This instructional video demonstrates our recently described single-site robot-assisted laparoscopic myomectomy using the da Vinci Si platform with a multilumen port and wristed, semirigid instrumentation.
All the papers from the November 2015 issue of Fertility and Sterility.
Laparoscopic anatomy of the autonomic nerves of the pelvis and the concept of nerve sparing surgery by direct visualization of autonomic nerve bundles
Educational video demonstrating the anatomy of the autonomic nerves of he pelvis and the laparoscopic neuronavigation technique for nerve-sparing radical endometriosis surgery.
Wide excision of soft tissues adjacent to the ovary and fallopian tube does not impair the ovarian reserve in women undergoing prophylactic bilateral salpingectomy Results from a randomized controlled trial
Wide excision of the mesosalpinx does not impair ovarian reserve in women undergoing prophylactic salpingectomy. Moreover, wide salpingectomy is safe in terms of blood loss and postoperative recovery.
Laparoendoscopic single site myomectomy compared with conventional laparoscopic myomectomy A multicenter randomized controlled trial
Laparoendoscopic single-site surgery is a feasible and safe treatment option for myomectomy that offers surgical outcomes comparable to those with conventional laparoscopic myomectomy.
Long term follow up of patients with an isolated ovarian recurrence after conservative treatment of epithelial ovarian cancer: review of the results of a international multicenter study comprising 545 patients
Long-term survival of epithelial ovarian cancer patients with isolated ovarian recurrence after conservative treatment remains favorable; grade 3 tumors (compared with grades 1/2) have a higher rate of extraovarian recurrences.
Evaluation of the potential therapeutic effects of a double stranded RNA mimic complexed with polycations in an experimental mouse model of endometriosis
Polyethyleneimine prevented angiogenesis and promoted apoptosis in a mouse model of endometriosis, but prolonged treatments over time may be necessary to detect an effect of this compound on lesion size.
Clinical utility of magnetic resonance imaging and ultrasonography for diagnosis of polycystic ovary syndrome in adolescent girls
The current study suggests that MRI for determination of ovarian ultrastructure morphology in adolescent girls with PCOS may provide more information when compared with US.
Pregnancy associated plasma protein A in human ovarian follicles and its association with intrafollicular hormone levels
Pregnancy-associated plasma protein A in human follicular fluid from follicles with different diameters shows highly significant associations with sex-steroids and antimullerian hormone, suggesting important functions of insulin-like growth factors.
Comprehensive carrier genetic test using next generation deoxyribonucleic acid sequencing in infertile couples wishing to conceive through assisted reproductive technology
The comprehensive carrier genetic screening test developed here offers a powerful tool to detect alleles for hundreds of Mendelian diseases in patients.
Shallow whole genome sequencing is well suited for the detection of chromosomal aberrations in human blastocysts
A validation study on 47 embryonic trophectoderm samples demonstrates that shallow whole genome sequencing is a preferable alternative for array comparative genomic hybridization in detecting structural and numerical chromosomal rearrangements in preimplantation genetic diagnosis.
Novel mutations and polymorphisms in the CFTR gene associated with three subtypes of congenital absence of vas deferens
Detection of mutations in all coding regions of the CFTR gene has great significance for patients with congenital absence of vas deferens, particularly because the relevant studies have not been performed in China.
Novel FGFR1 mutations in Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism Evidence for the involvement of an alternatively spliced isoform
This study identified six new FGFR1 mutations responsible for IHH and provides evidence that an alternative form of the encoded protein (isoform IIIb) can also cause this disorder.
Live birth following in vitro maturation of oocytes retrieved from extracorporeal ovarian tissue aspiration and embryo cryopreservation for 5 years
Extracorporeal aspiration of immature oocytes from ovarian tissue, in vitro maturation, embryo cryopreservation, and a delayed frozen embryo transfer ultimately led to a live birth.
Liquid nitrogen vapor is comparable to liquid nitrogen for storage of cryopreserved human sperm Evidence from the characteristics of post thaw human sperm
Liquid nitrogen (LN2) vapor was comparable to LN2 with respect to post-thaw sperm characteristics, and LN2 vapor may substitute for LN2 for the long-term storage of human sperm.
Cryopreservation of testicular tissue before long term testicular cell culture does not alter in vitro cell dynamics
Cryopreservation of testicular tissue before culture does not influence the cell composition in longterm testicular cell cultures.
Using data from three infertility trials we identified race, ethnicity, body mass index, insurance coverage, history of smoking, and history of alcohol use as significant predictors of retention.
Urinary phthalate metabolite concentrations in relation to history of infertility and use of assisted reproductive technology
Among women with a history of infertility and planned pregnancies, concentrations of diethylhexyl phthalate (DEHP) metabolites and their molar sum (PDEHP) were significantly lower in women who conceived after assisted reproductive technology (ART) compared with those who conceived without ART.
Women initiating treatment with assisted reproduction technology (ART) have no greater short-term risk for developing cancer compared with the general population or other women treated with ART.
