discuss whether advanced maternal age has long-term effects through inheritance of the mitochondrial DNA, apart from the immediate consequences of maternal age on reproduction.
Paternal age and mental health of offspring
Paternal aging predicts increasing risks for offspring schizophrenia, autism, bipolar disorder, and other behavioral conditions. De novo mutations are implicated, but other interrelated factors are being studied, including paternal age at marriage, duration of marriage, and maternal age.
Older maternal age and child behavioral and cognitive outcomes A review of the literature
Older maternal age appears to exert a protective effect on offspring behavioral and cognitive outcomes. The extent to which this relationship is causal remains unclear.
Childhood implications of parental aging
We discuss how societal changes have led to increasing parental age with potential impact on childhood health. The differences in gamete biology may be keys to understanding these risks.