September 2015

All the papers from the September 2015 issue of Fertility and Sterility.

Diminished ovarian reserve in the United States assisted reproductive technology population Diagnostic trends among 181536 cycles from the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System

Diminished ovarian reserve (DOR) assignment increased 7% among all Society for Assisted Reproductive Technology Clinic Outcomes Reporting System cycles from 2004 to 2011, despite minimal increase in patient age at cycle start. The ability of DOR assignment to predict poor ovarian response worsened.

A sweet view of reproduction

In recent years, the advent of ‘omics’ has permitted large-scale molecular comparisons of cells, tissues, and secretions under different conditions. In reproductive medicine, ovarian and breast cancer, endometriosis, infertility, and failed implantation contribute significantly to the global burden of diseases. Much focus has been given to genomic markers used to generate molecular signatures of cells and organs, but more than 50% of expressed proteins are further modified by cotranscriptional and posttranscriptional events, which may not be reflected in altered gene expression profiles alone.