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Long-term safety of in vitro maturation was evaluated in a matched setting with in vitro fertilization. This is the largest study showing that no significant increased risk associated with in vitro maturation has been identified after a mean follow-up of 7.5 years.
The prevalence of embryonic aneuploidy is the same in natural cycles and those employing superovulation. Prior concerns that exogenous gonadotropins increase embryonic aneuploidy are unsupported by this data.