A specific phosphodiesterase type 5 inhibitor, sildenafil, promotes extravillous differentiation and increases invasiveness of first-trimester trophoblast cells through the nitricoxide–driven cGMPpathway.
Among midlife women, more physiologically-monitored hot flashes, particularly during sleep, were associated with greater default mode network connectivity, particularly for networks supporting the hippocampus.
Methylated CpG-island amplification coupled with CpG-island microarray was used to assess DNA methylation in individual in vitro–derived human blastocysts, revealing 121 CpG islands that were hypermethylated in all 5 embryos.
This review discusses the value of xenotransplantation as a tool in reproductive biology and ethical and potential safety issues associated with ovarian tissue xenotransplantation as a means of restoring fertility.
Among assisted reproductive technology cycles, endometriosis, compared with male factor infertility, is associated with increased cycle cancellation, decreased hyperstimulation, and slightly lower but likely clinically comparable live-birth rates.
Mean human chorionic gonadotropin levels resulting from a single fresh blastocyst transfer were significantly higher than those from a single cleavage transfer after adjusting for confounding variables.
Frequent use of sterilization by unmarried women highlights the importance of educating women on the permanency of sterilization, and an opportunity to increase reliance on long-acting reversible contraceptives.
We present an up-to-date comparison of pregnancy-related complications and adverse pregnancy outcomes of multiple pregnancies generated with assisted reproductive technology versus spontaneous conception.
Reduced intercellular contact in four-cell stage human embryos leads to compromised subsequent development and implantation potential. Implantation rates could be improved by not selecting embryos showing abnormal cleavage patterns.
Single vitrified-warmed blastocyst transfer provides excellent live-birth rates and higher embryo to live-birth efficiency while minimizing preterm birth and low birth weight, relative to double transfer.
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