The cannabinoid system is present in human granulosa cells. The expression pattern of each component does not change during oocyte maturation.

Adenomyosis highly expresses myostatin, follistatin and activin A, as well as activin receptors (ActRIIa and ActRIIb).

An altered apoptotic pathway in impaired spermatogenic cases leads to infertility in males.

Tripronucleated-ICSI human embryos (TPN) display different morphokinetic behaviour according to ploidy; TPN-ICSI that self-correct to diploidy are morphokinetically closer to correctly fertilized embryos. The morphokinetic variable t5 can predict ploidy.

Coenzyme Q (CoQ)-dependent mitochondrial activity in granulosa cells reduces with aging and is restored via supplementation, indicating that functional CoQ10 deficit is the main underlying cause for oxidative phosphorylation dysfunction.

Long-term intranasal oxytocin and placebo administration improve sexual function and symptoms of depression in women over time with no treatment, sequence (placebo first/second), or interaction effect.

Insulin resistance was found to be linked to depression risk, after controlling for potential confounders, in women who have polycystic ovary syndrome.

Vitamin D3 or its hypocalcemic analog, paricalcitol, may be a novel therapeutic approach as an effective, safe, nonsurgical treatment option for uterine fibroids.

Comprehensive preimplantation genetic screening and sperm DNA fragmentation analysis may play a role in predicting reproductive outcomes in IVF cycles for males carrying balanced chromosome reorganizations.

Cancer cells present in ovarian tissue may be found in isolated follicle suspensions. Manually washing the follicles three times proved effective for eliminating cancer cells while maintaining good follicle viability.

We conducted a meta-analysis and identified a significant but not strong association between thyroid antibodies and gestational diabetes mellitus, and that thyroid antibodies in the first trimester lack predictive value for gestational diabetes mellitus risk.

Dienogest promotes the induction of autophagy in endometriotic cells by suppressing protein kinase B and extracellular-signal-regulated kinase 1/2 activity, which results in mTOR inhibition, ultimately leading to increased apoptosis.

Introducing the slope of linear regression of b-human chorionic gonadotropin as an new independent risk factor for gestational trophoblastic neoplasia was demonstrated to be clinically justfiable and suitable to be considered in prevention programs.

Using a cut point of 0.5 ng/mL, antimullerian hormone (AMH) performs well to identify patients at risk of failure of ovarian stimulation for in vitro fertilization. PicoAMH does not provide superior ability to predict failed response.

Risk factors for suboptimal response to gonadotropin-releasing hormone agonist-agonist trigger include low luteinizing hormone (LH) and follicle stimulating hormone on in vitro fertilization cycle start day, low LH on trigger day, history of irregular menses, and long-term oral contraceptive use.

Antimullerian hormone (AMH) levels <1 ng/mL are associated with a statistically significantly lower likelihood of supernumerary good-quality blastocyst cryopreservation as compared with AMH levels between 1 and 4 ng/mL.

Monochorionic twins after assisted reproductive technology (ART) are at increased risk of adverse perinatal outcomes compared with spontaneous monochorionic twins and with dichorionc twins conceived by ART.

Endometrial pattern, but not thickness, on trigger day affected a patient’s chance of achieving a pregnancy. The pattern or thickness at embryo transfer had no effect.

Diminished ovarian reserve (DOR) assignment increased 7% among all Society for Assisted Reproductive Technology Clinic Outcomes Reporting System cycles from 2004 to 2011, despite minimal increase in patient age at cycle start. The ability of DOR assignment to predict poor ovarian response worsened.

Transfer of nonpronuclear (0PN) embryos results in pregnancies and live births. Blastocyst cultures can provide a better way to select normal 0PN embryos for transfer and thus achieve satisfactory outcomes.

In cases of congenital bilateral absence of the vas deferens, advanced paternal age has a negative effect on retrieved-sperm parameters.

Spermatozoa from infertile patients with asthenozoospermia, teratozoospermia, or oligozoospermia exhibit a differential miRNA profile associated with biological processes related to their particular seminal alterations.

Detecting sperm DNA fragmentation by means of TUNEL/PI predicts male fertility status independently from age and semen parameters, providing additional information in routine semen analysis.

γH2AX might be a useful biomarker for evaluating double-stranded breaks in human spermatozoa.

The sperm retrieval rate using microdissection testicular sperm extraction in men with maturation arrest is 52%; men with late maturation arrest and higher follicle-stimulating hormone levels have the highest rates.

Total levels, localization patterns, and proportions of sperm exhibiting phospholipase C Zeta are significantly correlated with fertilization rates after intracytoplasmic sperm injection, but not after in vitro fertilization.

Reflections on “Role of vitamin D in uterine fibroid biology” by Brakta et al.

Reflections on “Mitochondrial DNA content as a viability score in human embryos: less is better” by Diez-Juan et al.

Reflections on “Risk factors for a suboptimal response to gonadotropin-releasing hormone agonist trigger during in vitro fertilization cycles” by Meyer et al.

Reflections on “Spermatozoa from patients with seminal alterations exhibit a differential miRNA profile” by Salas-Huetos et al.

This guideline document reviews the definition and treatment recommendation for subclinical hypothyroidism in the infertile female population.

We conducted a systematic review of the use of metformin as a cotreatment during in vitro fertilization and during intracytoplasmic sperm injection in women with polycystic ovary syndrome.

Higher mitochondrial DNA content in euploid human embryos is related to poor implantation potential and may be indicative of reduced metabolic fuel during oocyte maturation.

In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.

We have set out from here for the sublime. I have no doubt we shall arrive on time. 'Prospects' by Anthony Hecht.

The rise of the Internet Age has brought significant change to third-party reproduction. The implications of the freer informational exchange between third-party participants are examined. Recommendations are made regarding strategies fertility programs can use to navigate this new landscape.

Third-party reproduction is rapidly increasing. It involves a number of complex decisions that are better negotiated with guidance from a mental health professional.

The well-being of donor-conceived children is reviewed, disclosure trends are discussed, and child-related consequences of older parents using donor conception are considered with the goal of promoting the welfare of the child.

Mandatory counseling of gamete recipients is fraught with ethical questions for the mental health professional. Attention to issues of autonomy, confidentiality, and role clarity can diminish ethical conflicts.

Mental health professionals perform a psychoeducational role with intended parents, and evaluation with donors/surrogates; gatekeeping about ethics should be a team decision.