Is preimplantation genetic testing for aneuploidy (PGT-A) an essential tool for embryo selection or costly 'add-on' of no clinical benefit?
Volume 110, Issue 3, Pages 351–352
Zev Rosenwaks, M.D., Alan H. Handyside, Ph.D.
Chromosome aneuploidy is common in human gametes and preimplantation embryos and is a major cause of in vitro fertilization (IVF) failure, miscarriage, and still births, with an incidence at birth of less than 0.3%. Most aneuploidies originate in the oocyte through errors in maternal meiosis and these increase exponentially in women in their late 30s and early 40s. This is associated with a sharp increase in the incidence of miscarriage and a corresponding decline in live birth rates in these women following IVF.