A specific phosphodiesterase type 5 inhibitor, sildenafil, promotes extravillous differentiation and increases invasiveness of first-trimester trophoblast cells through the nitricoxide–driven cGMPpathway.
We discuss a series of immunologic alterations are associated with endoplasmic reticulum stress during the window of implantation in the endometrium of infertile women.
Among midlife women, more physiologically-monitored hot flashes, particularly during sleep, were associated with greater default mode network connectivity, particularly for networks supporting the hippocampus.
Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.
This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.
Based on a decision-tree analysis, elective egg freezing is most successful if performed before the age of 34 years but is most cost-effective at the age of 37 years.
The capacity of antral follicule count to predict ovarian responsiveness during in vitro fertilization is similar among unaffected ovaries, ovaries with endometriomas, and previously operated ovaries.
Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.
Previously euthyroid women with infertility or recurrent pregnancy loss and negative thyroid peroxidase antibodies had a 24% incidence of hypothyroidism (TSH 2.5) at the time of pregnancy detection.
Mean human chorionic gonadotropin levels resulting from a single fresh blastocyst transfer were significantly higher than those from a single cleavage transfer after adjusting for confounding variables.
Sterilization by hysteroscopy seems feasible, but the effectiveness and risk factors for failure of sterilization remain unclear owing to the poor-quality evidence.
Frequent use of sterilization by unmarried women highlights the importance of educating women on the permanency of sterilization, and an opportunity to increase reliance on long-acting reversible contraceptives.
We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.
Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.
We discuss how poor response to controlled ovarian hyperstimulation in in vitro fertilization is associated with altered microRNA expression in cumulus cells.
The validity of maternally reported assisted reproductive treatment use is high, with no strong predictors found for discordant reporting, supporting the design of population-based research.
Single vitrified-warmed blastocyst transfer provides excellent live-birth rates and higher embryo to live-birth efficiency while minimizing preterm birth and low birth weight, relative to double transfer.
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