Should progesterone on the human chorionic gonadotropin day still be measured?

In 1,901 IVF cycles, a cut-off value of P on the hCG day differentiating good- from poor-prognosis cycles was not identified; therefore, clinical decisions should be based on other individual circumstances.

0
0

Authors

Francisca Martinez, Ph.D., Ignacio Rodriguez, B.Sc., Marta Devesa, M.D., Rosario Buxaderas, M.D., Maria José Gómez, B.Sc., Buenaventura Coroleu, Ph.D.

Volume 105, Issue 1, Pages 86-92

Abstract

Objective:

To evaluate in our setting whether there is currently a level of P on the hCG day (P-hCG) predictive of no pregnancy.

Design:

Observational study of prospectively collected data of the P-hCG levels of stimulated IVF cycles.

Setting:

In vitro fertilization unit.

Patient(s):

All cycles of IVF/intracytoplasmic sperm injection with fresh embryo transfer performed between January 2009 and March 2014.

Intervention(s):

None.

Main Outcome Measure(s):

Pregnancy rate.

Result(s):

Clinical pregnancy rate per ET was 38.7% and live birth rate was 29.1%. The P-hCG concentration was positively correlated to E2 on the hCG day, and the number of oocytes was negatively correlated to age. Progesterone on hCG day was higher among agonist- compared with antagonist-treated patients (1.13 ± 0.69 ng/mL vs. 0.97 ± 0.50 ng/mL) and among recombinant FSH compared with recombinant FSH + hMG stimulation (1.11 ± 0.58 ng/mL vs. 0.94 ± 0.50 ng/mL). Pregnancy rate was positively associated with the number of oocytes. There was no correlation between P-hCG value and pregnancy rate, overall or according to the type of treatment.

Conclusion(s):

In our setting there is no P-hCG value differentiating a good from a poor cycle success rate.

Clinical Trial Registration Number:

NCT02323347.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)01925-1/fulltext

Medium untitled 1

Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

No comments yet.