A novel, 3-dimensional, real-time, sperm-imaging technique, in which live spermatozoa are kept in a fluid environment, avoids staining and air-drying artifacts, and still allows for sperm to be used clinically.
Human CD133 bone marrow derived stem cells promote endometrial proliferation in a murine model of Asherman syndrome
To study the involvement of labelled CD133 bone marrow-derived stem cells (BMDSCs) in an animal model of Asherman syndrome. BMDSCs might improve the uterine tissue as a valuable source for endometrial restoration.
Cross sectional study of factors influencing sex hormone binding globulin concentrations in normally cycling premenopausal women
In normally cycling premenopausal women, SHBG concentrations, independently from other parameters, are negatively associated with bioavailable T and positively associated with adiponectin.
Antimüllerian hormone levels and numbers and sizes of antral follicles in regularly menstruating women of reproductive age referenced to true ovulation day
Antimullerian hormone (AMH) concentrations vary across ovulatory menstrual cycles with a periovulatory base and lower luteal phase levels. The number of antral follicles may be estimated from the level of AMH.
Mid pregnancy perinatal and neonatal reproductive endocrinology A prospective cohort study in twins and singleton control subjects
Twin children are not overexposed to sex steroids at the time of birth, despite higher concentrations in their mothers. Opposite-sex twin girls do not show androgenic influence from their male co-twins. Boys of an opposite-sex twin have lower LH concentrations compared with same-sex dizygotic twin boys.
Chlamydia trachomatis immunoglobulin G3 seropositivity is a predictor of reproductive outcomes in infertile women with patent fallopian tubes
Even in the presence of tubal patency, Chlamydia trachomatis immunoglobulin G3 seropositivity is associated with a lower likelihood of pregnancy and an increased risk of ectopic pregnancy.
Sexual activity modulates shifts in TH1 TH2 cytokine profile across the menstrual cycle An observational study
Sexually active women had significantly higher luteal- phase P-E2 ratios and TH2-like cytokine profiles (interferon-g < interleukin-4) than sexually abstinent women.
In patients with normal ovarian reserve, comprehensive chromosome screening increases clinical and sustained implantation rates, thus improving embryo selection.
New methods to improve the safety assessment of cryopreserved ovarian tissue for fertility preservation in breast cancer patients
GCDFP15, MGB1, and SBEM were the most sensitive molecules to create a diagnostic panel for breast cancer malignant cell contamination, making cryopreservation of ovarian cortex–orthotransplantation safe for fertility preservation.
Neither pregnancy planning nor timing showed a significant association with preterm or small for gestational age births in this large prospective cohort controlling for confounders.
Ultramicro trauma in the endometrial myometrial junctional zone and pale cell migration in adenomyosis
Adenomyosis uteri showed a unique nonhematopoietic cell population migrating from the basal endometrial glands into the stroma, and microtraumata at the junctional zone.
Inflammatory processes may contribute to pregnancy loss, possibly through their role in implantation.
Noninferiority randomized controlled trial comparing embryo development using media developed for sequential or undisturbed culture in a time lapse setup
In this randomized sibling study we found no differences in blastocyst development between sequential and single-step media.
Effect of treatment of a previous ectopic pregnancy on in vitro fertilization intracytoplasmic sperm injection outcomes A retrospective cohort study
This retrospective cohort study demonstrates that a history of ectopic pregnancy carries a higher risk of recurrent ectopic pregnancy after in vitro fertilization– intracytoplasmic sperm injection.
There is an association between ectopic pregnancy and the culture medium.
Live birth rates in very poor prognosis patients who are defined as poor responders under the Bologna criteria with nonelective single embryo two embryo and three or more embryo transfers
By presenting age-specific live birth rates in a population of very poor prognosis patients, we demonstrate that such patients even in their mid-40s can still achieve acceptable live-birth rates.
Six years experience in ovum donation using vitrified oocytes Report of cumulative outcomes impact of storage time and development of a predictive model for oocyte survival rate
Oocyte banking is clinically efficient. Estimation of the likelihood of having a child is provided. There is no way of estimating donors’ oocytes survival when considering baseline characteristics, storage time, or controlled ovarian stimulation parameters.
450 IU versus 600 IU gonadotropin for controlled ovarian stimulation in poor responders A randomized controlled trial
Our randomized controlled trial showed poor ovarian response, a microdose GnRH-a flare-up protocol with a daily dose of 600 IU gonadotropin does not significantly increase the number of mature (MII) oocytes compared with 450 IU/d.
Difference in birth weight of consecutive sibling singletons is not found in oocyte donation when comparing fresh versus frozen embryo replacements
With the use of oocyte donation-originated siblings, and controlling for potential laboratory and clinical confounders, similar birth weight and duration of gestation were observed with both fresh and frozen embryos.