In cases of congenital bilateral absence of the vas deferens, advanced paternal age has a negative effect on retrieved-sperm parameters.

Spermatozoa from infertile patients with asthenozoospermia, teratozoospermia, or oligozoospermia exhibit a differential miRNA profile associated with biological processes related to their particular seminal alterations.

Detecting sperm DNA fragmentation by means of TUNEL/PI predicts male fertility status independently from age and semen parameters, providing additional information in routine semen analysis.

γH2AX might be a useful biomarker for evaluating double-stranded breaks in human spermatozoa.

The sperm retrieval rate using microdissection testicular sperm extraction in men with maturation arrest is 52%; men with late maturation arrest and higher follicle-stimulating hormone levels have the highest rates.

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C Zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection, but not after in vitro fertilization.

Reflections on “Role of vitamin D in uterine fibroid biology” by Brakta et al.

Reflections on “Mitochondrial DNA content as a viability score in human embryos: less is better” by Diez-Juan et al.

Reflections on “Risk factors for a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles” by Meyer et al.

Reflections on “Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile” by Salas-Huetos et al.

This guideline document reviews the definition and treatment recommendation for subclinical hypothyroidism in the infertile female population.

We conducted a systematic review of the use of metformin as a cotreatment during in vitro fertilization and during intracytoplasmic sperm injection in women with polycystic ovary syndrome.

Higher mitochondrial DNA content in euploid human embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.

In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.

We have set out from here for the sublime. I have no doubt we shall arrive on time. 'Prospects' by Anthony Hecht.

The rise of the Internet Age has brought significant change to third-party reproduction. The implications of the freer informational exchange between third-party participants are examined. Recommendations are made regarding strategies fertility programs can use to navigate this new landscape.

Third-party reproduction is rapidly increasing. It involves a number of complex decisions that are better negotiated with guidance from a mental health professional.

The well-being of donor-conceived children is reviewed, disclosure trends are discussed, and child-related consequences of older parents using donor conception are considered with the goal of promoting the welfare of the child.

Mandatory counseling of gamete recipients is fraught with ethical questions for the mental health professional. Attention to issues of autonomy, confidentiality, and role clarity can diminish ethical conflicts.

Mental health professionals perform a psychoeducational role with intended parents, and evaluation with donors/surrogates; gatekeeping about ethics should be a team decision.