Evidence of a genetic link between endometriosis and ovarian cancer

There is a clear genetic link between endometriosis and risk of ovarian cancer, especially for the highgrade serous and clear cell histotypes.

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Authors

Alice W. Lee, M.P.H., Claire Templeman, M.D., Douglas A. Stram, B.S., Jonathan Beesley, Ph.D., Jonathan Tyrer, Ph.D., Andrew Berchuck, M.D., Paul P. Pharoah, Ph.D., Georgia Chenevix-Trench, Ph.D., Celeste Leigh Pearce, Ph.D. on behalf of the Ovarian Cancer Association Consortium

Volume 105, Issue 1, Pages 35-43

Abstract

Objective:

To evaluate whether endometriosis-associated genetic variation affects risk of ovarian cancer.

Design:

Pooled genetic analysis.

Setting:

University hospital.

Patient(s):

Genetic data from 46,176 participants (15,361 ovarian cancer cases and 30,815 controls) from 41 ovarian cancer studies.

Intervention(s):

None.

Main Outcome Measure(s):

Endometriosis-associated genetic variation and ovarian cancer.

Result(s):

There was significant evidence of an association between endometriosis-related genetic variation and ovarian cancer risk, especially for the high-grade serous and clear cell histotypes. Overall we observed 15 significant burden statistics, which was three times more than expected.

Conclusion(s):

By focusing on candidate regions from a phenotype associated with ovarian cancer, we have shown a clear genetic link between endometriosis and ovarian cancer that warrants further follow-up. The functional significance of the identified regions and SNPs is presently uncertain, though future fine mapping and histotype-specific functional analyses may shed light on the etiologies of both gynecologic conditions.

Read the full text at: http://www.fertstert.org/article/S0015-0282(15)01940-8/fulltext


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Fertility and Sterility

Editorial Office, American Society for Reproductive Medicine

Fertility and Sterility® is an international journal for obstetricians, gynecologists, reproductive endocrinologists, urologists, basic scientists and others who treat and investigate problems of infertility and human reproductive disorders. The journal publishes juried original scientific articles in clinical and laboratory research relevant to reproductive endocrinology, urology, andrology, physiology, immunology, genetics, contraception, and menopause. Fertility and Sterility® encourages and supports meaningful basic and clinical research, and facilitates and promotes excellence in professional education, in the field of reproductive medicine.

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