Roles of ZEB1 in cervical cancers suggested that ZEB1 might be a potential therapeutic target for SCC.
All the papers from the June 2015 issue of Fertility and Sterility.
Contribution of different bone marrow derived cell types in endometrial regeneration using an irradiated murine model
The BMDCs might improve uterine tissue as a valuable source for endometrial restoration.
Sildenafil stimulates human trophoblast invasion through nitric oxide and guanosine 3 5 cyclic monophosphate signaling
A specific phosphodiesterase type 5 inhibitor, sildenafil, promotes extravillous differentiation and increases invasiveness of first-trimester trophoblast cells through the nitricoxide–driven cGMPpathway.
Regulatory T cells inflammation and endoplasmic reticulum stress in women with defective endometrial receptivity
We discuss a series of immunologic alterations are associated with endoplasmic reticulum stress during the window of implantation in the endometrium of infertile women.
Among midlife women, more physiologically-monitored hot flashes, particularly during sleep, were associated with greater default mode network connectivity, particularly for networks supporting the hippocampus.
Deoxyribonucleic acid methylation profiling of single human blastocysts by methylated CpG island amplification coupled with CpG island microarray
Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.
Xenotransplantation of cryopreserved human ovarian tissue A systematic review of MII oocyte maturation and discussion of it as a realistic option for restoring fertility after cancer treatment
This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.
Antral follicle count as a predictor of ovarian responsiveness in women with endometriomas or with a history of surgery for endometriomas
The capacity of antral follicule count to predict ovarian responsiveness during in vitro fertilization is similar among unaffected ovaries, ovaries with endometriomas, and previously operated ovaries.
Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.
Gestational hypothyroidism Development of mild hypothyroidism in early pregnancy in previously euthyroid women
Previously euthyroid women with infertility or recurrent pregnancy loss and negative thyroid peroxidase antibodies had a 24% incidence of hypothyroidism (TSH 2.5) at the time of pregnancy detection.
Predictive value of maternal serum human chorionic gonadotropin levels in pregnancies achieved by in vitro fertilization with single cleavage and single blastocyst embryo transfers
Mean human chorionic gonadotropin levels resulting from a single fresh blastocyst transfer were significantly higher than those from a single cleavage transfer after adjusting for confounding variables.
Effectiveness and feasibility of hysteroscopic sterilization techniques A systematic review and meta analysis
Sterilization by hysteroscopy seems feasible, but the effectiveness and risk factors for failure of sterilization remain unclear owing to the poor-quality evidence.
Frequent use of sterilization by unmarried women highlights the importance of educating women on the permanency of sterilization, and an opportunity to increase reliance on long-acting reversible contraceptives.
Pregnancy related complications and adverse pregnancy outcomes in multiple pregnancies resulting from assisted reproductive technology A meta analysis of cohort studies
We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.
Clinical significance of intercellular contact at the four cell stage of human embryos and the use of abnormal cleavage patterns to identify embryos with low implantation potential A time lapse study
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.
Are good patient and embryo characteristics protective against the negative effect of elevated progesterone level on the day of oocyte maturation
Elevated P level on the day of human chorionic gonadotropin administration negatively affects live-birth rate, regardless of embryo stage, embryo quality, patient age, or ovarian response.
Poor ovarian response in women undergoing in vitro fertilization is associated with altered microRNA expression in cumulus cells
We discuss how poor response to controlled ovarian hyperstimulation in in vitro fertilization is associated with altered microRNA expression in cumulus cells.
Use of assisted reproductive technology treatment as reported by mothers in comparison with registry data The Upstate KIDS Study
The validity of maternally reported assisted reproductive treatment use is high, with no strong predictors found for discordant reporting, supporting the design of population-based research.
Single vitrified blastocyst transfer maximizes liveborn children per embryo while minimizing preterm birth
Single vitrified-warmed blastocyst transfer provides excellent live-birth rates and higher embryo to live-birth efficiency while minimizing preterm birth and low birth weight, relative to double transfer.