The pros and cons of preimplantation genetic testing for aneuploidy (PGT-A): clinical and laboratory perspectives
Volume 110, Issue 3, Pages 353–361
Zev Rosenwaks, M.D., Alan H. Handyside, Ph.D., Francesco Fiorentino, Ph.D., Norbert Gleicher, M.D., Richard J. Paulson, M.D., Glenn L. Schattman, M.D., Richard T. Scott Jr., M.D., Michael C. Summers, M.D., Ph.D., Nathan R. Treff, Ph.D., Kangpu Xu, Ph.D.
To contribute to a balanced debate, we invited leading proponents and opponents of preimplantation genetic testing for aneuploidy (PGT-A) to briefly summarize their arguments. Four contributors debate the pros and cons from a clinical perspective, two consider technical aspects related to the validation and accuracy of current methodologies, and finally two consider the implications of chromosomal mosaicism, which has recently been identified using next-generation sequencing–based chromosome copy number analysis.