We describe pregnancies in a large group of patients with hypopituitarism, finding that GH replacement is not related to healthy live births, gestational age at delivery, and birth weight.
Nuclear magnetic resonance metabolomic profiling of urine provides a noninvasive alternative to the identification of biomarkers associated with endometriosis
A comparative analysis of urine metabolomic profiles, based on 1H-NMR spectroscopy, of endometriosis patients and healthy women facilitates the noninvasive identification of metabolites discriminating both groups.
Association between previously unknown connective tissue disease and subclinical hypothyroidism diagnosed during first trimester of pregnancy
Connective tissue diseases are associated to autoimmune thyroid disorders in pregnancy. Thyroid autoimmunity and antinuclear antibodies could have a detrimental effect on pregnancy outcomes.
Elevated serum interleukin 1β levels and interleukin 1β to interleukin 1 receptor antagonist ratio 1 week after embryo transfer are associated with ectopic pregnancy
Elevated early luteal phase interleukin-1b serum levels and interleukin-1b-to-interleukin-1 receptor antagonist ratio were associated with ectopic pregnancy after an in vitro fertilization cycle.
Low dose progestin releasing contraceptives are associated with a higher pain threshold in healthy women
Women who used progestin-containing contraceptives had higher pain thresholds than healthy controls.
Influence of different oocyte insemination techniques on early and late morphokinetic parameters Retrospective analysis of 500 time lapse monitored blastocysts
In vitro fertilization–fertilized embryos developed with a 1.5-hour delay, which disappeared after standardization to pronuclear fading, thus permitting the joint analysis of standard IVF- and ICSI-fertilized embryo cohorts.
Can calcium ionophore use in patients with diminished ovarian reserve increase fertilization and pregnancy rates A randomized controlled study
Routine usage of Calcium ionophore solution to increase fertilization rate, pregnancy rate, and ongoing pregnancy rate is not appropriate for patients who have diminished ovarian reserve.
BRCA mutation carriers are often claimed to harbor diminished reproductive performance. An in vitro fertilization database reveals intact ovarian reserve in both healthy and cancer-affected BRCA mutation carriers.
Dynamic antimullerian hormone levels during controlled ovarian hyperstimulation predict in vitro fertilization response and pregnancy outcomes
The rate of antimullerian hormone decline during controlled ovarian hyperstimulation is associated with ovarian reserve, in vitro fertilization response, and clinical pregnancy, particularly in women older than 35 years of age.
Gonadotropin dose is negatively correlated with live birth rate Analysis of more than 650000 assisted reproductive technology cycles
Live birth rate decreased with increasing follicle stimulating hormone dose, regardless of number of oocytes retrieved.
Outcomes using embryos cryopreserved at the blastocyst stage or bipronuclear stage followed by thaw and culture to the blastocyst stage did not differ significantly.
Meiotic errors involving chromosome 16 of paternal origin seem to have an equally important influence on to the overall fetal aneuploidy rate compared with maternal chromosome 16 disomy.
Reflections on “Cryopreservation of testicular tissue prior to long-term testicular cell culture does not alter in vitro cell dynamics” by Baert et al.
The inherent difficulties of meta analysis for surgical techniques in male infertility An argument for standardizing reporting and outcomes
Reflections on “A Comparison of Microdissection Testicular Sperm Extraction, Conventional Testicular Sperm Extraction, and Testicular Sperm Aspiration for Nonobstructive Azoospermia: A Systematic Review and Meta-analysis” by Bernie et al.
Disparities in access to effective treatment for infertility in the United States An Ethics Committee opinion
This opinion examines the factors that contribute to disparities in access to fertility care in the United States and proposes actions to address them.
Comparison of microdissection testicular sperm extraction conventional testicular sperm extraction and testicular sperm aspiration for nonobstructive azoospermia A systematic review and meta analysis
Sperm retrieval was higher for microdissection compared with conventional testicular sperm extraction, and was also higher for conventional testicular sperm extraction compared with testicular sperm aspiration.
Ovarian cortex transplantation Time to move on from experimental studies to open clinical application
In the context of treating cancer, fertility preservation (FP) in young women is a major challenge. Many questions remain because controversial issues still exist (1). Unfortunately, only a small number of patients at risk of premature ovarian failure are referred to FP specialists to discuss different options (1). As reproduction specialists, we consider it vital to provide oncologists, hematologists, and all healthcare providers with accurate information, based on firm evidence, on fertility-sparing treatments, which could potentially have devastating consequences on their future quality of life.
This article provides a summary of the biopsychosocial model and the assessment and treatment of psychologically based male sexual dysfunction as manifested in cases of infertility.
Delayed orgasm and anorgasmia are associated with significant sexual dissatisfaction. There are many potential etiologies; unfortunately, there are no excellent pharmacotherapies. Treatment revolves around addressing potential causative factors and psychotherapy.
Treatment for aspermia, or a dry ejaculate, must be tailored to the individual patient and include consideration of ease of administration, degree of invasiveness, and anticipated success.